Gene Information

Name : kdsB (NTHI0068)
Accession : YP_247721.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 60867 - 61631 bp
Length : 765 bp
Strand : -
Note : CMP-KDO synthetase; CMP-2-keto-3-deoxyoctulosonic acid synthetase; CKS; CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGTCATTTACCGTTATTATCCCCGCTCGTTTTGCATCAAGTCGTTTACCTGGAAAACCGCTTGCCGATATTGCAGGTAA
GCCAATGATTCAACATGTATTTGAGAAAGCGCTGCAGTCTGGGGCGAACCGAGTGATTATTGCCACCGATAATGAAAATG
TGGCTGATGTTGCCAAAAATTTTGGCGCGGAAGTGTGCATGACTTCGGTTAATCATAATTCTGGTACAGAACGTTTAGCG
GAAGTTGTAGAAAAATTAGCGATTCCTGACAATGAAATCATTGTCAATATTCAAGGCGATGAGCCTTTGATTCCTCCCGT
TATCGTGCGACAAGTGGCAGATAATTTAGCAAAATTTAATGTCAATATGGCAAGTCTTGCGGTAAAAATTCATGATGCTG
AGGAATTATTCAATCCAAATGCAGTGAAAGTTTTGACGGATAAAGACGGCTATGTGCTATATTTTTCCCGTTCGGTTATT
CCTTACGATCGTGATCAGTTTATGAATTTACAGGATGTTCAGAAAGTACAGCTTGCGGACGCTTACTTACGTCATATTGG
CATTTACGCATATCGTGCGGGGTTCATAAAACAATATGTGCAATGGGCTCCGACTCAACTTGAAAATCTAGAAAAACTTG
AGCAGCTTCGTGTGTTATATAACGGCGAACGCATTCACGTAGAGCTTGCGAAAGAAGTGCCTGCAGTGGGGGTGGATACT
GCTGAAGATTTGGAAAAAGTGCGGGCAATTTTAGCGGCGAATTAA

Protein sequence :
MSFTVIIPARFASSRLPGKPLADIAGKPMIQHVFEKALQSGANRVIIATDNENVADVAKNFGAEVCMTSVNHNSGTERLA
EVVEKLAIPDNEIIVNIQGDEPLIPPVIVRQVADNLAKFNVNMASLAVKIHDAEELFNPNAVKVLTDKDGYVLYFSRSVI
PYDRDQFMNLQDVQKVQLADAYLRHIGIYAYRAGFIKQYVQWAPTQLENLEKLEQLRVLYNGERIHVELAKEVPAVGVDT
AEDLEKVRAILAAN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 1e-39 44
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 2e-39 44
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 8e-40 44