Gene Information

Name : nanK (NTHI0230)
Accession : YP_247864.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 221724 - 222626 bp
Length : 903 bp
Strand : -
Note : ManNAc kinase; catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGCGTTGTTTAGCACTAGATATTGGTGGGACAAAAATTGCAGCGGCGATTGTAAAAAATGGCGAAATTGAGCAACGTCA
GCAAATTCATACACCACGTGAAAATGTCGTGGAGGGAATGCACCAAGCGTTAGGCAAATTGCTTGCTGATTATGAAGGGC
AGTTTGATTATGTAGCGGTAGCATCTACGGGGATTATCAATAATGGTATTTTAAGTGCATTAAATCCGAAAAACTTAGGT
GGCTTGGCGGAATTTCCACTTAAAGCGAGTATTGCAAAACATACGGATAAACCGATTGGTTTATTAAATGATGCACAAGC
TGCGACTTATGCGGAATATCAATTGCAAAATTTTGAACAGGTATCAAATTTTGTTTTTATTACCGTTTCAACAGGAGTTG
GCGGAGGGATTGTGCTGAACCAAATTTTGCAGACAGGTTCTCGTGGTATTGCAGGGCATATTGGTCATACATTAGCTGAT
CCAAATGGTGCGATCTGTGGTTGTGGTCGTCGAGGTTGTGTCGAAGCGATTGCTTCAGGGCGAGCAATTGAAGCAGTTTC
TTCCCAATGGGAAGATCCGTGCGATCCAAAAGAAGTGTTTGAGCGTTTTAGAAAAAATGATGAAAAAGCGACCGCACTTG
TCGAGCGTTCTGCGAAAGCCATTGCTAATTTAATTGCTGATTTAGTGATTAGTTTAGATATTCAAAAAATCGCGATTGGT
GGCAGTGTGGGATTAGCTGAGGGATATTTATCTTTGGTTGAAAAATATTTACAAGATTTTCCTTCGATATATTGTTGTGA
AATTGAAACCGCTAAATTTGGACAAGATGCAGGTTTAATTGGCGCAGCTTATTGGGTAAAAGATGTTTTACTGGATAAGC
CTGAAGGAACAATTTATGGCTAA

Protein sequence : 
MRCLALDIGGTKIAAAIVKNGEIEQRQQIHTPRENVVEGMHQALGKLLADYEGQFDYVAVASTGIINNGILSALNPKNLG
GLAEFPLKASIAKHTDKPIGLLNDAQAATYAEYQLQNFEQVSNFVFITVSTGVGGGIVLNQILQTGSRGIAGHIGHTLAD
PNGAICGCGRRGCVEAIASGRAIEAVSSQWEDPCDPKEVFERFRKNDEKATALVERSAKAIANLIADLVISLDIQKIAIG
GSVGLAEGYLSLVEKYLQDFPSIYCCEIETAKFGQDAGLIGAAYWVKDVLLDKPEGTIYG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 3e-38 49
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 2e-33 44
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 2e-33 44
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 1e-32 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanK YP_247864.1 N-acetylmannosamine kinase VFG1115 Protein 8e-34 44