Gene Information

Name : hsdM3 (NTHI1838)
Accession : YP_249266.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Unknown
Product : type I restriction enzyme HindVIIP M protein
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 1690210 - 1691880 bp
Length : 1671 bp
Strand : +
Note : M.HindVIIP; Similar to: HI1287, T1MH_HAEIN

DNA sequence :
ATGCAAGCGAGACGAGACACCAAGATTGTCGATGAAAATCACACATTACAACAAGCATTTTTAAACGATTTAGACGAAAA
ACTTTGGTCATCTGCGGATAAACTCCGCCAACAACTTGATGCCGCCAACTATAAACATATCGTTCTTGGTCTCATCTTCT
TAAAATACATTTCTGATAATTTCACTCATCAACAGGAAAAAATTCAGGCAGAACTTTCTGATGCTGAAAATCCCCTCTAT
CTTGACCGCACTTTTTTTGATACTGAAGAAGAATATCAAGAAGCTTTAACCGCAGAACTAGAAAACCGTGATTATTACAC
CGCGGATAACGTATTTTGGGTGCCCGCTTCTGCACGTTGGCAAGCCTTACAAGAAGTCTCTATTCTCAACACTGGTGCAG
AATTACCTTGGGGTGGTAAATTCTCAGGCGTGGCAAAACTGATTGATGATGCCTTTGATGCCATTGAAAAAGACAACGAA
AAACTCAAAGGCGTCCTCCAACGCATCAGCGGCTATGCCGTAAACGAAGACACCCTGCGCGGGCTGATTATCCTCTTCTC
CGATACTAACTTTACCCGCCCGACTTACAACGGCGAGCCCGTACATTTAGGTGCAAAAGACATACTCGGCCATGTTTACG
AATACTTCCTCGGTCGCTTTGCCCAAGCCGAAGGCAAACGCGGCGGGCAATATTTCACGCCGAAATCCATCGTTTCCCTG
ATTGTCGAAATGCTCGAGCCATACTCCGGCCGCGTGTATGACCCAGCTATGGGCAGTGGCGGCTTTTTCGTGCAAACCGA
ACGCTTTATTACCGCCCATCAAGGCAACATCAACAACGTGTCCATCTACGGGCAAGAATTCAACCCCACCACATGGAAGC
TCGCCGCCATGAATATGGCGATTCGCGGCATTGATTACGACTTCGGCAAACACAACGCCGACAGTTTCACCCAGCCGCAA
CACATCGACAAAAAGATGGATTTCATTATGGCAAACCCGCCATTCAATATCAGCGATTGGTGGAGCGAATCCCTTGCCGA
TGATCCACGTTGGGCATACGGCACACCACCCAAAGGCAACGCCAACTTCGCTTGGCTGCAACACATGATTTACCACCTCT
CACCCAACGGCAAAATGGCATTATTGCTTGCCAACGGCTCCATGAGCAGCCAAACCAACAACGAAGGCGAAATCCGCAAA
GCCATCATCAATGCCGACTTGGTCGAATGTATGGTTGCCCTGCCCGGTCAGCTCTTCACCAACACCCAAATCCCTGCCTG
TATTTGGTTTTTAAACCGCAACAAAAAACGCAAAGGCGAAGTGTTGTTTATCGATGCCCGCCAAATCGGCTATATGAAAG
ACCGCGTATTGCGTGATTTCACCGCTGACGACATCGCCAAAATTGCCGACACCCTCCACACTTGGCAAAAATCAGACGGC
TATGAAGACCAAGCCGCTTTCTGTAAATCCGCTACGTTAGAAGAGATTAAAGACAACGACTTCGTCCTCACACCAGGGCG
CTATGTCGGCACCGCAGAACAAGAAGATGACGGCGTGCCATTTGCAGAAAAAATGCAAAATCTGACCGCTCTTTTGAAGG
AGCAATTTGCGAAAAGTGCGGAATTGGAAGCAGAAATTAAGAAGAATTTAGGGGGATTGGGGTATGAGTAA

Protein sequence :
MQARRDTKIVDENHTLQQAFLNDLDEKLWSSADKLRQQLDAANYKHIVLGLIFLKYISDNFTHQQEKIQAELSDAENPLY
LDRTFFDTEEEYQEALTAELENRDYYTADNVFWVPASARWQALQEVSILNTGAELPWGGKFSGVAKLIDDAFDAIEKDNE
KLKGVLQRISGYAVNEDTLRGLIILFSDTNFTRPTYNGEPVHLGAKDILGHVYEYFLGRFAQAEGKRGGQYFTPKSIVSL
IVEMLEPYSGRVYDPAMGSGGFFVQTERFITAHQGNINNVSIYGQEFNPTTWKLAAMNMAIRGIDYDFGKHNADSFTQPQ
HIDKKMDFIMANPPFNISDWWSESLADDPRWAYGTPPKGNANFAWLQHMIYHLSPNGKMALLLANGSMSSQTNNEGEIRK
AIINADLVECMVALPGQLFTNTQIPACIWFLNRNKKRKGEVLFIDARQIGYMKDRVLRDFTADDIAKIADTLHTWQKSDG
YEDQAAFCKSATLEEIKDNDFVLTPGRYVGTAEQEDDGVPFAEKMQNLTALLKEQFAKSAELEAEIKKNLGGLGYE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 1e-176 64
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 2e-127 50
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 2e-127 50
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 5e-125 49