Gene Information

Name : alr (NTHI1476)
Accession : YP_248951.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Unknown
Product : alanine racemase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0787
EC number : 5.1.1.1
Position : 1403881 - 1404963 bp
Length : 1083 bp
Strand : -
Note : converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer

DNA sequence :
ATGAACGTAAAACCGGCGACAGCGAAAATCAGTTCGCACGCCTTAAAACAAAATTTAGAAATAATTAAACAAAAAGCACC
AAATAGCAAAATTATTGCTGTGGTTAAAGCAAACGCTTATGGTCACGGCGTTGTGTTTGTTGCATCAACTTTAGAACAAA
ATGTCGATTGCTTTGGCGTGGCTCGTTTAGAAGAGGCTTTAGCATTACGCTCCAACGGCATCACTAAACCGATTTTATTA
CTTGAAGGCTTTTTTAATGAACAAGATTTGCCTATTCTAGCCGTTAATAATATTGAAACCGTGGTACACAATCACGAACA
GCTTGAGGCTTTAAAACGTTCAAATTTACCAAGTCCAATTAAGGTTTGGTTAAAAATAGATACGGGAATGCACCGTTTAG
GCGTTGCTCTTGATGAAGTGGATTATTTTTATCAAGAACTGAAAAAACTCCCTCAAATTCAACCGCACTTAGGCTTTGTC
AGCCATTTCAGCCGAGCCGATGAACTAGAATCAGATTACACCCAACTTCAAATCAATCGTTTTTTATCCGCCACAAAAGA
TAAACAAGGTGAACGCACTATCGCAGCTTCTGGCGGCATTCTTTTCTGGCCAAAATCTCACTTAGAATGTATTCGCCCAG
GCATTATTATGTACGGCATTTCTCCAACTGATACTATTGGCAAAGAGTTTGGCTTAACGCCAGTGATGAATTTAACCTCG
TCATTAATTGCCGTTCGCCATCATAAACAAGGCGATCCTGTAGGTTACGGCGGTATTTGGACAAGTCCACGAGATACCAA
AATTGGCGTGGTCGCAATGGGTTATGGCGATGGTTATCCGCGCGATGTGCCAGAAGGTACGCCTGTTTATTTAAATGGCC
GTCTCGTACCAATTGTTGGACGTGTGTCAATGGATATGCTCACTGTTGATTTAGGCGCAGATAGCCAAGATTTGGTAGGC
GATGAAGTAATTTTATGGGGCAAGGAATTACCTATTGAAACCGTAGCTAAATTCACAGGCATTTTAAGCTACGAGCTAAT
TACAAAATTAACACCTCGTGTTATAACTGAATACGTTGATTAA

Protein sequence :
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGVARLEEALALRSNGITKPILL
LEGFFNEQDLPILAVNNIETVVHNHEQLEALKRSNLPSPIKVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFV
SHFSRADELESDYTQLQINRFLSATKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVGRVSMDMLTVDLGADSQDLVG
DEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dadX AAC61705.1 alanine racemase Not tested PAI I CFT073 Protein 2e-59 42