Gene Information

Name : smpB (NTHI1153)
Accession : YP_248678.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 1095234 - 1095719 bp
Length : 486 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGACAAAGAAAAAAGTAAAACCCAATTCAAATACTATCGCACTGAATAAACGTGCAAGACACGATTATTTTATTGAAGA
TGAAATTGAAGCAGGTCTTGAATTACAAGGCTGGGAAGTCAAATCTATGCGCGCAGGCAAGGCAAATATTAGTGATAGTT
ATGTTATTTTTAAAAATGGCGAAGCCTTTTTATTCGGCGCAAGCATTCAGCCATTAAATGTTGCATCAACGCATATTGTT
TGTGATCCAACTCGCACTCGTAAGTTATTGTTAAATAAACGCGAATTAGCATCCCTATTTGGCAAAGCAAACCGAGACGG
TTTTACCATAGTTGCACTTTCTCTTTACTGGAAAAGTGCGTGGGCAAAAGTCAAAATCGGTTTAGCCAAAGGTAAAAAAC
AACAGGATAAACGTGATGATATTAAAGAACGTGAATGGAAAGTAACAAAAGATCGCATTATGAAAAATGCACATCGAAGA
TCTTAA

Protein sequence :
MTKKKVKPNSNTIALNKRARHDYFIEDEIEAGLELQGWEVKSMRAGKANISDSYVIFKNGEAFLFGASIQPLNVASTHIV
CDPTRTRKLLLNKRELASLFGKANRDGFTIVALSLYWKSAWAKVKIGLAKGKKQQDKRDDIKEREWKVTKDRIMKNAHRR
S

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 4e-50 67
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 6e-24 49
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 2e-18 42