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Name : topB2 (NTHI0112) Accession : YP_247759.1 Strain : Haemophilus influenzae 86-028NP Genome accession: NC_007146 Putative virulence/resistance : Unknown Product : DNA topoisomerase III Function : - COG functional category : L : Replication, recombination and repair COG ID : COG0550 EC number : 5.99.1.2 Position : 101746 - 103806 bp Length : 2061 bp Strand : + Note : decatenates replicating daughter chromosomes DNA sequence : ATGAGAGAAAACATCATGAAATTATTTTTATGTGAAAAACCATCACAAGGCAATGATATTGCAAAAGTATTAGGTGCGAC AAAGCGTGGTGAGGGTTGTTTATCAACACCTGACGGTCAGCTTACAGTTACCTGGGGAATTGGTCATCTAGTAGAGCAAT TTAATCCTGAAGAATATGATCCTGCCTTTAAAAAGTGGGCATTTGAGACCTTGCCAATTATCCCGGGTAAATGGGGGCTT TCACCTAAAAAAGAAACAAAAAAACAGTTCAATGTCGTCATGAAACTTATCAAACAAGCTAAACTTGTTGTCATTGCAAC CGATATTGATAGAGAGGGCGAAACTATAGCAAGAGAATTGCTGGATTTGGCAGGATTTCGAGGGCAAATAAAACGCCTTT GGTTGTCTGCACTAGATGATACCAGTATTCGCAAAGCCTTGGGCGCACTTAAAAATAATGAGGAGACACTACCTCTTTAC TATGCGGGACTTGCACGTAGTCGAGCTGATTGGCTTATTGGTATGAATTTCTCTCGTCTCTATACCTTATTAGCGCAACA ACAAGGGTATCAAGGGAAACCTTTAAGTGTTGGTCGGGTACAAACTCCAACATTAAGCTTGGTTGTTAATCGTGACCGTG AGATAAAAAACTTCATTCCTAAGCAACATTTTGCTTTGCAAGTAATGCTTTCTGATGGAAATCAGCATTTTGCTACGCAA TATGTTATTCCGGAGCAATATTGTGATCCTGATGGACTTTGTTTGTCTGCCCAAGTTATACAAGCAGCAAATCAGCAAAT TCGCCAATTTGGCCAAGCGAAAGTGGAATCAGTTGAAACTAAACGTGAAAGACAAAATGCCCCACTTTGCTTTGCATTAA GTGACTTACAATCAGAAGCTAACCGCCTTTATGGACTGGGTGCGCAAAGAGTATTGGATATAGCTCAATCACTTTATGAG ACTCACAAAGCGACAACCTATCCTAGAACAGATTGTGGTTATTTACCGGAGTCTCAGTTTGCAGAAGCGCCTCAAATTAT CCAATGTTTGTTGCAATCCGATAATCGATTACACCCCCTTGCAGGTATGTTAAACCTTAATCAAAAATCACGAGTTTGGA ATGATAAAAAAATTACTGCTCACCATGGCATTATTCCGACTATGATTAAAGCTGATATTAGCAAAATGTCTGATGAAGAA TTAAAGCTCTATGATCTCATACGTCGTCGTTATTTAGCTCAATTCTTACCTGTTTCTGAAACAGATAAGACACAAATTAT TTTGAAGTGCGGTCAACATATATTAAGTGCACGTGGGAATGTGCTTATTGCTCCAGGTTGGAAAATTCTATTTGGCAAAT CACTTGATGAAGATGATGACGCACCTCAAGCCTTGCCGACGTTAAAGCAAGGACAAATCTGTCAGATTTCTGATTCAGAA ATAAAAACCTTACAAACATCACCACCTAATCACTTCACGGAAGGTACATTGCTCACCGCAATGAAAAATGCAGCTCGCTT TGTAACTGATGAGCGTTTAAAACAACGCTTACGAGAAACTGAAGGGCTTGGAACAGAAGCTACTCGGGCGGGAACGATTC AAGGTTTGATTGATAAAGGTTTCTTGAAAAAGAAAGGTAAATCACTATTAGCGACAGATGAAGCAATGACGCTAATTGAT AATTTACCTCAGATGTTAAAAGATCCGGGTTTAACCGCACTTTGGGAGCAAGCGCTCAATCAAATTGCTGAAAGAACGCT TTCGCTAGAAGTGTTTATGCAAAAACAAGAAGTCTTTGTGCGGCATTTGATGGCTGATTGCCTTAAAAAGGGAATGAGTT TGGGGAATATTGAAATTCGTAAATGCCCTAAGTGCGGTGCACCAATGATTAAAAGAAATGGTAAAAATGGGGCTTTTTTT GGGTGTTCTGCTTATCCAAATTGCCAACATATTGAAAATATTGATAGCAAGAAGAATACTAAAAGTACAAAAAATTTAAA GAAAAAGTCGAGTAAAAGTGTGAGTGAGCAAATTTCATCTTTACGAAGCTTATTGAACTAG Protein sequence : MRENIMKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGL SPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLY YAGLARSRADWLIGMNFSRLYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQ YVIPEQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYE THKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEE LKLYDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSE IKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLID NLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFF GCSAYPNCQHIENIDSKKNTKSTKNLKKKSSKSVSEQISSLRSLLN |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| topB1 | YP_005176228.1 | DNA topoisomerase III | Not tested | ICEPmu1 | Protein | 0.0 | 68 |
| pph56 | CAI36097.1 | Topoisomerase IA | Not tested | PPHGI-1 | Protein | 2e-158 | 52 |
| topB | AAN62194.1 | putative DNA topoisomerase III | Not tested | PAGI-2(C) | Protein | 2e-162 | 52 |
| topB | AAF14809.1 | topoisomerase B | Not tested | SPI-7 | Protein | 6e-154 | 51 |
| topB | NP_458624.1 | topoisomerase B | Not tested | SPI-7 | Protein | 8e-154 | 51 |
| topB | NP_807836.1 | DNA topoisomerase III | Not tested | SPI-7 | Protein | 8e-154 | 51 |
| topB | AAN62317.1 | putative DNA topoisomerase III | Not tested | PAGI-3(SG) | Protein | 2e-152 | 50 |
| PMI2630 | YP_002152332.1 | DNA topoisomerase III | Not tested | Not named | Protein | 1e-143 | 47 |
