Gene Information

Name : topB2 (NTHI0112)
Accession : YP_247759.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 101746 - 103806 bp
Length : 2061 bp
Strand : +
Note : decatenates replicating daughter chromosomes

DNA sequence :
ATGAGAGAAAACATCATGAAATTATTTTTATGTGAAAAACCATCACAAGGCAATGATATTGCAAAAGTATTAGGTGCGAC
AAAGCGTGGTGAGGGTTGTTTATCAACACCTGACGGTCAGCTTACAGTTACCTGGGGAATTGGTCATCTAGTAGAGCAAT
TTAATCCTGAAGAATATGATCCTGCCTTTAAAAAGTGGGCATTTGAGACCTTGCCAATTATCCCGGGTAAATGGGGGCTT
TCACCTAAAAAAGAAACAAAAAAACAGTTCAATGTCGTCATGAAACTTATCAAACAAGCTAAACTTGTTGTCATTGCAAC
CGATATTGATAGAGAGGGCGAAACTATAGCAAGAGAATTGCTGGATTTGGCAGGATTTCGAGGGCAAATAAAACGCCTTT
GGTTGTCTGCACTAGATGATACCAGTATTCGCAAAGCCTTGGGCGCACTTAAAAATAATGAGGAGACACTACCTCTTTAC
TATGCGGGACTTGCACGTAGTCGAGCTGATTGGCTTATTGGTATGAATTTCTCTCGTCTCTATACCTTATTAGCGCAACA
ACAAGGGTATCAAGGGAAACCTTTAAGTGTTGGTCGGGTACAAACTCCAACATTAAGCTTGGTTGTTAATCGTGACCGTG
AGATAAAAAACTTCATTCCTAAGCAACATTTTGCTTTGCAAGTAATGCTTTCTGATGGAAATCAGCATTTTGCTACGCAA
TATGTTATTCCGGAGCAATATTGTGATCCTGATGGACTTTGTTTGTCTGCCCAAGTTATACAAGCAGCAAATCAGCAAAT
TCGCCAATTTGGCCAAGCGAAAGTGGAATCAGTTGAAACTAAACGTGAAAGACAAAATGCCCCACTTTGCTTTGCATTAA
GTGACTTACAATCAGAAGCTAACCGCCTTTATGGACTGGGTGCGCAAAGAGTATTGGATATAGCTCAATCACTTTATGAG
ACTCACAAAGCGACAACCTATCCTAGAACAGATTGTGGTTATTTACCGGAGTCTCAGTTTGCAGAAGCGCCTCAAATTAT
CCAATGTTTGTTGCAATCCGATAATCGATTACACCCCCTTGCAGGTATGTTAAACCTTAATCAAAAATCACGAGTTTGGA
ATGATAAAAAAATTACTGCTCACCATGGCATTATTCCGACTATGATTAAAGCTGATATTAGCAAAATGTCTGATGAAGAA
TTAAAGCTCTATGATCTCATACGTCGTCGTTATTTAGCTCAATTCTTACCTGTTTCTGAAACAGATAAGACACAAATTAT
TTTGAAGTGCGGTCAACATATATTAAGTGCACGTGGGAATGTGCTTATTGCTCCAGGTTGGAAAATTCTATTTGGCAAAT
CACTTGATGAAGATGATGACGCACCTCAAGCCTTGCCGACGTTAAAGCAAGGACAAATCTGTCAGATTTCTGATTCAGAA
ATAAAAACCTTACAAACATCACCACCTAATCACTTCACGGAAGGTACATTGCTCACCGCAATGAAAAATGCAGCTCGCTT
TGTAACTGATGAGCGTTTAAAACAACGCTTACGAGAAACTGAAGGGCTTGGAACAGAAGCTACTCGGGCGGGAACGATTC
AAGGTTTGATTGATAAAGGTTTCTTGAAAAAGAAAGGTAAATCACTATTAGCGACAGATGAAGCAATGACGCTAATTGAT
AATTTACCTCAGATGTTAAAAGATCCGGGTTTAACCGCACTTTGGGAGCAAGCGCTCAATCAAATTGCTGAAAGAACGCT
TTCGCTAGAAGTGTTTATGCAAAAACAAGAAGTCTTTGTGCGGCATTTGATGGCTGATTGCCTTAAAAAGGGAATGAGTT
TGGGGAATATTGAAATTCGTAAATGCCCTAAGTGCGGTGCACCAATGATTAAAAGAAATGGTAAAAATGGGGCTTTTTTT
GGGTGTTCTGCTTATCCAAATTGCCAACATATTGAAAATATTGATAGCAAGAAGAATACTAAAAGTACAAAAAATTTAAA
GAAAAAGTCGAGTAAAAGTGTGAGTGAGCAAATTTCATCTTTACGAAGCTTATTGAACTAG

Protein sequence :
MRENIMKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGL
SPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLY
YAGLARSRADWLIGMNFSRLYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQ
YVIPEQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYE
THKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEE
LKLYDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSE
IKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLID
NLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFF
GCSAYPNCQHIENIDSKKNTKSTKNLKKKSSKSVSEQISSLRSLLN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 0.0 68
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 2e-158 52
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 2e-162 52
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 8e-154 51
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 8e-154 51
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 6e-154 51
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 2e-152 50
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 1e-143 47