Gene Information

Name : cmlA (SC052)
Accession : YP_209357.1
Strain :
Genome accession: NC_006856
Putative virulence/resistance : Resistance
Product : chloramphenicol resistance protein
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG2814
EC number : -
Position : 40607 - 41866 bp
Length : 1260 bp
Strand : -
Note : IPR001411: tetracycline resistance protein TetB; IPR001958: tetracycline resistance protein; IPR004734: multidrug resistance protein; IPR004812: drug resistance transporter Bcr/CflA subfamily; IPR005828: general substrate transporter; IPR007114: major fac

DNA sequence :
GTGAGCTCAAAAAACTTTAGTTGGCGGTACTCCCTTGCCGCCACGGTGTTGTTGTTATCACCGTTCGATTTATTGGCATC
ACTCGGCATGGACATGTACTTGCCAGCAGTGCCGTTTATGCCAAACGCGCTTGGTACGACAGCGAGCACAATTCAGCTTA
CGCTGACAACGTACTTGGTCATGATTGGTGCCGGTCAGCTCTTGTTTGGACCGCTATCGGACCGACTGGGGCGCCGCCCC
GTTCTACTGGGAGGTGGCCTCGCCTACGTTGTGGCGTCAATGGGCCTCGCTCTTACGTCATCGGCTGAAGTCTTTCTGGG
GCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTTGTTTCCACATTTGCAACAGTACGTGACATTTACGCAGGTC
GCGAGGAAAGTAATGTCATTTACGGCATACTCGGATCCATGCTGGCCATGGTCCCGGCGGTAGGCCCATTGCTCGGAGCG
CTCGTCGACATGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATCGCTGCATCTGCAGCAGCGTG
GCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCGTTAAGTGCCTGA
ACTTCTGGTTGTACACGTTGTGTTACGCCGCTGGAATGGGTAGCTTCTTCGTCTTTTTCTCCATTGCGCCCGGACTAATG
ATGGGCAGGCAAGGTGTGTCTCAGCTTGGCTTCAGCCTGCTGTTCGCCACAGTGGCAATTGCCATGGTGTTTACGGCTCG
TTTTATGGGGCGTGTGATACCCAAGTGGGGCAGCCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCTGGAGCAG
TATTGCTTGCCATCACCGAAATATGGGCTTTGCAGTCCGTGTTAGGCTTTATTGCTCCAATGTGGCTAGTGGGTATTGGT
GTCGCCACAGCGGTATCTGTGGCGCCCAATGGCGCTCTTCGAGGATTCGACCATGTTGCTGGAACGGTCACGGCAGTCTA
CTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACGTTGATCATTTCGCTGTTGCCGCGCAACACGGCTTGGCCGG
TTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTCGGTCTGTCTTGTGTTTCCCGAGTGAAGGGCTCTCGCGGCCAG
GGGGAGCATGATGTGGTCGCGCTACAAAGTGCGGAAAGTACATCAAATCCCAATCGTTGA

Protein sequence :
MSSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRP
VLLGGGLAYVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGA
LVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLM
MGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWALQSVLGFIAPMWLVGIG
VATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQ
GEHDVVALQSAESTSNPNR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cml(A)5 ACY75522.1 CmLA(5) Not tested Tn6060 Protein 5e-159 99
cmlA5 CAJ77046.1 Chloramphenicol resistance protein Not tested AbaR1 Protein 7e-159 99
cmlA9 ABZ01840.1 CmlA9 chloramphenicol efflux protein Not tested SGI2 Protein 4e-62 50
cmlA CAJ77032.1 chloramphenicol and florfenicol resistance protein Not tested AbaR1 Protein 4e-62 50
floR YP_005176183.1 florfenicol / chloramphenicol efflux protein Not tested ICEPmu1 Protein 5e-62 50
flo AAK02049.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 3e-63 49
floRc AGK06972.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 3e-63 49
floRc AGK07102.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 3e-63 49

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cmlA YP_209357.1 chloramphenicol resistance protein DQ522237.1.gene4.p01 Protein 3e-159 99
cmlA YP_209357.1 chloramphenicol resistance protein NC_010410.6003586.p0 Protein 3e-159 99
cmlA YP_209357.1 chloramphenicol resistance protein DQ984668.gene.p01 Protein 3e-159 99
cmlA YP_209357.1 chloramphenicol resistance protein AF294653.1.gene4.p01 Protein 9e-160 99
cmlA YP_209357.1 chloramphenicol resistance protein AF156486.gene.p01 Protein 4e-156 98