Gene Information

Name : thiC (ERWE_CDS_03030)
Accession : YP_197179.1
Strain : Ehrlichia ruminantium Welgevonden
Genome accession: NC_006832
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 499027 - 500694 bp
Length : 1668 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGAAAATTGACCTTAATACTATATTCCCATCTTCACGTAAAGAATACATACCAGGTAAAATCTATAAAAATATTAAAAT
AGGTATGCGCAAAGTCTCTTTCAACAATGATACTGAATCAATCTTCATATATGATACCGGAGGACCACATTCTGATCAAG
ATATACAAACCAATATAAACAATGGTATTAAAAAATTACGGCTTAATTGGATAACAGATAGGCAAGATGTAGAATATTAT
GATAGACATACAATCAATACAAATTCCAGTACAGCATTTCCTTTACAAAATAACAAAGCTTTAAAATCCAAAAGTGATAA
ACCTGTAACTCAGATGTTTTACGCAAAAAATAATATTATTACTCCAGAAATGGAATATGTTGCAATACGAGAAAACTCTT
TAATACAAAAACTTCTATCACACACACCAAATACCATAATTCCAGAAATAACTCCAGAACTTGTCAGACAAGAAGTAGCT
GCTGGTCGAGCAATTATTCCTGCAAATATTAATCATCCAGAATCAGAACCTATGATTATTGGTAAGAACTTCCTAGTAAA
AATCAATGCCAATATTGGAAACTCAGCAGTAAGTTCAGACATAAATAATGAAGTACATAAAATGATATATGCAATCATAT
ATGGTGCAGATACAGTAATGGATTTATCAACAGGAAGTCATATACATAATACTAGAGAATGGATTATTAGGAACAGCCCT
GTACCAATAGGTACAGTACCTATATACCAAGCATTGAATAAAGTAAATGGAATAGTAGGAGAACTTGATTTTAATATTTT
TAAAGAAACACTAATTGAACAAGCAGAACAAGGAGTGGATTATTTTACTATACATGCTGGTGTATTAAAAAAATACATTC
AATACACAACCAACCGGCTAACTGGCATTGTATCCAGGGGTGGAGCTATTATTGCACAATGGTGTTCTATACATAATAAA
GAGAACTTTCTCTATACAAATTTTGAGGAAATATGTGATATAATGAAAAGTTACGATATTGCTTTCTCTTTAGGAGATGG
TCTAAGGCCCGGTTCTATAGCAGATGCAAACGATAAAGCACAGTTTTTAGAATTAAAGACACTAGGAGAACTTACAGATA
TTGCATGGAAACATGATTGTCAAGTTATGATAGAAGGTCCAGGACACGTACCAATGCATTTAATAAAAGAAAATGTAGAA
AAACAGATATACTTTTGTAAAGAAGCCCCATTTTATACTTTAGGACCACTCACTACAGATATTGCTCCTGGATATGATCA
CATAACTAGTGCCATAGGTGCAGCAATGATAGGATGGTATGGTACTTCTATGTTATGTTATGTCACACCAAAAGAACACC
TTGGATTACCAAATCTCAATGATGTAAAAAATGGAGTAATTACATATAAAATCGCAGCACATGCTGCTGATCTAGCAAAA
GGTAATCCTTCCGCTTATATAAGAGATTATGCATTAAGTCATGCAAGATTTAATTTTAGATGGTATGATCAATTCAACTT
ATCACTTGATCCAGAAACAGCAAAATCTTTTCACGATGAATCTCTACCTTCTGAACATGCAAAATCTGCACATTTTTGTT
CAATGTGCGGACCAAAATTTTGCTCAATGAAATTAACACATCAGCTGCAACTTAACTCTACCGAATAA

Protein sequence :
MKIDLNTIFPSSRKEYIPGKIYKNIKIGMRKVSFNNDTESIFIYDTGGPHSDQDIQTNINNGIKKLRLNWITDRQDVEYY
DRHTINTNSSTAFPLQNNKALKSKSDKPVTQMFYAKNNIITPEMEYVAIRENSLIQKLLSHTPNTIIPEITPELVRQEVA
AGRAIIPANINHPESEPMIIGKNFLVKINANIGNSAVSSDINNEVHKMIYAIIYGADTVMDLSTGSHIHNTREWIIRNSP
VPIGTVPIYQALNKVNGIVGELDFNIFKETLIEQAEQGVDYFTIHAGVLKKYIQYTTNRLTGIVSRGGAIIAQWCSIHNK
ENFLYTNFEEICDIMKSYDIAFSLGDGLRPGSIADANDKAQFLELKTLGELTDIAWKHDCQVMIEGPGHVPMHLIKENVE
KQIYFCKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTSMLCYVTPKEHLGLPNLNDVKNGVITYKIAAHAADLAK
GNPSAYIRDYALSHARFNFRWYDQFNLSLDPETAKSFHDESLPSEHAKSAHFCSMCGPKFCSMKLTHQLQLNSTE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 6e-180 65
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 6e-180 65
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 4e-167 59