Gene Information

Name : thyA (LBA0901)
Accession : YP_193789.1
Strain : Lactobacillus acidophilus NCFM
Genome accession: NC_006814
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 875749 - 876705 bp
Length : 957 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGCAATTCTTGAACAACCATATTTAGATTTGATTAATAAAATTATGATTGAAGGTCATGATAAAAATGATCGTACAGG
AACTGGAACTAGGAGTTATTTTGGTGCTCAAATGCGCTTTGACTTATCAAAAGGGTTTCCAATTTTAACCACTAAAAAGG
TTCCATTCGGTTTAATTAAAAGTGAACTCCTATGGTTCTTACGAGGGGACACTAATATTCGTTTTTTATTAGAACATAAA
AATCATATTTGGGATGAGTGGGCATTTAAAAATTGGGTTAACAGTGATGAATATACTGGTCCTGATATGACTGATTTTGG
TTTACGAAGTCAAAGTGATCCGGAATTTAATAAAATTTATCAAGCTGAATTAAAAAAATTTGATCGACGTATCCTTGATG
ATGAGAACTTCGCCAAAAAATATGGTAATTTAGGCGACGTTTATGGTGCACAATGGCGCCATTGGCAAAAGCGAGATGGT
AGCTTTATTGATCAAATTGAAAATGTAATTGAACAAATTAAAAATAATCCAGATTCACGCAGGATGATTGTAACAGCCTG
GAATCCAGAAGATGTACCAACTAGTGCTCTTCCTCCGTGTCATGTTATGTTCCAATTTTATGTGGTAGATGGAAAAATTA
GCGTTCAGCTTTATCAGCGTAGTGGAGATATGTTTTTAGGCGTGCCATTTAATATTGCATCATATGCACTTTTATTAAAT
ATGATTGCCAGAGAAACTGGTCTGCAAGTGGGTGAATTTATTCATACATTGGGGGATGCTCATATTTATAGTAACCACTT
TAGTCAAGTGAAGGAAATGCTTAGTCGCAAGCCATATGAATCTCCACAGTTATGGCTTAATCCTGAAAAAAAACATATTG
AAGATTTTGATATGCAAGATATTAAGTTAGTGGATTATAAGCATCATGGCACAATTAAGGCGCCAGTTGCTGTTTAA

Protein sequence :
MAILEQPYLDLINKIMIEGHDKNDRTGTGTRSYFGAQMRFDLSKGFPILTTKKVPFGLIKSELLWFLRGDTNIRFLLEHK
NHIWDEWAFKNWVNSDEYTGPDMTDFGLRSQSDPEFNKIYQAELKKFDRRILDDENFAKKYGNLGDVYGAQWRHWQKRDG
SFIDQIENVIEQIKNNPDSRRMIVTAWNPEDVPTSALPPCHVMFQFYVVDGKISVQLYQRSGDMFLGVPFNIASYALLLN
MIARETGLQVGEFIHTLGDAHIYSNHFSQVKEMLSRKPYESPQLWLNPEKKHIEDFDMQDIKLVDYKHHGTIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-97 61