Gene Information

Name : guaA (GOX1950)
Accession : YP_192342.1
Strain : Gluconobacter oxydans 621H
Genome accession: NC_006677
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2138914 - 2140515 bp
Length : 1602 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACATTGACCCAGCAGGACGCCAGCACCGTCGAAAAGCTCGACGAAACCCTTCACGAAGACCGTATCCTCATTCTGGA
TTTCGGCAGCCAGGTGACGCAGCTTATTGCGCGCCGCGTCCGCGAAAGCGGCGTTTACTGCGAGATCTGGCCGTTTACGG
CGACCGAGGAAAAGATCCGCGCATTCAATCCGCGCGGCATCATCCTGTCCGGCAGCCCGGCCAGTGTGCATGACGAGAAT
GCACCACCGATTCCGAATGTGGTCTTCGCGCTGAACCGCCCCGTGCTGGGGATCTGCTATGGCCAGCAGGCGATGTGCCA
GATGCTGGGCGGCAAGGTCGAGAGCCATGAACACCGCGAATTCGGCCGCGCCTATATTGATATTGCCGAGGACTGCTCGC
TGTTCCGGGGCGTCTGGGCACGCGGCAAGCGTGAGCAGGTCTGGATGAGCCATGGCGATCGCGTCACGCAGCTTCCGCCG
GGCTTCCGCGCCGTTGCCCATTCCGAAGGCGCACCGTTCGCGATCATCGCGGATGAGGGACGTCGTCTGTATGGCGTGCA
GTTCCATCCGGAAGTCGTGCATACGCCGCATGGTGCAGCCCTGATCCGCAACTTCACGCATAATGTTGCAGGTTGCAGCG
GAACCTGGACGATGGCTGGCTTCCGTGAACTGGAAATCGCGCGCATCCGCAAGCAGGTCGGTTCGGGTCGTGTGATCTGT
GGTCTGTCGGGTGGTGTAGACAGCTCCGTTGCGGCCAAGCTGATTCATGATGCGATCGGCGATCAGCTGACCTGCATTTT
CGTGGATCCGGGCATCATGCGGACCGGCGAGGCTGACGAAGTCGTCAAGACGTTCCGTGGCCGCTTCAATATCCGTCTCG
TGCATCGTGACGCCTCCGAGCTGTTCCTGAAGGAACTGGCTGGCGTGACGGACCCGGAAACGAAGCGCAAGACGATCGGT
CGCCTGTTTATCGAGGTCTTCGAGGAAGAGGCTGCGAAGCTGGGTGGCGCTCAGTTCCTGGCTCAGGGCACGCTGTATCC
GGACGTGATCGAGAGCGTGAGTTTCTCGGGTGGTCCGTCCGTGACCATCAAGTCCCATCATAATGTCGGCGGTCTGCCGG
ACCGCATGAACATGGAACTGGTCGAACCGCTGCGTGAGCTGTTCAAGGACGAGGTCCGTATGCTTGGCCGTGAGCTGGGT
ATTCCGGAAAGCATCGTCGGGCGGCATCCGTTCCCGGGGCCGGGACTGGCGATCCGTATTCCGGGTGATGTCACCAAGGA
AAAGCTGGATCTGCTGCGCAAGGTGGACGCGATCTATCTTGAGGAAATCCGTCGCGCCGGTCTGTATGACGCAATCTGGC
AGGCTTTCGCGGTTCTGCTTCCGGTGCGGACGGTCGGCGTCATGGGCGATGGCCGGACCTACGATCAGGCCTGCGCCCTG
CGCGCCGTGACCAGCACGGATGGCATGACTGCGGAAGTCTATCCGTTCGACTTCGCATTCCTGAACCGGGTGGCCGGGCG
TATCGTCAACGAGGTTCGCGGCATCAACCGCGTGACTTATGACATCACGTCCAAGCCGCCGGGCACGATTGAGTGGGAAT
GA

Protein sequence :
MTLTQQDASTVEKLDETLHEDRILILDFGSQVTQLIARRVRESGVYCEIWPFTATEEKIRAFNPRGIILSGSPASVHDEN
APPIPNVVFALNRPVLGICYGQQAMCQMLGGKVESHEHREFGRAYIDIAEDCSLFRGVWARGKREQVWMSHGDRVTQLPP
GFRAVAHSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALIRNFTHNVAGCSGTWTMAGFRELEIARIRKQVGSGRVIC
GLSGGVDSSVAAKLIHDAIGDQLTCIFVDPGIMRTGEADEVVKTFRGRFNIRLVHRDASELFLKELAGVTDPETKRKTIG
RLFIEVFEEEAAKLGGAQFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPDRMNMELVEPLRELFKDEVRMLGRELG
IPESIVGRHPFPGPGLAIRIPGDVTKEKLDLLRKVDAIYLEEIRRAGLYDAIWQAFAVLLPVRTVGVMGDGRTYDQACAL
RAVTSTDGMTAEVYPFDFAFLNRVAGRIVNEVRGINRVTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-135 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-135 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-135 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-119 52