Gene Information

Name : aadE (SEA0012)
Accession : YP_187541.1
Strain :
Genome accession: NC_006663
Putative virulence/resistance : Resistance
Product : aminoglycoside 6-adenylyltransferase
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.-
Position : 9114 - 9953 bp
Length : 840 bp
Strand : -
Note : identified by similarity to GP:12957029; match to protein family HMM PF04439

DNA sequence :
GTGACCCTTGAGGGGTCACGCGCAAATATTAATATACCTAAAGATGAATTTCAGGATTATGATATTACATATTTTGTAAG
TGATATAGAACCGTTTATATCTAATGATGACTGGCTTAATCAATTTGGGAATATAATAATGATGCAAAAGCCGGAGGATA
TGGAATTATTCCCACCTGAAGAAAAGGGATTTTCCTATCTTATGCTATTTGATGATTACAATAAAATTGATCTTACCTTA
TTGCCCTTGGAAGAGTTAGATAATTACCTAAAGGGCGATAAATTAATAAAGGTTCTAATTGATAAAGATTGTAGAATTAA
AAGGGACATAGTTCCGACTGATATAGATTATCATGTAAGAAAGCCAAGCGCAAGGGAGTATGATGATTGCTGCAATGAAT
TTTGGAATGTAACACCTTATGTTATTAAAGGATTGTGCCGTAAGGAAATTTTATTTGCTATTGATCATTTTAATCAGATT
GTTCGCCATGAGCTGCTGAGAATGATATCATGGAAGGTCGGCATCGAAACAGGCTTTAAATTAAGTGTAGGCAAGAACTA
TAAGTTTATTGAAAGGTATATATCCGAGGATTTGTGGGAGAAACTTTTGTCCACCTACCGGATGGATTCCTATGAAAACA
TATGGGAAGCATTATTTCTATGCCATCAATTGTTCAGGGCGGTATCCGGTGAGGTGGCGGAAAGGCTTCATTATGCCTAT
CCGGAGTATGATAGGAATATAACAAAATATACCAGGGACATGTATAAAAAATACACTGGTAAAACCGGCTGCCTGGATAG
CACATATGCCGCTGATATAGAAGAGAGGCGGGAACAGTGA

Protein sequence :
MTLEGSRANINIPKDEFQDYDITYFVSDIEPFISNDDWLNQFGNIIMMQKPEDMELFPPEEKGFSYLMLFDDYNKIDLTL
LPLEELDNYLKGDKLIKVLIDKDCRIKRDIVPTDIDYHVRKPSAREYDDCCNEFWNVTPYVIKGLCRKEILFAIDHFNQI
VRHELLRMISWKVGIETGFKLSVGKNYKFIERYISEDLWEKLLSTYRMDSYENIWEALFLCHQLFRAVSGEVAERLHYAY
PEYDRNITKYTRDMYKKYTGKTGCLDSTYAADIEERREQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
aadE AFJ97257.1 streptomycin aminoglycoside 6-adenyltransferase Not tested Not named Protein 2e-103 97
aadE YP_003446812.1 streptomycin aminoglycoside 6-adenyltransferase Not tested The aminoglycoside resistance gene cluster Protein 5e-123 93
SSU05_0957 YP_001198323.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 8e-110 89
SSU98_0964 YP_001200522.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 8e-110 89
aadE AFJ97264.1 putative adenyltransferase Not tested Not named Protein 2e-81 64

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aadE YP_187541.1 aminoglycoside 6-adenylyltransferase NC_006663.1.orf0.gen Protein 2e-129 100
aadE YP_187541.1 aminoglycoside 6-adenylyltransferase AJ489618.1.orf2.gene Protein 3e-99 88
aadE YP_187541.1 aminoglycoside 6-adenylyltransferase FN594949.1.gene25.p0 Protein 1e-81 65