Gene Information

Name : guaA (ABC0936)
Accession : YP_174436.1
Strain : Bacillus clausii KSM-K16
Genome accession: NC_006582
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1014213 - 1015760 bp
Length : 1548 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAAGTAACGAATCATGAAACGATTGTTGTCCTTGACTTTGGTGGGCAATACAATCAACTGATCACAAGACGTATCCG
CGACCTCGGTGTGTATAGCGAACTGCATTCGCACAAACTGACGGCGGATGAATTAAAAGAAATGAACCCAATCGGCATTA
TCTTTTCGGGCGGGCCTAACAGCGCGTATGTAGAAGGCTCTCCTAAATGCGACCCTGCCATTTATGATTTAGGCATTCCG
ATTTTAGGGATTTGTTATGGCGTCCAATTAATGACGCACCACTTTGGCGGCAAAGTCGACAAGGCTTCCCATCGTGAATA
CGGAAAAGCGTTACTAAATGTCGAAAACCAATCGCCGCTCTTTAAAGGCTTGCCCATTGAGCAAACCGTTTGGATGAGCC
ATGGCGACAAAATTGTGGCTCCGCCAGAGGGCTTTACCGTCGACGCTTCCAATCCTTCTTGCCCAGTTGCAGCTATGAGC
GACGAGTCCCGCAACTTGTACGGCGTGCAGTTTCATCCTGAAGTGCGCCATTCCGAATTTGGCAATGACCTTTTGAAAAA
CTTTGCCTTTGACATTTGCGGCGCTAAAGGCGATTGGTCAATGGAAAACTTCATTGAAGAGGAAATCAAGAAAATCCGCG
AGCAAGTAGGCGACCGCCACGTCCTGTGTGCATTAAGCGGTGGCGTTGACTCCTCTGTAGTAGCGGTGCTCATCCATAAA
GCAATTGGCGATCAATTGACATGCATGTTCATTGACCATGGCTTGCTTCGCAAAGGGGAAGCAGAAAGCGTCATGGAAAC
ATTCACCCAAGGCTTTAACATGAATGTCGTCAAAATTGACGCATCAGAACGGTTCTTGACTAAATTAAAAGGCGTCACCG
ATCCAGAACAAAAACGGAAAATTATCGGCAACGAATTTATTTACGTCTTTGATGAAGAATCAGCAAAACTAAAAGATAAG
AAAATGGACTTCCTCGCTCAAGGAACACTCTACACTGATATCATTGAGTCAGGAACAGACACGGCCCAAACGATTAAATC
GCACCATAACGTTGGCGGCTTGCCAGAAGACATGGCGTTTGAATTAATTGAGCCACTCAATGCGCTATTTAAAGACGAAG
TGCGTGCTCTTGGCACAGAACTTGGCATTCCAGATGAGATCGTATGGCGCCAACCATTCCCTGGCCCAGGCCTCGGCATT
CGCGTCCTCGGCGAAATTACCGATGAGAAGCTAAAAATTGTCCGTGAATCAGACGCAATCTTGCGTGAAGAAATCAAAAA
AGCCGGGCTTGACCGCGAAATTTGGCAATACTTTACGGCACTGCCGAATATGCGCAGCGTTGGCGTCATGGGCGACACAC
GCACATACGATTACACCGTCGGCATCCGCGCCGTTACTTCCATTGACGGCATGACGTCAGATTGGGCGCGCATTCCATGG
GATGTGCTTGAAATCATCTCCACCCGGATCGTCAACGAAGTCGAACACGTCAACCGGATTGTGTACGACATTACGAGCAA
GCCGCCTTCCACGATTGAGTGGGAGTAA

Protein sequence :
MQVTNHETIVVLDFGGQYNQLITRRIRDLGVYSELHSHKLTADELKEMNPIGIIFSGGPNSAYVEGSPKCDPAIYDLGIP
ILGICYGVQLMTHHFGGKVDKASHREYGKALLNVENQSPLFKGLPIEQTVWMSHGDKIVAPPEGFTVDASNPSCPVAAMS
DESRNLYGVQFHPEVRHSEFGNDLLKNFAFDICGAKGDWSMENFIEEEIKKIREQVGDRHVLCALSGGVDSSVVAVLIHK
AIGDQLTCMFIDHGLLRKGEAESVMETFTQGFNMNVVKIDASERFLTKLKGVTDPEQKRKIIGNEFIYVFDEESAKLKDK
KMDFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMAFELIEPLNALFKDEVRALGTELGIPDEIVWRQPFPGPGLGI
RVLGEITDEKLKIVRESDAILREEIKKAGLDREIWQYFTALPNMRSVGVMGDTRTYDYTVGIRAVTSIDGMTSDWARIPW
DVLEIISTRIVNEVEHVNRIVYDITSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 0.0 73
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 0.0 73
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 0.0 73
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-136 52