Gene Information

Name : aadK (ABC0860)
Accession : YP_174360.1
Strain : Bacillus clausii KSM-K16
Genome accession: NC_006582
Putative virulence/resistance : Resistance
Product : aminoglycoside 6-adenylyltransferase
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.-
Position : 930237 - 931091 bp
Length : 855 bp
Strand : +
Note : streptomycin adenyltransferase

DNA sequence :
TTGCGAAGCGAACAAGAAATGATGACGCTGTTTTTAGATTTTGCGAAAAACGATGAGCGAATTCGCTTAGTCACGTTAGA
AGGGTCACGTACAAATAAAGCGATCACTCCTGATAAATTCCAGGATTATGATATTTCTTACTTTGTAACGGATATCGACT
CGTTTAAAGAAAATGACCAGTGGCTTGATCCATTCGGAAAAGCAATAATGATGCAAAAGCCAGAGGACATGAAGCTTTTT
CCGCCTGAATTAGGCAATTGGTTTTCTTATATTATTCTTTTTGAGGATGGCAACAAATTGGATTTAACCCTTATTCCTCT
CAACGAAGTCAAAGATTACTTCTCTCAAAGTGATGGACTAGTTGAGGTTTTGCTTGATAAAGATCGGCTCGTCAAAAACG
AAATCGTTGCTGATGATCGCCACTATTGGCTAAAAAAGCCAACAGAAAGAGAATTTGATGATTGTTGCAATGAATTCTGG
ATGGTTTCCACCTATGTGGTCAAAGGATTAGCCAGAAAGGAAATCCTCTTTGCTATCGACCATTTAAACGGAATTGCTCG
GCCTAATTTGTTGAGAATGATGGCTTGGTACGTGGGCTCAGAGCGAGGATATACGTTTAGTGTGGGGAAAAATTATAAAT
TTATTGATCGCTATCTTCCTAAAGAGGATTGGGAAGCACTGCTTTCGACTTATTGTGAGAAGGGCTACGCAGAAACGTGG
CAATCTTTATTTACTTGTTATGAGCTTTTTAGAAAATACTCGAAAGGATTGTCGGCCAGTCTTGGCTACAACTATCCAGA
TTACGACGAAGCGATTACAGCCTATTCAGCTAGTATCTACGATTCACTGCCATAA

Protein sequence :
MRSEQEMMTLFLDFAKNDERIRLVTLEGSRTNKAITPDKFQDYDISYFVTDIDSFKENDQWLDPFGKAIMMQKPEDMKLF
PPELGNWFSYIILFEDGNKLDLTLIPLNEVKDYFSQSDGLVEVLLDKDRLVKNEIVADDRHYWLKKPTEREFDDCCNEFW
MVSTYVVKGLARKEILFAIDHLNGIARPNLLRMMAWYVGSERGYTFSVGKNYKFIDRYLPKEDWEALLSTYCEKGYAETW
QSLFTCYELFRKYSKGLSASLGYNYPDYDEAITAYSASIYDSLP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
aadE YP_003446812.1 streptomycin aminoglycoside 6-adenyltransferase Not tested The aminoglycoside resistance gene cluster Protein 6e-80 58
SSU05_0957 YP_001198323.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 4e-79 57
SSU98_0964 YP_001200522.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 4e-79 57
aadE AFJ97264.1 putative adenyltransferase Not tested Not named Protein 2e-72 56
aadE AFJ97257.1 streptomycin aminoglycoside 6-adenyltransferase Not tested Not named Protein 2e-55 55
SAKOR_00397 YP_008490581.1 Aminoglycoside 6-adenylyltransferase Not tested vSa¥á Protein 2e-43 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aadK YP_174360.1 aminoglycoside 6-adenylyltransferase FN594949.1.gene25.p0 Protein 5e-73 57
aadK YP_174360.1 aminoglycoside 6-adenylyltransferase NC_006663.1.orf0.gen Protein 4e-73 57
aadK YP_174360.1 aminoglycoside 6-adenylyltransferase AJ489618.1.orf2.gene Protein 3e-57 55