Gene Information

Name : thyA (ABC2955)
Accession : YP_176450.1
Strain : Bacillus clausii KSM-K16
Genome accession: NC_006582
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3077129 - 3077923 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGAACAATACTTGCAGTTATGCGAGCACGTTTTGCAAAACGGCTCGCCAAAATCAGATCGGACAGGCACTGGCACCAT
TAGTGTATTTGGTTACCAAATGCGCTTTGATTTAGAAAAGGGTTTTCCAATTGTCACAACGAAAAAATTGCATATGCGTT
CGATCATCCATGAATTGCTTTGGTTTCTAAAAGGCGACACGAACATCCGTTATTTGCAAGAAAATGGCGTTCGTATTTGG
AACGAATGGGCGGATGAAAACGGCGACCTTGGGCCTGTTTACGGAAAACAATGGCGCTCCTGGGAAGGGGCAAACGGCAA
AACAGTCGACCAAATTACTGAAGTGGTTGAGCAAATAAAAACGAATCCGAATTCTCGCCGCTTAATTGTCAATGCGTGGA
ATGTCGCGGAGATTGAAGAAATGGCGCTTGCGCCATGCCATTGCTTGTTTCAGTTTTACGTAAACGACGGAAAACTTTCT
TGCCAATTGTACCAGCGCAGTGCCGATATTTTTCTTGGCGTTCCTTTTAATATATCGTCTTATGCCCTGTTAACGATGAT
GATGGCCCAAGTGTGCGGATTAAAGCCTGGCGAATTTATCCATACGTTTGGCGATGCCCATTTGTACAACAACCATATTG
AACAGACGAAGCTTCAATTAACGCGTAAACCAAAACAGCTACCTACGATGCATATCAATCCAGAGGTAACAGACCTGTTT
GCGTTTACTTACGATGATTTTGAACTGAAACATTATGATCCTTATCCGCATATTAAAGCAGAGGTGTCCGTATGA

Protein sequence :
MEQYLQLCEHVLQNGSPKSDRTGTGTISVFGYQMRFDLEKGFPIVTTKKLHMRSIIHELLWFLKGDTNIRYLQENGVRIW
NEWADENGDLGPVYGKQWRSWEGANGKTVDQITEVVEQIKTNPNSRRLIVNAWNVAEIEEMALAPCHCLFQFYVNDGKLS
CQLYQRSADIFLGVPFNISSYALLTMMMAQVCGLKPGEFIHTFGDAHLYNNHIEQTKLQLTRKPKQLPTMHINPEVTDLF
AFTYDDFELKHYDPYPHIKAEVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 3e-78 60