Gene Information

Name : lysU (FTT_0192)
Accession : YP_169253.1
Strain : Francisella tularensis SCHU S4
Genome accession: NC_006570
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 208813 - 210543 bp
Length : 1731 bp
Strand : +
Note : Similar to SYK2_ECOLI (P14825) Lysyl-tRNA synthetase, heat inducible, from E. coli (504 aa). FASTA: opt: 2003 Z-score: 2242.9 E(): 4.9e-117 Smith-Waterman score: 2003; 61.066 identity in 488 aa overlap

DNA sequence :
TTGGGGCTACTAATTGCTAATGTGCAACAAATAATTACAGGGTTTAAAATGAGTAGTAAATTAAAAGATTTGATAAAAAC
AACGATAAAAGAATATTTAGAAGCTAATGATATCACAGTTAAAGATGCTATTAGAGGCAAGATTAGAGAGCAGATTAGTG
AGTTTTTAGGCGAGGTAAGCGAGATAAATGAGCAGGTTAAAGAACAAATTTCAGCGCTTGTGAAAAAGCATGTAACAGAA
TTACAAGAAAGCTCACAAATTGCTTTAAGAAAAGAAAAGCTAAAAACTTTAGCTCAGCAAAATAATGGCATAAGCCATCC
AAATAGTTTCCGAAGAAATGCTGTTGCTATAGAGTTACAGGCTCGCTATGCTGATAAGACTAAGCAAGAATTAGAAGAGC
TAGATAATAAACAACAATATAGTTTGACAGGTAGAGTAGTTCTACGCCGTGTCATGGGTAAAGCATCTTTTATAACACTA
CAAGATTATACTGGTAGAATCCAAGTTTATCTAAAAAAGAGTGACTTGCCAGATGGGCAATATGAAACTTTTAAGAATCT
ATGTGACTTGGGTGATATAGTTGGTATTACTGGTACTATGTTTAAGACAAATACTGGTGAACTTTCTGTTGAAGCAAATC
ACTTTGAGATTTTGACAAAGGCAATTCGTCCTTTGCCTGATAAATTCCATGGTTTGGCAGATCAAGAAATGAGATATCGT
CAAAGATATGTTGATTTAATTACAAATGAAAAGGCAAGAGAAGTCTTTAAAGTACGCTCAAAAGTTGTGAACTTTATCCG
TAACTATTTTGATAGACTAGATTTTATGGAAGTAGAGACGCCGATGATGCATGTTTTGCAAGGTGGTGGTGCTGCTAAGC
CATTTAAAACTCATCACAATGCTTTGGATATGCCTTTATATTTGCGTATTGCTCCAGAACTTTATCTAAAAAGACTAGTT
GTTGGTGGTTTTGAGCGAGTTTATGAGATAAACCGTAATTTTAGAAACGAAGGTGTATCTTCACGCCATAATCCAGAATT
TACAATGCTAGAGTTCTATATGGCGTATGCTGATTATAATGACCTTATGGATCTAACAGAAGATATGCTATCTAAACTTG
TACAGGAAGTAATTGGTAGCGAGATACTTGAGTATGGTGAGTATAAAATCAACTTTGGTGGTAAGTACGAACGAATCTCA
ATGGTTGACTCAATTGTTAAGTATAATGATGATATTACCAAAGAAGATTTAGTAACATTTGAATCTGCTAAAAAGATTGC
TGAGAAACTAAAAATAAAAGTTGAAGCTTACCATGAACTTGGACATTTGATAAACGAAATATTTGAAGAAACTGTCGAGC
ATCAGCTTATTCAACCGACATTTATTACAGATTATCCAGCTGTAGTTTCACCATTGGCGCGTAGACAAGACGGTAACCCT
GAGTTTACCGATAGATTTGAGTTCTTTATTGGAGCACGTGAAGTTGCTAACGGCTTCTCTGAGCTAAATGATGCTGAAGA
TCAAGCAGAGCGTTTCAGAAAACAGGTTGAAGCTGCGGCATCTGGAGATGATGAAGCTATGCCTTATGATAAAGACTATA
TCCGCGCACTAGAGTATGGTATGCCTCCTACAGCGGGACAAGGAATCGGTATTGATAGACTGGTAATGTATCTAACAAAC
TCTCAATCAATTAGAGATGTGATTCTATTTCCGCATATGAAGCCTGAGTAA

Protein sequence :
MGLLIANVQQIITGFKMSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTE
LQESSQIALRKEKLKTLAQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITL
QDYTGRIQVYLKKSDLPDGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYR
QRYVDLITNEKAREVFKVRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGGAAKPFKTHHNALDMPLYLRIAPELYLKRLV
VGGFERVYEINRNFRNEGVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERIS
MVDSIVKYNDDITKEDLVTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNP
EFTDRFEFFIGAREVANGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTN
SQSIRDVILFPHMKPE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 6e-138 56
lysS YP_005163386.1 lysyl-tRNA synthetase Not tested Not named Protein 5e-85 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysU YP_169253.1 lysyl-tRNA synthetase VFG1668 Protein 3e-138 56