Gene Information

Name : wbtE (FTT_1460c)
Accession : YP_170397.1
Strain : Francisella tularensis SCHU S4
Genome accession: NC_006570
Putative virulence/resistance : Virulence
Product : UDP-glucose/GDP-mannose dehydrogenase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0677
EC number : 1.1.1.-
Position : 1510853 - 1512163 bp
Length : 1311 bp
Strand : -
Note : Similar to Q8EMC3 Vi polysaccharide biosynthesis from Oceanobacillus iheyensis (437 aa). FASTA: opt: 1817 Z-score: 2048.6 E(): 2.9e-106 Smith-Waterman score: 1817; 59.268 identity in 437 aa overlap

DNA sequence : 
ATGAGTTTATATGAGGATATAGTCGCTAAAAGAGAAAAGGTTTCATTGGTTGGCTTGGGTTATGTTGGTTTACCAATAGC
TATTGCATTTGCAAAAAAAATAGATGTGTTAGGATTTGATATTTGTGAAACAAAAGTTCAACATTATAAGGATGGTTTTG
ATCCAACAAAAGAAGTAGGAGATGAGGCTGTCAGAAATACGACAATGAAATTTAGTTGTGATGAAACAAGTCTTAAAGAG
TGTAAATTTCATATTGTTGCAGTTCCTACACCAGTTAAAGCAGATAAAACTCCTGATTTGACGCCGATTATTAAGGCAAG
TGAGACGGTTGGTAGGAATCTTGTCAAAGGCGCTTATGTTGTGTTTGAATCAACTGTTTATCCTGGTGTTACAGAAGATG
TTTGCGTACCAATACTTGAAAAAGAGTCTGGCTTGAGGTCTGGTGAAGATTTCAAAGTTGGTTACTCTCCTGAGAGGATA
AATCCTGGTGATAAGGTTCATAGGTTAGAAACAATTATCAAAGTAGTATCTGGTATGGATGAAGAGTCTTTAGATACTAT
AGCAAAAGTTTATGAGCTAGTAGTAGACGCAGGAGTTTATAGAGCTAGTAGTATAAAAGTGGCTGAAGCTGCTAAGGTTA
TAGAAAACTCTCAAAGAGATGTTAATATAGCTTTTGTTAATGAGTTATCGATAATATTTAATCAGATGGGTATTGATACT
CTAGAGGTTTTAGCAGCAGCTGCAACTAAATGGAATTTCTTAAACTTTAAGCCTGGTCTTGTTGGTGGACATTGTATTGG
TGTTGACCCATATTACCTAACGTACAAGGCAGCTGAGCTTGGATATCATTCTCAGGTAATATTATCTGGTCGTAGGATAA
ATGATAGTATGGGTAAATTTGTAGTTGAGAATTTAGTCAAAAAACTGATATCTGCAGATATACCTGTTAAGCGAGCTAGA
GTAGCAATTTTCGGCTTTACTTTTAAAGAAGACTGTCCTGACACTAGGAATACTCGAGTTATAGATATGGTAAAAGAGCT
CAACGAGTATGGTATAGAGCCATATATTATAGATCCGGTAGCTGATAAAGAAGAGGCTAAACATGAGTATGGACTTGAGT
TTGATGATCTAAGTAAAATGGTCAATCTAGATGCGATCATTATTGCTGTTAGTCACGAACAGTTTAAAGATATAACAAAG
CAACAGTTTGATAGGCTATATGCGCATAATTCTAGAAAGATTATATTTGACATCAAAGGTAGTTTAGATAAATCTGAGTT
TGAAAAAGATTATATTTATTGGAGATTGTAG

Protein sequence : 
MSLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVGDEAVRNTTMKFSCDETSLKE
CKFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYVVFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERI
NPGDKVHRLETIIKVVSGMDEESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDT
LEVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYHSQVILSGRRINDSMGKFVVENLVKKLISADIPVKRAR
VAIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPVADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITK
QQFDRLYAHNSRKIIFDIKGSLDKSEFEKDYIYWRL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cap1L AAA64651.1 type 1 capsule synthesis gene Virulence SCCcap1 Protein 1e-110 54
tviB NP_458740.1 Vi polysaccharide biosynthesis protein, UDP-glucose/GDP-mannose dehydrogenase Virulence SPI-7 Protein 1e-102 54
tviB NP_807945.1 VI polysaccharide biosynthesis UDP-glucose/GDP-mannose dehydrogenase Virulence SPI-7 Protein 1e-102 54

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
wbtE YP_170397.1 UDP-glucose/GDP-mannose dehydrogenase VFG0431 Protein 5e-103 54