Gene Information

Name : GK0867 (GK0867)
Accession : YP_146720.1
Strain : Geobacillus kaustophilus HTA426
Genome accession: NC_006510
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 884551 - 885732 bp
Length : 1182 bp
Strand : +
Note : catalyzes the formation of L-homocysteine from cystathionine

DNA sequence :
ATGGAACAGGAATGGGCGTTTTCGACGAAACTGCTCCATAACGAATGGAAAGTCGACCGCGAAACGGGGGCGGTGAGCGT
GCCGATCCAGCACGCCTCCACGTTCCATCAGTTCGATTTCGATTCATTCGGCAAATACGACTACAGCCGCTCCAGCAACC
CGACGCGCGAGGCGCTTGAGGAAACGATCGCGGCGTTAGAAGGCGGAACGCGCGGGTTTGCGTTCGCCTCTGGCATGGCG
GCTATTTCAACGGCGTTTTTGCTTCTCTCAAAAGGCGACCACGTGCTCGTGACCGAAGACGTCTACGGCGGCACGTACCG
GATGATTACGGAGGTGCTCGGCCGCTTTGGCATTGAATATACGTTTGTCGATATGACCGATTTAAACGCAGTGGCGGAAA
ACATCCGGCCGAACACGAAAGTCATTTATATGGAAACGCCGTCCAATCCATTGTTAAAAGTGACCGATATTCAAGGCGTC
GTCAAGTTGGCGAAGGCGCATGGCTGTTTGACATTCTTGGATAATACGTTCATGACGCCGGCGTTGCAGCGGCCGCTTGA
TCTTGGAGTCGATGTCGTCCTTCACAGCGCCACGAAATTTTTAGCCGGCCATAGCGACGTCGTCGCCGGGCTGGCGGTCG
TGAAAGACGAGGAATTGGGAAAAGAATTGTACAAACTGCAAAACGCGTTTGGCGCCGTCCTTGGCGTCCAAGATGCGTGG
CTTGTGCTGCGGGGATTAAAAACGCTCCACGTTCGGCTGAAGCAGTCGTCTGAATCAGCGGCCGCCATCGCCAAGTATTT
GGCTTGTCATCCAAAGGTCGAAAAAGTGTATTATCCGGGGCTGGAGAACCACCCAGGCCATGACATCCAGCGCCATCAGG
CGGCCGGGTTTGGCGCTGTGCTGTCGTTCCGTTTAGCCGATGAAGAAGCGGCTCGGACGTTCGTCCGAAACGTCCGCTTG
CCGGTGTTTGCTGTCAGCCTTGGGGCGGTCGAGTCAATTTTATCGCACCCAGCGAAAATGTCGCATGCGGCGATGCCAAA
AGAAGAGAGGCTCCGGCGCGGCATTACCGACGGCTTGTTGCGGCTGAGCGTCGGGCTTGAGGATGTCAACGATTTGATCG
CCGATTTTGAGCAGGCGTTGTCGTTTGTCAATGAGCATCCATCGGTCGTTCCGACGCGGTAA

Protein sequence :
MEQEWAFSTKLLHNEWKVDRETGAVSVPIQHASTFHQFDFDSFGKYDYSRSSNPTREALEETIAALEGGTRGFAFASGMA
AISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLGRFGIEYTFVDMTDLNAVAENIRPNTKVIYMETPSNPLLKVTDIQGV
VKLAKAHGCLTFLDNTFMTPALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKELYKLQNAFGAVLGVQDAW
LVLRGLKTLHVRLKQSSESAAAIAKYLACHPKVEKVYYPGLENHPGHDIQRHQAAGFGAVLSFRLADEEAARTFVRNVRL
PVFAVSLGAVESILSHPAKMSHAAMPKEERLRRGITDGLLRLSVGLEDVNDLIADFEQALSFVNEHPSVVPTR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-93 56
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-86 50
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-88 50

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GK0867 YP_146720.1 cystathionine beta-lyase BAC0207 Protein 6e-67 43