Gene Information

Name : GK0866 (GK0866)
Accession : YP_146719.1
Strain : Geobacillus kaustophilus HTA426
Genome accession: NC_006510
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 883444 - 884547 bp
Length : 1104 bp
Strand : +
Note : catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity

DNA sequence :
ATGGAGAAACTGGAGACGTTGTTAGCGCAAATTGGCAACCGGAGCGAAACGGTGACGGGGACGGTCAACCCGCCGGTTTA
TTTTTCCACCGCCTACCGCCATGCCGGCATCGGAGAGTCGACTGGGTTTGACTACATCCGCACCGGCAACCCCACGCGCA
AAATCGTCGAAGAAGCAATCGCGAGACTGGAAGGCGGCGACCAAGGCTATGCGTTCAGCTCCGGCATGGCCGCCATTCAG
ACGGTGCTCGCCTTGTTTGAGAGCGGAGATGAGTTTCTCGTATCGGCCGACCTTTACGGCGGCACGTACCGCCTGTTTGA
GCGCGGCTGGCGCAAGTATGGTCTTGGATTCCATTACGTCGATTTTGCTGATCTCGCTGCGGTGGAAGCGTGTATCACCG
AAAAAACGAAAGCGATTTTCCTGGAAACACCGACGAACCCGCTTATGCATGAGACCGATATCCGCGCCGTCTCCGAATTC
GCCAAGCGGCATGGGCTTTTGTTGATCGTTGACAACACGTTTTATACACCGGTGCTTCAACGCCCGATCGAACAAGGCGC
CGATATTGTCATCCACAGCGCCACGAAATATTTAGGCGGCCATAACGACGTGTTGGCTGGCCTTGTCGTCGCCAAGGGCG
AGGAGCTCTGTCAACGCCTGGCCGAGTATCAGAACGCCATCGGCGCGGTTTTGTCGCCGTTTGATTCGTGGCTGTTGATT
CGCGGGATGAAAACGCTGGCGCTAAGGATGCGCCAGCATGAAGAAAACGCCAAGCGCATCAGCGCCTTTTTGCGCGAACA
TGAAGATGTTACAGACGTCTTATATCCAGGAAGAGGCGGGATGCTGTCGTTCCGGATTGCCGATGAAAAGTGGGTGAACG
GGTTTTTAAAAAGCTTGCGCCTCATTACGTTCGCGGAAAGCCTGGGCGGAGTCGAAAGCTTTATTACGTACCCAGCGACG
CAGACGCATGCGGACATTCCTGAGGAAATCCGCATCCAAAACGGTATTTGCAACCGGCTGCTCCGTTTCTCGGTCGGCAT
TGAGCACGCTGACGATTTGATCGCCGATTTGGCGCAGGCATTGAAAAACATGAAAGAGGTGTAA

Protein sequence :
MEKLETLLAQIGNRSETVTGTVNPPVYFSTAYRHAGIGESTGFDYIRTGNPTRKIVEEAIARLEGGDQGYAFSSGMAAIQ
TVLALFESGDEFLVSADLYGGTYRLFERGWRKYGLGFHYVDFADLAAVEACITEKTKAIFLETPTNPLMHETDIRAVSEF
AKRHGLLLIVDNTFYTPVLQRPIEQGADIVIHSATKYLGGHNDVLAGLVVAKGEELCQRLAEYQNAIGAVLSPFDSWLLI
RGMKTLALRMRQHEENAKRISAFLREHEDVTDVLYPGRGGMLSFRIADEKWVNGFLKSLRLITFAESLGGVESFITYPAT
QTHADIPEEIRIQNGICNRLLRFSVGIEHADDLIADLAQALKNMKEV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-70 43
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-69 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GK0866 YP_146719.1 cystathionine gamma-synthase BAC0207 Protein 5e-54 41