Gene Information

Name : guaA (GK0254)
Accession : YP_146107.1
Strain : Geobacillus kaustophilus HTA426
Genome accession: NC_006510
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 272636 - 274168 bp
Length : 1533 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAACCAAGAAATGATCGTCGTCTTGGACTTTGGCAGTCAATATAACCAGCTGATTACCCGCCGCATCCGAGAGTTTGG
CGTCTACAGCGAACTGCATCCGCACACGATCCGTGCTGAGGAAATTCGTGCGCTGAACGCCAAAGGAATCATTTTCTCGG
GCGGTCCAAACAGCGTGTATGATGAACAAGCGTTTACATGCGACCCAGCGATTTTTGAGCTGGGGCTGCCGATTTTAGGG
ATTTGCTACGGGATGCAGCTGATGGCGCATCATTTAGGAGGTAAGGTGGAAAAAGCGACGCACCGTGAATATGGCAAAGC
GCTCATCCAAGTGAAAAACGATTCTTTGCTTTTTCATGGTTTGCCGGACGAGCAAGTCGTTTGGATGAGCCACGGCGATT
TGGTGACCGCTCCGCCGGCTGGTTTCGCTGTCGATGCGACGAGCCCTTCGTGCCCGATTGCTGCGATGAGTGACGAACGG
CGAAAATGGTATGGAGTGCAATTCCATCCAGAAGTGCGCCACTCGGTATACGGCAATGATCTATTGAAGAAATTTGTCTT
TGAGGTATGCGGCTGCCGGGGCGACTGGACGATGGAAAACTTTATTGATGAGCAGGTGCGCCGCATCCGTGAACAAGTGG
GCGGAAAAAAAGTGCTGTGCGCCTTAAGCGGCGGAGTCGATTCGTCGGTTGCTGCCGTTTTGGTGCACCGCGCCATTGGC
GATCAACTTACTTGTATTTTCGTCGACCATGGCCTTTTGCGCAAAGGTGAAGCCGAAAGCGTCATGAAGACGTTCCGTGA
GCAGTTCCAAATGAATGTCATTAAAGTTGATGCGAAAGACCGCTTTTTGGCGAAACTCAAAGGGGTTACGGACCCGGAAC
AAAAGCGGAAAATCATCGGCAACGAGTTTATTTACGTATTTGACGACGAGGCGGCCAAGCTTGAAGGCATTGAATTTTTG
GTGCAAGGCACGCTCTATACCGACATTATCGAAAGCGGCACGGCGACGGCGCAAACGATCAAATCGCATCATAATGTCGG
CGGTTTGCCGGAAGATATGAAATTCGAACTGATCGAACCGCTCAATACGCTGTTTAAAGACGAAGTGCGTGCACTCGGCA
CGCAACTAGGAATCCCAGACGAAATCGTCTGGCGGCAGCCGTTCCCGGGGCCAGGGCTTGGCATCCGTGTTCTTGGAGAA
GTGACGGAAGAAAAATTGGAAATCGTTCGCGAATCAGACGCCATTTTGCGCGAAGAAGTGAAAAAAGCTGGGTTGGACCG
CGAAATTTGGCAATACTTTACCGTCCTTCCCGACATTCGCAGCGTTGGGGTGATGGGGGATGCCCGCACGTACGATTATA
CGGTGGCCATCCGCGCGGTGACCTCGATTGACGGGATGACCGCCGATTGGGCGCGCATCCCGTGGGATGTGCTCGAGCGG
ATTTCAACGCGCATCGTCAATGAGGTGCCGCATGTCAACCGCGTCGTCTACGATATTACAAGCAAGCCTCCGGCAACGAT
CGAGTGGGAATAA

Protein sequence :
MNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTIRAEEIRALNAKGIIFSGGPNSVYDEQAFTCDPAIFELGLPILG
ICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLLFHGLPDEQVVWMSHGDLVTAPPAGFAVDATSPSCPIAAMSDER
RKWYGVQFHPEVRHSVYGNDLLKKFVFEVCGCRGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHRAIG
DQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKDRFLAKLKGVTDPEQKRKIIGNEFIYVFDDEAAKLEGIEFL
VQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFELIEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRVLGE
VTEEKLEIVRESDAILREEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDVLER
ISTRIVNEVPHVNRVVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 0.0 74
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 0.0 74
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 0.0 74
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-137 54