Gene Information

Name : GK2540 (GK2540)
Accession : YP_148393.1
Strain : Geobacillus kaustophilus HTA426
Genome accession: NC_006510
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 2553395 - 2554528 bp
Length : 1134 bp
Strand : -
Note : catalyzes the formation of L-homocysteine from cystathionine

DNA sequence :
ATGAGGCGGAAAACAATGCTCATTCATGGCGGCATTCCGGGGGATCCGCATACTGGAGCGGTGTCGGTCCCGATTTATCA
AGTGAGTACGTATAAGCAAGAAGAAGTTGGAAAGCATAAAGGGTTTGAATACTCGCGCACCGGCAACCCGACGCGCGCGG
CGCTTGAGAAGCTGATCGCTGATCTCGAGGGCGGCGAAGCCGGCTTTGCGTTCGCTTCCGGTATGGCGGCAATTACGGCC
GTCATGATGTTGTTTCAAAGCGGCGACCATCTAGTGCTCACTGACGATGTGTACGGCGGCACGTATCGCGTCATGACGAA
CGTGCTGAATCGGTTCGGGCTTGAGGCGACGTTCGTCGATACGAGCGATGTCGCCAACATCGAGGCGCACATCCGGCCGA
ATACGAAAGCCATCTATATTGAAACGCCGACGAACCCGCTGTTGAAAATCACTGACTTGCAAGCCGCCGCCGCCATTGCC
CGTGCGCATGGGCTGCTATTGATCGTCGATAACACGTTTTCCACTCCGTACTTTCAGACGCCGCTTGAGCTTGGCGCCGA
TATCGTCATCCATAGCGCGACGAAATATTTAGGCGGCCATAGCGACGTCGTCGCTGGGTTGGCGGTTGTCCGCACGCCGG
AGCTTGCCGAGCGGCTCCATTACGTGCAAAATTCAACCGGCGGCGTGCTCGGGCCGCAAGATTCATGGCTATTGATGCGC
GGGATGAAAACGCTCGCCGTGCGGATGGAGGAACATGAAGAAAATGCGCGCCAAATCGCTGTTTTTTTGGCTGAACACAA
GGCGGTCAAGCGCGTCCATTATCCAGGTCTTCCGGATCATCCGAACCACGAGTTGGCGAAAAAGCAAATGCGCGGATTTG
GCGGCATGATTTCGTTTGATGTCGGCAGCTTGGAGCGCGCCGAGAAAGTGCTGTCGCGCGTGCGCTACTTTACGCTTGCC
GAAAGCTTAGGGGCGGTCGAAAGTTTAATTTCGTTGCCAGGGAAAATGACGCACGCCTCGATCCCGAAGGAACGGCGCGA
ACAGCTCGGCATTACCGATGGCCTGATCCGTTTGTCGGTCGGGCTTGAAGATGTCAACGATCTGCTTGACGATTTGGCGA
AGGCGCTTGGCTGA

Protein sequence :
MRRKTMLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIADLEGGEAGFAFASGMAAITA
VMMLFQSGDHLVLTDDVYGGTYRVMTNVLNRFGLEATFVDTSDVANIEAHIRPNTKAIYIETPTNPLLKITDLQAAAAIA
RAHGLLLIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTPELAERLHYVQNSTGGVLGPQDSWLLMR
GMKTLAVRMEEHEENARQIAVFLAEHKAVKRVHYPGLPDHPNHELAKKQMRGFGGMISFDVGSLERAEKVLSRVRYFTLA
ESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSVGLEDVNDLLDDLAKALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-96 57
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-97 57
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 3e-73 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GK2540 YP_148393.1 cystathionine beta-lyase BAC0207 Protein 2e-63 46