Gene Information

Name : TTHA0959 (TTHA0959)
Accession : YP_144225.1
Strain : Thermus thermophilus HB8
Genome accession: NC_006461
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : -
Position : 904708 - 906255 bp
Length : 1548 bp
Strand : +
Note : similar to GB:AAS80941.1 percent identity 100 in 515 aa

DNA sequence :
ATGAGGTACGCGGACCGGGTGGCCGGGATTTCCTGGGAGACGATTGAGGAGGTGCGCCGGCGCCTCAAGGAAAGGCCCGC
CCTCCACTTCATCGCCGGGGAGTTCGTTCCCTCGGAAAGCGGGGAGACCTTCCCCTCCCTAGACCCCGCCACGAACGAGG
TCTTGGGCGTGGCGGCGAGGGGCGGGGAGAGGGAGGTGGACCGGGCGGCCAAGGCGGCCCACGAGGCCTTCCAAAGGTGG
AGCCGCACCAAGGCCAAGGAGAGGAAGCGCTACCTCTTGAGGATCGCCGAGCTCATAGAGAAGCACGCGGACGAGCTCGC
CGTGATGGAGTGCCTGGACGCGGGGCAGGTCTTAAGGATCGTCCGGGCCCAGGTGGCCCGGGCGGCGGAGAACTTCGCCT
TCTACGCCGAGTACGCCGAGCACGCCATGGAGGACCGGACCTTCCCCGTGGACCGGGACTGGCTCTACTACACCGTGCGG
GTTCCCGCGGGGCCCGTGGGGATCATCACCCCCTGGAACGCCCCCCTGATGCTCTCCACTTGGCGCATCGCCCCCGCCTT
GGCCTTTGGGAACACCGTGGTCCTGAAGCCCGCGGAGTGGAGCCCCTTCACCGCCACGAAGCTCGCGGAGATCCTAAAGG
AGGCGGACCTCCCCCCGGGGGTCTTCAACCTGGTCCAGGGCTTTGGCGAGGAGGCGGGGGCGGCCTTGGTGGCCCACCCC
CTCGTCCCCCTCCTCACCCTCACCGGGGAGACGGAGACGGGGAAGATCGTCATGCGCAACGCCGCAGACCACCTCAAGCG
CCTCTCCCCGGAGCTCGGCGGCAAAAGCCCCGCCCTGGTCTTCGCCGACGCCGACTTGGAGAGGGCCCTGGACGCCGTGG
TCTTCCAGATCTTCTCCTTCAACGGGGAAAGGTGCACGGCAAGCTCCAGGCTCCTCGTGGAGGAGAAGATCTTTGAGGAC
TTCGTGGGGAAGGTGGTGGAAAGGGCCAGGGCCATCCGGGTGGGCCACCCCCTGGACCCCGAGACCGAGGTGGGGCCCCT
GATCCACCCCGAGCACCTCCAAAGGGTCCTGGGCTACGTGGAGGCGGGGAAGCGGGAAGGGGCGAGGCTCCTCGTGGGCG
GGGAGCGGGCCAAGACCTCCTTCCGGGGGGAGGACCTCTCCCGGGGGAACTACCTCCTTCCCACGGTTTTCGTGGGGGAG
AACCACATGAAAATCGCCCAGGAGGAGATCTTCGGGCCCGTCCTCGTGGCCATCCCCTTCAAGGACGAGGAGGAGGCCCT
AAGGAAGGCGAACGACACCAAGTACGGCCTTGCCGCCTACGTCTTCACCCGGGATCTGGAAAGGGCCCACAGGCTCGCCT
TGGAGCTCGAGGCGGGGATGGTCTACTTGAACAGCCACAACGTCCGCCACCTGCCCACGCCCTTCGGCGGGGTGAAGGGA
AGCGGGGACCGGAGGGAGGGCGGCACCTATGCCCTGGACTTCTACACCGACCTCAAGACCATCGCCCTTCCCCTCCGCCC
CCCGCACGTGCCCAAGTTCGGGAAGTAA

Protein sequence :
MRYADRVAGISWETIEEVRRRLKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRW
SRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVR
VPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHP
LVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFED
FVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVGE
NHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKG
SGDRREGGTYALDFYTDLKTIALPLRPPHVPKFGK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 5e-89 47
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 2e-65 44
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-62 42
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 5e-64 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 5e-64 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 5e-64 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-63 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TTHA0959 YP_144225.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 1e-62 42