Gene Information

Name : ddl (TTHA1587)
Accession : YP_144853.1
Strain : Thermus thermophilus HB8
Genome accession: NC_006461
Putative virulence/resistance : Resistance
Product : D-alanyl-alanine synthetase A
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : -
Position : 1510700 - 1511659 bp
Length : 960 bp
Strand : -
Note : D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli

DNA sequence :
ATGAGGGTTCTTCTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTTTCCGCGGAAGGGGTTCTGCGCCA
CATCCCCTTCCCCACGGACCTCGCCGTGATCGCCCAGGACGGGCGCTGGCTTCTGGGGGAAAAGGCCTTGACCGCCTTGG
AGGCCAAGGCGGCCCCCGAGGGGGAGCACCCCTTCCCCCCGCCCCTCTCCTGGGAGCGGTACGATGTGGTCTTTCCCTTG
CTCCACGGCCGCTTCGGCGAGGACGGGACGGTCCAGGGGTTTCTGGAGCTTTTGGGCAAGCCCTACGTGGGGGCGGGGGT
GGCGGCGAGCGCCCTCTGCATGGACAAGGACCTGAGCAAGCGGGTCCTCGCCCAGGCGGGGGTGCCCGTGGTCCCCTGGG
TGGCGGTGCGGAAGGGCGAGCCCCCCGTGGTGCCCTTTGACCCCCCCTTCTTCGTCAAGCCGGCCAACACCGGCTCCAGC
GTGGGGATAAGCCGGGTGGAGCGCTTCCAGGACCTGGAGGCCGCCCTGGCCTTGGCCTTCCGCTACGACGAGAAAGCGGT
GGTGGAGAAGGCCCTCTCCCCGGTGCGGGAGCTGGAGGTGGGGGTCTTGGGCAACGTCTTCGGGGAGGCGAGCCCCGTGG
GGGAGGTGCGCTACGAGGCGCCCTTCTACGACTACGAGACCAAGTACACCCCGGGCCGGGCCGAGCTCCTCATCCCCGCG
CCCTTGGACCCCGGCACCCAGGAGACCGTTCAGGAGCTCGCCCTCAAGGCCTACAAGGTGCTCGGGGTGCGGGGGATGGC
CCGGGTGGACTTCTTCCTCGCGGAGGGGGAGCTTTACCTGAACGAGCTCAACACCATCCCCGGCTTCACCCCCACCAGCA
TGTACCCCCGCCTCTTTGAGGCGGGGGGGGTGGCCTACCCGGAGCTTCTCAGGCGCCTGGTGGAGCTCGCCCTCACCTAA

Protein sequence :
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPEGEHPFPPPLSWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 2e-34 41
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 4e-34 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ddl YP_144853.1 D-alanyl-alanine synthetase A NC_005054.2598280.p0 Protein 1e-33 42
ddl YP_144853.1 D-alanyl-alanine synthetase A NC_014475.1.orf3.gen Protein 1e-33 42
ddl YP_144853.1 D-alanyl-alanine synthetase A AY489045.gene.p01 Protein 9e-36 42
ddl YP_144853.1 D-alanyl-alanine synthetase A AF277571.gene.p01 Protein 1e-36 42
ddl YP_144853.1 D-alanyl-alanine synthetase A AY145441.gene.p01 Protein 6e-34 41
ddl YP_144853.1 D-alanyl-alanine synthetase A AF310956.2.orf5.gene Protein 2e-33 41
ddl YP_144853.1 D-alanyl-alanine synthetase A U00456.gene.p01 Protein 2e-34 41
ddl YP_144853.1 D-alanyl-alanine synthetase A U35369.1.gene6.p01 Protein 2e-34 41
ddl YP_144853.1 D-alanyl-alanine synthetase A AE016830.1.gene2250. Protein 2e-34 41
ddl YP_144853.1 D-alanyl-alanine synthetase A AF130997.1.orf4.gene Protein 2e-36 41