Gene Information

Name : leuS (str0220)
Accession : YP_140649.1
Strain : Streptococcus thermophilus CNRZ1066
Genome accession: NC_006449
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 223191 - 225692 bp
Length : 2502 bp
Strand : +
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGAGTTTTTACAATCATAAAGAAATCGAGCCTAAGTGGCAAAAATACTGGGCTGACCATCATACATTTAAGACAGGAAC
AGATGCTTCAAAACCTAAGTTTTATGCGCTTGACATGTTCCCTTACCCATCTGGAGCGGGTCTTCACGTAGGACACCCAG
AAGGCTACACAGCGACAGATATCCTTAGCCGTTTCAAGCGTGCCCAAGGCTATAACGTCCTTCACCCAATGGGATGGGAT
GCTTTTGGTTTGCCTGCTGAGCAATATGCTATGGATACTGGTAATGATCCAGCTGACTTTACAGCGGAAAATATTGCCAA
CTTCAAACGTCAAATCAACGCGCTTGGCTTCTCTTACGACTGGGATCGTGAAATCAACACAACAGATCCAAACTACTATA
AGTGGACGCAGTGGATTTTCACCAAGCTTTACGAAAAAGGTTTGGCTTATGAGGCGGAAGTACCAGTAAACTGGGTTGAG
GAACTAGGAACAGCTATCGCCAATGAAGAAGTCCTTCCGGACGGAACTTCTGAGCGTGGTGGCTATCCAGTTGTCCGTAA
ACCAATGCGCCAATGGATGCTTAAAATCACTGCTTATGCAGAGCGATTGCTCAATGACTTGGATGAGTTGGATTGGCCAG
AGTCTATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCCAATGTCACCTTCAAAGTGAAAGGTACTGAC
AAGGAATTCACCGTCTTTACGACACGTCCGGATACCCTTTTCGGTGCGACTTTCACTGTTTTGGCGCCTGAGCATGACTT
AGTAGATGCTATCACAAGTCCTGAACAAGCTGAGGCTGTAGCTAACTACAAACACCAAGCTAGCCTTAAATCAGACTTGG
CTCGTACCGACCTTGCCAAGGAAAAAACAGGGGTTTGGACTGGAGCTTATGCTATAAACCCTGTTAACGGTAGAGAAATT
CCAATCTGGATTGCGGACTACGTTCTCGCTAGCTACGGAACAGGTGCAGTTATGGCCGTACCTGCTCACGATGAGCGTGA
CTGGGAATTTGCTAAACAGTTTGGTCTTCCAATCGTAGAAGTACTTGAAGGTGGCAACGTTGAAGAAGCAGCTTACACAG
AAGACGGTCCTCATGTCAACTCTGACTTCTTGAACGGGCTTAACAAAGAAGAAGCTATTGCTAAAATTGTAGCTTGGTTG
GAAGAAAAAGGCTTTGGTCAAGAAAAAATCACTTACCGTCTCCGCGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA
ACCAATCCCAATCATTCATTGGGAAGATGGCACTTCAACAGCCGTTCCAGAAAGCGAATTGCCACTTGTCTTGCCAGTAA
CCAAGGACATCCGTCCTTCAGGTACTGGTGAAAGTCCATTGGCTAACTTGACAGACTGGCTTGAAGTGACTCGTGAAGAT
GGGGTCAAAGGTCGTCGTGAAACCAACACCATGCCACAATGGGCAGGTTCAAGCTGGTACTACCTTCGCTATATCGACCC
ACATAACACAGAAAAATTGGCAGATGAGGACCTCCTCAAACAATGGTTGCCAGTCGATATCTACGTGGGTGGTGCAGAAC
ACGCCGTTCTTCACTTGCTTTACGCTCGTTTCTGGCACAAATTCCTCTATGACCTCGGTGTCGTTCCAACTAAAGAACCA
TTCCAAAAACTCTTTAACCAAGGAATGATCTTGGGAACAAGCTACCGTGACCACCGTGGTGCTCTTGTGGCGACTGACAA
GGTTGAAAAACGTGATGGTTCCTTCTTCCATGTGGAAACAGGAGAAGAGTTGGAGCAAGCACCAGCCAAGATGTCTAAAT
CCCTCAAGAACGTGGTTAACCCAGACGATGTGGTGGAACAATATGGTGCTGATACCCTTCGTGTCTATGAAATGTTCATG
GGACCACTCGATGCTTCTATCGCTTGGTCAGAAGAAGGCTTGGAGGGAAGTCGTAAATTCCTTGATCGTGTTTACCGTTT
GATTACAAGTAAAGAAATCGTTGCGGAAAATAATGGTGGTCTTGACAAAGTTTATAACGAAACCGTTAAATCCGTCACTG
AGCAAATTGAGTTGATGAAATTCAACACAGCCATTGCTCAACTCATGGTCTTTGTTAACGCGGCTAACAAGGAAGACAAA
CTCTATGTGGATTATGCCAAAGGCTTTGTCCAATTGATTGCCCCATTTGCGCCTCACTTGGCAGAAGAACTCTGGCAAAC
TCTTACAGCAACAGGTGAGTCAATCTCTTATGTGGCTTGGCCAACTTGGGACGAAAGCAAATTAGTTGAAGACGAAATCG
AAATCGTCGTCCAAATCAAAGGAAAAGTCCGTGCTAAACTCATGGTCGCTAAAGACCTTTCACGCGAAGAATTGCAAGAA
GTGGCTCTGGCTGACGAAAAAGTCAAAGCAGAGATTGATGGCAAGGAAATCGTGAAAGTAATTGCGGTACCGAACAAGCT
TGTGAACATTGTTGTGAAATAA

Protein sequence :
MSFYNHKEIEPKWQKYWADHHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGYNVLHPMGWD
AFGLPAEQYAMDTGNDPADFTAENIANFKRQINALGFSYDWDREINTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWPESIKDMQRNWIGKSTGANVTFKVKGTD
KEFTVFTTRPDTLFGATFTVLAPEHDLVDAITSPEQAEAVANYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGREI
PIWIADYVLASYGTGAVMAVPAHDERDWEFAKQFGLPIVEVLEGGNVEEAAYTEDGPHVNSDFLNGLNKEEAIAKIVAWL
EEKGFGQEKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTRED
GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEP
FQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM
GPLDASIAWSEEGLEGSRKFLDRVYRLITSKEIVAENNGGLDKVYNETVKSVTEQIELMKFNTAIAQLMVFVNAANKEDK
LYVDYAKGFVQLIAPFAPHLAEELWQTLTATGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREELQE
VALADEKVKAEIDGKEIVKVIAVPNKLVNIVVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 0.0 91