Gene Information

Name : pyk (stu1196)
Accession : YP_139647.2
Strain : Streptococcus thermophilus LMG 18311
Genome accession: NC_006448
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1050148 - 1051650 bp
Length : 1503 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGAATAAACGCGTAAAAATAGTTGCTACACTTGGTCCTGCGGTTGAAATCCGTGGTGGCAAGAAATTTGGTGAAGATGG
TTACTGGAGTGAAAAACTTGACCCTGATGCATCTGCTAAAAACATTGCTCAATTGATCGAGGAAGGTGCTAACGTTTTCC
GTTTCAACTTCTCACATGGTAACCACGCTGAGCAAGGTGAACGTATGGATGTCGTACGTATGGCTGAATCTATTGCTGGT
CAAAAAGTAGGTTTCCTTCTTGACACTAAGGGACCTGAAATCCGTACTGAATTGTTTGAAGGTGATGCTAAAGAGTATGC
ATACAAAACTGGTGAACAAATCCGTATTGCTACTAAACAAGGTCTCAAATCAACTCGCGACGTTATTGCTTTGAACGTTG
CTGGTGCACTTGACATTTTCGACGATGTAGAAGTTGGTAAACAAGTTCTTGTGGATGATGGTAAACTTGGTCTTCGTGTT
GTAGACAAGGATGCTGAAAAACGTGAATTCATCGTTGAAGTTGAAAATGATGGTATTATTGCTAAACAAAAAGGTGTAAA
CATCCCTTACACTAAAATTCCTTTCCCAGCACTTGCTGAACGTGATAATGCTGATATTCGTTTTGGTCTCGAACAAGGTA
TTAACTTTATCGCAATCTCATTTGTACGTACTGCGAAAGACGTACAAGAAGTACGTGCTATCTGTGAAGAAACTGGAAAC
GGCCACGTTAAATTGTTGGCTAAAATCGAAAACCAACAAGGTATCGATAATATCGATGAAATCATTGAAGCTGCTGATGG
TATCATGATCGCTCGTGGTGACATGGGTATCGAAGTACCATTCGAAATGGTTCCAGTTTACCAAAAAATGATTATCACTA
AAGTAAATGCTGCTGGTAAAATTGTTGTTACAGCTACAAACATGCTTGAAACAATGACAGAAAAACCACGTGCAACTCGT
TCTGAAGTATCTGACGTGTTTAACGCAGTTATCGATGGTACTGATGCGACAATGCTTTCTGGTGAGTCTGCAAATGGTAA
ATATCCAGTTGAATCAGTTCGTACAATGGCTACAATTAATAAAAACGCTCAAACTCTTCTTAAAGAGTATGGTCGTCTTA
ATTCATCAACATTTGATCGCTCAAGTAAAACTGAAGTTGTTGCATCTGCAGTTAAAGATGCTACTAACTCAATGAATATC
AAACTTATTGTTGCACTTACTGAATCTGGTAACACAGCTCGTTTGATTTCTAAATACCGTCCAGAAGCTGACATCTTGGC
AATAACATTCGATGAACTTACTCAAAAATCATTGATGCTTAACTGGGGTGTTATTCCAGTTGTTACTGAAACACCTTCAT
CTACTGATGATATGTTTGAAGTTGCTGAGCGTGTTGCTCTTGAATCAGGTCTTGTAGAATCAGGTGATAACATTGTTATT
GTTGCTGGTGTTCCAGTTGGTTCTGGTAATACAAATACTATGCGTATCCGCACAGTTAAATAA

Protein sequence :
MNKRVKIVATLGPAVEIRGGKKFGEDGYWSEKLDPDASAKNIAQLIEEGANVFRFNFSHGNHAEQGERMDVVRMAESIAG
QKVGFLLDTKGPEIRTELFEGDAKEYAYKTGEQIRIATKQGLKSTRDVIALNVAGALDIFDDVEVGKQVLVDDGKLGLRV
VDKDAEKREFIVEVENDGIIAKQKGVNIPYTKIPFPALAERDNADIRFGLEQGINFIAISFVRTAKDVQEVRAICEETGN
GHVKLLAKIENQQGIDNIDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKIVVTATNMLETMTEKPRATR
SEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATINKNAQTLLKEYGRLNSSTFDRSSKTEVVASAVKDATNSMNI
KLIVALTESGNTARLISKYRPEADILAITFDELTQKSLMLNWGVIPVVTETPSSTDDMFEVAERVALESGLVESGDNIVI
VAGVPVGSGNTNTMRIRTVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-73 43
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-73 43
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-73 43
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 8e-74 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_139647.2 pyruvate kinase VFG0479 Protein 5e-74 43