Gene Information

Name : guaA (PBPRA0781)
Accession : YP_128996.1
Strain :
Genome accession: NC_006370
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 864532 - 866115 bp
Length : 1584 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTACATCTACTAATATTCATGACCAGCGTATCCTTATTCTGGATTTTGGTTCTCAATATACTCAGCTAATCGCACG
TCGTATCCGTGAAATCGGTGTTTATTGTGAGCTTTGGAGCTGGGACGTTGATGAAGCCGATATTCGTGACTTCAACCCGA
ACGGTATCATCCTTTCTGGTGGGCCGGAGAGCGTAACCGGAGATGAATCACCTCGCGCACCACAATATGTGTTTGAAGCG
GGTGTACCTGTATTTGGTGTGTGTTACGGCATGCAAACCATGGCCGAGCAGCTTGGCGGTAAAGTTGCCGGCTCTTCAAT
GCGTGAATTTGGTTACGCACAAGTCGAAATTGTTGAACCAACATCATTCTTTAAAAATATTGAAGATGCAGTAGCCGAAG
ATGGTAATGGGTTGCTGGATGTATGGATGAGCCACGGTGATAAAGTGGTCGAAATCCCGTCTGATTTTGTTAAGGTTGCC
CAAACTGATACTTGCCCGTTTGCGGCAATTGCCAACGAAGAGAAGCATTTCTACGGTGTGCAGTTCCACCCGGAAGTGAC
CCATACCCGCCAGGGCATGCGTATTATCGAGAACTTTGTTCTTAATATCTGTGGCTGTGAGAACCTTTGGACATCAGCAA
ACATCATAGAAGACGCCATTGCTAACATCAAAGAGCAAGTGGGTGATGATGAAGTTATCTTAGGCTTATCTGGCGGTGTA
GATTCATCTGTTGTGGCTATGCTGCTTCACCGTGCTATTGGTGACAAACTAACCTGTGTATTCGTTGATAACGGTTTGCT
TCGTTTAAACGAGGGTGAGCAAGTGATGGATATGTTCGGTGACCATTTTGGTTTGAACATTGTGCATGTTAAAGCTGAAG
ATCGTTTCTTAAACGCACTGGCTGGTGAGAACGATCCTGAAGCGAAGCGTAAGATTATCGGTCACGCCTTTATTGATGTA
TTCGATGAAGAATCGAAGAAGCTGAAAAATGCTAAGTGGTTGGCTCAAGGTACTATCTACCCTGATGTCATCGAGTCTGC
TGCCTCTAAAAATGGTAAAGCGCATGTGATTAAATCTCACCATAACGTTGGCGGTCTGCCAGATGATATGGAAATGGGAT
TAGTTGAGCCTCTACGTGAATTGTTTAAAGATGAAGTACGTAAGATTGGTCTAGAACTAGGTCTTCCGTACAATATGCTT
TACCGCCACCCGTTCCCTGGACCAGGTCTAGGTGTACGTGTACTAGGTGAAGTAAAGAAAGAGTACTGTGACTTACTACG
TCGTGCAGATGCTATCTTCATTGAAGAGCTACACAGTGCAGATCTTTACAACAAAGTGTCTCAAGCATTTACGGTATTCC
TACCAGTACGCTCGGTTGGCGTAATGGGTGATGGTCGTAAATATGATTGGGTTGTATCACTGCGTGCTGTTGAAACGATT
GATTTCATGACTGCGCATTGGGCACACCTTCCATACGATTTCTTAGGTAAGGTTTCTAACCGTATCATTAACGAAGTTGA
TGGCATTTCACGTGTTGTTTACGATATTTCTGGTAAGCCACCAGCAACTATCGAGTGGGAATAA

Protein sequence :
MTTSTNIHDQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEADIRDFNPNGIILSGGPESVTGDESPRAPQYVFEA
GVPVFGVCYGMQTMAEQLGGKVAGSSMREFGYAQVEIVEPTSFFKNIEDAVAEDGNGLLDVWMSHGDKVVEIPSDFVKVA
QTDTCPFAAIANEEKHFYGVQFHPEVTHTRQGMRIIENFVLNICGCENLWTSANIIEDAIANIKEQVGDDEVILGLSGGV
DSSVVAMLLHRAIGDKLTCVFVDNGLLRLNEGEQVMDMFGDHFGLNIVHVKAEDRFLNALAGENDPEAKRKIIGHAFIDV
FDEESKKLKNAKWLAQGTIYPDVIESAASKNGKAHVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYNML
YRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHSADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETI
DFMTAHWAHLPYDFLGKVSNRIINEVDGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-128 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-128 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-128 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-113 49