Gene Information

Name : thyA (lpl2781)
Accession : YP_128108.1
Strain : Legionella pneumophila Lens
Genome accession: NC_006369
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3178743 - 3179537 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAACATATTTGCAATTGTTAGAGCATATTTTACAACATGGGGTAGAAAAATCGGATAGAACGGGCACTGGAACATT
ATCTGTATTTGGGTATCAAATGCGTTTTGATTTGGCCAAGGGATTCCCGCTTGTTACCACTAAAAAACTACATACGAGAA
GTATTGTTCATGAATTACTATGGTTTTTGCGTGGTGATACCAATATTTCTTATCTTAAGGAAAATGGGGTAACTATTTGG
GATGAATGGGCAGATAATAATGGTGATTTGGGGCCTGTCTATGGAAAGCAATGGAGAAGTTGGCCCACTGCTGATGGAGG
CACCATTGATCAATTAAGTGATGTAGTGCAACAAATAAAGAGCAACCCTGACTCTCGTCGCTTGATTGTAAGCGCCTGGA
ATGTGGGTGAATTGGATAAAATGGCTTTAATGCCTTGTCATGCCTTGTTTCAGTTTTATGTTGCAAACAACAAGTTATCC
TGTCAATTGTATCAACGCTCAGCCGATGTATTTTTAGGAGTTCCTTTCAATATCGCTTCTTATTCGTTGCTTACTCATAT
GGTCGCCCAACAATGTAATTTGGATGTGGCCGAGTTCATATGGACCGGGGGAGATTGTCATTTGTATCTTAATCATTTGG
AGCAAGCGCAAACTCAATTAACAAGAGAACCTTTGCCATTGCCCTCCTTAGCTATTAAGAGAAAACCGGCTTCTTTATTT
GATTATGCTTACGAGGATTTCGAATTTGTGAACTATCAATCACATCCTGCAATTAAAGCGCCTATCGCCGTTTAA

Protein sequence :
MKTYLQLLEHILQHGVEKSDRTGTGTLSVFGYQMRFDLAKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIW
DEWADNNGDLGPVYGKQWRSWPTADGGTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLS
CQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQTQLTREPLPLPSLAIKRKPASLF
DYAYEDFEFVNYQSHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 5e-85 65