Gene Information

Name : murD (lpl2539)
Accession : YP_127868.1
Strain : Legionella pneumophila Lens
Genome accession: NC_006369
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 2896678 - 2898021 bp
Length : 1344 bp
Strand : -
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGAATCATTCCTTATATTTGGTAGCAGGGCTGGGTAAGACGGGACTCTCTATAGCAAGATACCTGAAGAGAAATAATAA
ATCGTTTGTTGTTTTTGATACACGTAAAGAGGCTCCTGGATTAGCTGAATTCCAAAATGAATTTCCCGATGTGCCAATTT
ACCTGCAACAGACCCCTGATGAAGTAATCAGCCAGGTGACGGATGTTATCACTAGCCCTGGTTTGGCACTGGATACGCCT
GTTTTAGAGAGCGCGCGTCAAGCGGGCGCATTAATTTATGGAGACATAGAATGCCTGGCCAGAGAGATTAGCGCCCCTGT
CATTGCTATAACGGGAACTAATGGTAAATCCACTGTAACGACTTTGGTGGGAGAAATGGCTAAGGCGGCCGGGTTTCGTG
TAGCTGTAGCCGGAAATATCGGCACTCCTGTCTTAGATATGTTGGATGATGAACATCACTACGATTTGTGGGTATTGGAG
TTATCCAGTTTTCAACTGGATTTAACTTATTCTTTGTCGCCAGTGGTTGCGACGATTCTTAATGTAACGCCTGATCATTT
GGACAGGCATCACACTATGGAAGCCTATACGCAAGCAAAACAAAGGATTTATCGTGGTGCCAAGGCTGTTTTATTTAATC
GTGAAGACGTCTACACTGTTCCTCACCAATCCTGTCAAGCAGATATAAAATGCATCTCTTTTGGCAAAGACGCGCCTTCA
ATGGGAAATTGGGGGCTGATTGAACAAGAGAATACTATTTATTTGGCGAAAGGAATGGAGCGTCTTTTGCCAGTGGAATC
GATTTTAATAAAAGGGGTGCATAATTGGATGAATGCGCTTGCTGCTTGTGCTTTAGCCGAAGCAGCGGGAATTTCTATGC
AACACATTCTTAATGTTTTAAAAACCTTCCCTGGACTGCCACATCGATGTCAGTGGGTAAGAGAAGTGGATGGAGTAGGT
TGGATTAATGATTCGAAAGGAACAAATATTGGTGCTACAATCTCTGCTATTAATGGAATAGGAGGTTCTATGCAAGGGAA
AATTGTTCTTATTGCGGGTGGACAGGGAAAAGGGGCGGATTTCCAAGAATTAGCCCAGCCAGTTTCAGAATTTGTTCGTT
CCATTGTTTTGATTGGTGAAGATGCTGACAAGATTGAATCGGCTTTAGCCAAAGTAGTTCCTGTCGTGCGTGCTTCTTCT
CTGGAGGGCGCTGTGACTATTGCCAAGACATGTGCGAAACCTGGTGATGTCGTTTTATTATCTCCAGCTTGCGCCAGTTT
GGATATGTTCCGTGATTTTAATCATAGGGGCGATGTGTTTACATCTTCAGTGCGCGGATTGTGA

Protein sequence :
MNHSLYLVAGLGKTGLSIARYLKRNNKSFVVFDTRKEAPGLAEFQNEFPDVPIYLQQTPDEVISQVTDVITSPGLALDTP
VLESARQAGALIYGDIECLAREISAPVIAITGTNGKSTVTTLVGEMAKAAGFRVAVAGNIGTPVLDMLDDEHHYDLWVLE
LSSFQLDLTYSLSPVVATILNVTPDHLDRHHTMEAYTQAKQRIYRGAKAVLFNREDVYTVPHQSCQADIKCISFGKDAPS
MGNWGLIEQENTIYLAKGMERLLPVESILIKGVHNWMNALAACALAEAAGISMQHILNVLKTFPGLPHRCQWVREVDGVG
WINDSKGTNIGATISAINGIGGSMQGKIVLIAGGQGKGADFQELAQPVSEFVRSIVLIGEDADKIESALAKVVPVVRASS
LEGAVTIAKTCAKPGDVVLLSPACASLDMFRDFNHRGDVFTSSVRGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 5e-79 45
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 5e-79 45