Gene Information

Name : cadA2 (lpp2370)
Accession : YP_124680.1
Strain : Legionella pneumophila Paris
Genome accession: NC_006368
Putative virulence/resistance : Resistance
Product : hypothetical protein
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 2717023 - 2719158 bp
Length : 2136 bp
Strand : -
Note : similar to cation transport ATPase

DNA sequence :
ATGACAGTACCTTTAAATGAAATCAAATTTTTTGTTGCAGGACTTGATTGTCCAGCAGAAGAGCAGCTTATCAGAAAGCA
GTTTCAGGATATTCCTGAAGTGGAGCAGTTGGATTTTAATTTTATTGCTGAAGAAGTTACTATTCATCATCGGTTGGTTT
CAAGTGAAGAATTGCAAAAACGCATTGAGGCGTTGGGAATGAGTGTTCGAACGCTGGAAAGCACTTTACCTATACCACAA
AGAAAACAATTATCGTTGGATTTTTCCTGGAAAATTATTGGACTAGCAGGTTTTCTTGCCCTATTTTCTGAGCTGGCAGC
TTATTTTTTAGCTACGGAACAATCCATTTGGACTATTCTTCCAGCTTTGTTGGCTATTGGTCTTAGTGGGCCTTCTACCT
TTAAAAAAGGGTGGCTTGCCTTAGGGACTAAAACAATGAATATCAATAGCTTGATGTTCATTGCGATAGCAGGGGCTGTT
CTTATTGGAGAGTGGCCTGAAGCGGCAATGGTGACTGTATTATTTGCATTGGCCGAACGTATCGAGCGCTACTCCTTAGA
TAAAGCACGTCTTGCGATTCGAAGCTTAATGCAAATTGCCCCTGAGGTGGCTTCAGTGAAACAGGACGATGGTCAATGGC
AAACCTTGGCCATTGAAAAAGTGGTGCCTGGTGCTATTTTTAGAGTAAAACCTGGAGAGCGTATTCCCCTGGATGGCGTG
GTTATTTCAGGTCAGAGCACGGTCAATCAAGCGCCGATTACTGGTGAATCAATGCCAATAACAAAAAAAGTGGGTGATTT
GGTTTTTGCAGGAACATTAAATGAGCACGGCGCGTTTGAAGTGCAGGTCAGTAAAGTGTCAGGCGATACATTGCTTGCTA
AAATTGGTAAAGCGATAGAGCAAGCGCAAGCGGATCGAGCTCCAACACAACGATTTGTTGATCAGTTTTCTAAATATTAT
ACTCCAATTATGGTATTGATGGCTTTTTTTGTTGCATTAATTCCACCTTTAGCATTTGGTTATCCTTTTTATGATTCTCT
TTATAAGTCACTGACTTTATTAGTTATTGCTTGCCCTTGCGCTTTAGTGATTTCAACACCTGTGACTGTTGTAAGTGGTC
TTGCAGCGGCAGCAAAACAAGGGCTTCTTATTAAAGGAGGAAGCTACTTAGAGGTTGGTCATCGACTGAGGTTAATTGCT
TTAGATAAGACAGGTACTTTAACGGAAGGAAAGCCAGTTGTAACTGACTTCATAGCTTGGGATGAAAATCGAACTAAGGA
GAGTTTGTTATTGTTAGCTGCAAGCCTTGATAGTCACTCAGAGCATCCAGTCGCTAATGCCTTAGTACAGTACTGGCAAC
AGGAACAACCTCAAAACGCTTTACTTGAAATTGAGCAATTTTCAGCACTTCCTGGACGAGGAGTAAAAGGATTGGTGGGT
CAAGAACTCTATTTTGTAGGCAATCATCAGTTAGCTGAAGACAATCAGGTATGCAATCATTTTGTCGAACAAGAGCTGAA
GCGCTTGGAGGAAGAAGGTAAAACGACCGTAATATTAAGTAATGCTACGACGGTTTTGGCTATTTTTGCAGTAGCTGATA
CGTTACGTGTTACAAGCCAACAGGCGATTGCACAACTCCATGAACGGGGCATAAAAACCGCGATGTTAACGGGAGACAAT
GCGGTAACGGCTCAGGCTATTGCTAAAAAAGTAGGTATTGATGAAGTAAATGCAAATATATTGCCTGCGGAAAAACTGCA
AGCGATTAATCGTCTTTTAGAACACTATCATAGCGTTGGGATGGTAGGAGATGGAATTAATGATGCCCCTGCATTGGCAA
AAGCTACCGTGAGTTTTGCGATGGGGAAAGGAACAGATACTGCCTTAGAAACTGCTGACGTTGCCCTAATGAATGACAAT
CTAGCAAGACTTCCCTTTTATGTTGATTTAAGTCGTAAGACGGCACGTACTCTTTATCAAAACATCAGTTTATCTATTGC
GATTAAAGGCATTTTCTTTATTTTAGCTCTTGTAGGGTATGCAACGTTATGGATGGCAGTTTTTGCAGACATGGGAGCGA
GTTTAATCGTAGTGGCTAATGGTTTGCGATTGTTGTATATGTCTCCAGATGATTAA

Protein sequence :
MTVPLNEIKFFVAGLDCPAEEQLIRKQFQDIPEVEQLDFNFIAEEVTIHHRLVSSEELQKRIEALGMSVRTLESTLPIPQ
RKQLSLDFSWKIIGLAGFLALFSELAAYFLATEQSIWTILPALLAIGLSGPSTFKKGWLALGTKTMNINSLMFIAIAGAV
LIGEWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIAPEVASVKQDDGQWQTLAIEKVVPGAIFRVKPGERIPLDGV
VISGQSTVNQAPITGESMPITKKVGDLVFAGTLNEHGAFEVQVSKVSGDTLLAKIGKAIEQAQADRAPTQRFVDQFSKYY
TPIMVLMAFFVALIPPLAFGYPFYDSLYKSLTLLVIACPCALVISTPVTVVSGLAAAAKQGLLIKGGSYLEVGHRLRLIA
LDKTGTLTEGKPVVTDFIAWDENRTKESLLLLAASLDSHSEHPVANALVQYWQQEQPQNALLEIEQFSALPGRGVKGLVG
QELYFVGNHQLAEDNQVCNHFVEQELKRLEEEGKTTVILSNATTVLAIFAVADTLRVTSQQAIAQLHERGIKTAMLTGDN
AVTAQAIAKKVGIDEVNANILPAEKLQAINRLLEHYHSVGMVGDGINDAPALAKATVSFAMGKGTDTALETADVALMNDN
LARLPFYVDLSRKTARTLYQNISLSIAIKGIFFILALVGYATLWMAVFADMGASLIVVANGLRLLYMSPDD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 2e-157 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 9e-123 43
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 5e-121 42
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 5e-121 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA2 YP_124680.1 hypothetical protein BAC0298 Protein 1e-155 52