Gene Information

Name : metB (nfa48270)
Accession : YP_121043.1
Strain : Nocardia farcinica IFM 10152
Genome accession: NC_006361
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 5041407 - 5042552 bp
Length : 1146 bp
Strand : -
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAGCGAGCTGGGATTCTCCACCAGGGCCGTGCACGCCGGATTCGATCCCGATCCCCAGACCGGCGCGGTGAACGTGCC
GATCTACGCGAGCTCGACGTTCGCCCAGGACGGTGTCGGCGGCCTGCGCGGCGGATTCGAGTACGCCCGGACCGGCAACC
CGACCCGCAGCGCCCTGGAGGCCAACCTGGCCGCCCTCGAATCGGGCGCGCACGGCCGGGCCTTCGCCTCCGGCATGGCC
GCCACCGACTGCGTGCTGCGCGCCACCCTGCGCCCCGGCGACCACATCGTCATCCCCGACGACGCCTACGGCGGCACCTT
CCGGCTGATCGACAAGGTCTTCAGCCAGTGGGGCATCGAGCACACCCCGGCCCACGTCTTCGACACCGACGCAATGCGCG
CGGCCATCCGCCCCAACACCAAGCTGGTGTGGGTGGAGACGCCGACCAATCCGCTGCTGAGCATCGGCGACATCCCGGCC
CTCGCCGAGATCGCGCACGCCGCGGGCGCGAAGCTGGTGGTGGACAACACCTTCGCGACCCCGTATCTGCAGCAGCCGCT
GGTGCTCGGCGCCGACGTGGTCGTGCACTCGACCACCAAGTACCTGGGCGGGCACTCCGACGTGGTGGGCGGCGCGCTGA
TCACCAACGATCCGGAGCTGGACGCGGCCTTCGGCTTCCTGCAGAACGGCGCGGGCGCGGTGCCCGGCCCGTTCGACGCC
TACCTCACCATGCGCGGCACCAAGACACTGGCCGTGCGGATGGAGCGGCACTGCGACAACGCCGAGGCCATCGCCGGTTT
CCTGGCGAAGCACCCGGCGGTATCCACGGTGATCTACCCGGGCCTGCCGGAGCATCCCGGCCACGCCGTCGCCGACAAGC
AGATGCGTCGTTTCGGCGGCATGATCTCGGTCCGGTTGCACGGCGGCCGGGACGCGGCACTGGACTTCTGCTCGCGGACG
AAGATCTTCACCCTCGCCGAGTCGCTGGGCGGGGTCGAGTCGCTGATCGAACACCCCGGCGCGATGACGCACGCCTCCAC
CGCGGGCTCCCAGCTCGAAGTGCCCGCGGACCTGGTGCGGCTGTCGGTCGGCATCGAGGACGCCGCGGATCTGCTCGCCG
ACGTCGAGCAGGCGCTGGCGAAGTAG

Protein sequence :
MSELGFSTRAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRSALEANLAALESGAHGRAFASGMA
ATDCVLRATLRPGDHIVIPDDAYGGTFRLIDKVFSQWGIEHTPAHVFDTDAMRAAIRPNTKLVWVETPTNPLLSIGDIPA
LAEIAHAAGAKLVVDNTFATPYLQQPLVLGADVVVHSTTKYLGGHSDVVGGALITNDPELDAAFGFLQNGAGAVPGPFDA
YLTMRGTKTLAVRMERHCDNAEAIAGFLAKHPAVSTVIYPGLPEHPGHAVADKQMRRFGGMISVRLHGGRDAALDFCSRT
KIFTLAESLGGVESLIEHPGAMTHASTAGSQLEVPADLVRLSVGIEDAADLLADVEQALAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-71 48
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-69 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-55 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_121043.1 cystathionine gamma-synthase BAC0207 Protein 2e-66 45