Gene Information

Name : lysS (nfa1030)
Accession : YP_116309.1
Strain : Nocardia farcinica IFM 10152
Genome accession: NC_006361
Putative virulence/resistance : Unknown
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 94188 - 97373 bp
Length : 3186 bp
Strand : -
Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
GTGGCCTGCCTGCTGTGGAGTCTGTCGCCTGCGCTGCGGTTCCTGACCGGGCCGCCGCGCCGCTTCGTCGACGACTACTA
CTTCGACGCCCCCGACACCAACGTGATGTGGGCGCTGATCGTGGGCCTGCTCGCCGGCGCGATCGCCAGCCGCAAGCGGA
TCGCCTGGTGGTTGCTGGTCGGCTATCTGACGCTGTTCGCGGTGGCCAACGGGTTGCGCTTCGCCGCCGAGCAGAACATC
AACGCCCTGGTGGCGATGATCGTGCAGGTCGGCGTGGTCGGCCTGTTGATCGCGGCGTGGCCGGAGTTCTACACCCGGGT
GCGGCGCGGGGCCGGCTGGAAGGCGCTGGGCGTGCTGGTCGGTGGGCTGGCGATCGGCTGCCTGCTGGGCTGGGGCCTGG
TGGAGGTGTTCCCCGGCTCGCTGCCGCCGGGCTGGCAGCGGCCCGGCTGGGCGGTGTACCGCGTGACCGCGGCGATCCTG
GTGGAGAACGAGCATTTCGGCGGGCACCCGCGCCCGTTCGTCAATGTGCTGCTCGGCCTGTTCGGCGCGATCGCGTTGCT
GGCGGCGGTGCTCACGCTGCTGCGCTCCCAGCGCGCCGCCAACGCGATGACCGGCCTGGACGAGTCCGCGATCCGCGGCC
TGCTGGAGCATTCGGACGTGGAGGACTCGCTGGGCTACTTCGCGACCCGGCGCGACAAGGCGGTGGTGTTCGCGCCCAGC
GGCAAGGCGGCGGTGACCTACCGCGTCGAACTCGGCGTCTGCCTGGCCAGCGGCGACCCCGTCGGCGTGCGCGAGGCCTG
GCCGCACGCGATCGACGCCTGGCTCCGGCTGGCCGACCGGTTCGGTTGGACACCGGCGGTGATGGGCGCGAGCGAGGAGG
GCGCGACCGCCTATCGCCGCGCGGGCCTGTCGGCGCTGCGCCTCGGCGACGAAGCCGTGCTCGACACCCGCGATTTCTCG
CTGGCCGGTCCCGAGCTGCGGCAGGTGCGGCAGGCCGCCAACCGGTTGCGCAAACAGGGTGTGCGGGTGCGCATCCGCCG
CCACCGCGAGATTCCGTCGGCGGAGTTCGAGCAGATCATGGCCCGCGCCGACGCCTGGCGCGACACCGAGACCGAGCGCG
GCTTCTCCATGGCGCTCGGCCGCCTCGGCGACCCGCTGGACGCGGACTGCCTGCTGGTGGAGGCCGTGGCCGCCGACGAC
CGCGTGCTGGGCATGCTCTCGCTGGTGCCGTGGGGCCGCACGGGGGTGTCGCTGGAGTTGATGCGCCGCGATCCGCAGGG
GCCCAACGGTGTGATGGAGCTGATGATCTCGCAGCTGGCGCTGAACTCCGAGCAGTTCGGCATCACCCGGGTCTCGTTGA
ACTTCGCGGTCTTCCGCTCGGTGTTCGAGGAGGGCGGGCGGATCGGCGCGGGCCCGGTACTGCGGTTGTGGCGCGGCGTG
CTGTTGTTCTTCTCCCGCTGGTGGCAGCTCGAGGCGCTGTACCGGTCCAATGTGAAGTACCAACCCGACTGGGTGCCGCG
GTTCTTCCTGTTCGAGGAACGCAGGCAGCTGCCGCGGGTGGCGGTGGCCAGCGCCCTCGCCGAAGGCTTCCTGCCGCGTC
TGGGCAAGGATCCCGACGCGAGCGCGCACACCGGCGCGCAGAGCGCGGTGCCCGACACGCTCACCGGCCTGCACGCCGAC
GGCAGCCCACCGGACTGGCCGAAACCCGACCTCCTCGACAGCGGCCCGCGCAGGCCCGAGCAGGTCCGGGTGCGCATGGC
GAAGCTGGACCGGATGACGGCGGCGGGTGTGGACGCCTACCCGGTGGCCTACCCGCCGACCCACACCGTCGCCGCGGCCC
GGCGGTCGCCACGCGGGACCACCGTGCGGGTGTGCGGGCGGCTGCTGCGCATCCGCGACTACGGCGGCGTGGTGTTCGCG
CTGCTGCGCGACTGGTCCGACGACATCCAGCTGGTGATCGACCGCGAGCGGGTGGGGGCGGCGCGCAGCGCGGAGTTCGG
CGAGTACTTCGACCTGGGCGATCTCATCGAGGTCAGCGGGCAGATCGGGCGCAGCCGCAGCGGCGAGCTCTCGCTGCTGG
CCGCGGACTGGCGGATGCTGGGCAAGTGCCTGCACCCGCTGCCGGACAAGTGGAAGGGCCTGGCCGACCCGGAGGCGCGG
GTGCGCCAGCGCTACGTCGACATGGCGATCAACCCGGAGACCCGGGACGTGCTCGCCAAGCGCAGCGCGGTGGTCCGCTC
GCTGCGCGAGTCGCTGAACTCCTGGGGCTATCTCGAGGTGGAGACACCCATCCTGCAGCAGGTGCACGGCGGCGCCAACG
CCACCCCGTTCACCACCCACATCAACGCCTACGACCTGGATCTCTACCTGCGTATCGCGCCCGAGCTGTACCTCAAGCGG
CTGTGCGTGGGTGGCATGGAGAAGGTGTTCGAACTGGGCCGCACCTTCCGCAACGAGGGCGTGGACTTCAGCCACAACCC
CGAGTTCACCATCCTCGAGGCCTACGAGGCGCACAGCGACTACATTCGGATGATGCACACCTGCCGGGTGCTCATCCAGA
ACGCCGCGCTCGCGGCGAACGGCTCGATGGTCGCGATGCGGCCGGGCGCGGACGGCGCGCTGGAGCCGGTGGACATCTCC
GGCGACTGGCCGGTCAAGACGGTGCACGGCGCGGTGTCGGCGGCCGTGGGCACCGAGATCACCCCGCGGACCGGCGTCGC
GGAACTGCGCGAACTCTGCGACCGGGTCGGCGTGCCGTATCAGCACGGCTGGGACGAGGGCCAGATCGTGTTGGAGATGT
ACGAGCACCTGGTGGAGGCACGCACCGAGGAACCGACCTTCTACGTCGACTTCCCGACCTCGGTCTCGCCGCTGACGCGG
GCGCACCGCAGCACCCCCGGCGTCACCGAACGCTGGGATCTGGTGGCCTGGGGCGTCGAACTGGGCACCGCCTACAGCGA
ACTCACCGACCCGGTCGAGCAGCGGCGCAGGCTCACCGAACAGTCGGTGCTCGCCGCCAACGGCGACCCGGAGGCGATGG
AGCTGGACGAGGACTTCCTGCAGGCGCTCGAGCACGCCATGCCACCCACCGGCGGCCTCGGCATGGGGGTGGACCGCATC
GTCATGCTCATCACCGGCCGCAGCATCCGCGAGACACTGCCGTTCCCGCTCGTCAAGCCCCGCTGA

Protein sequence :
MACLLWSLSPALRFLTGPPRRFVDDYYFDAPDTNVMWALIVGLLAGAIASRKRIAWWLLVGYLTLFAVANGLRFAAEQNI
NALVAMIVQVGVVGLLIAAWPEFYTRVRRGAGWKALGVLVGGLAIGCLLGWGLVEVFPGSLPPGWQRPGWAVYRVTAAIL
VENEHFGGHPRPFVNVLLGLFGAIALLAAVLTLLRSQRAANAMTGLDESAIRGLLEHSDVEDSLGYFATRRDKAVVFAPS
GKAAVTYRVELGVCLASGDPVGVREAWPHAIDAWLRLADRFGWTPAVMGASEEGATAYRRAGLSALRLGDEAVLDTRDFS
LAGPELRQVRQAANRLRKQGVRVRIRRHREIPSAEFEQIMARADAWRDTETERGFSMALGRLGDPLDADCLLVEAVAADD
RVLGMLSLVPWGRTGVSLELMRRDPQGPNGVMELMISQLALNSEQFGITRVSLNFAVFRSVFEEGGRIGAGPVLRLWRGV
LLFFSRWWQLEALYRSNVKYQPDWVPRFFLFEERRQLPRVAVASALAEGFLPRLGKDPDASAHTGAQSAVPDTLTGLHAD
GSPPDWPKPDLLDSGPRRPEQVRVRMAKLDRMTAAGVDAYPVAYPPTHTVAAARRSPRGTTVRVCGRLLRIRDYGGVVFA
LLRDWSDDIQLVIDRERVGAARSAEFGEYFDLGDLIEVSGQIGRSRSGELSLLAADWRMLGKCLHPLPDKWKGLADPEAR
VRQRYVDMAINPETRDVLAKRSAVVRSLRESLNSWGYLEVETPILQQVHGGANATPFTTHINAYDLDLYLRIAPELYLKR
LCVGGMEKVFELGRTFRNEGVDFSHNPEFTILEAYEAHSDYIRMMHTCRVLIQNAALAANGSMVAMRPGADGALEPVDIS
GDWPVKTVHGAVSAAVGTEITPRTGVAELRELCDRVGVPYQHGWDEGQIVLEMYEHLVEARTEEPTFYVDFPTSVSPLTR
AHRSTPGVTERWDLVAWGVELGTAYSELTDPVEQRRRLTEQSVLAANGDPEAMELDEDFLQALEHAMPPTGGLGMGVDRI
VMLITGRSIRETLPFPLVKPR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-159 45
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 6e-160 45
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-159 45
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-159 45