Gene Information

Name : topA (MS0730)
Accession : YP_087922.1
Strain : Mannheimia succiniciproducens MBEL55E
Genome accession: NC_006300
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 680067 - 682001 bp
Length : 1935 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
ATGCGATTATTTGTAGCGGAAAAACCCAGCCTTGCCCGAGCGATAGCAGATGTTTTGCCTAAGCCCCATCAGCGTGGCGA
CGGTTTTATCAAATGCGGGAAAAATGATTGCGTAACCTGGTGTGTCGGGCATTTATTGGAACAAGCGGAACCCGACGCAT
ACAATCCCATGTTTAAACAATGGCGTTTGGAACATTTGCCCATTGTGCCTAAAAAATGGCGGCTCATTCCCCGCAAAGAA
GTAGCGAAACAGTTAAAAACCGTTGAAAATCTGATTCATCAGGCGGATCAACTGGTCAATGCGGGCGACCCGGACAGAGA
AGGGCAATTACTGGTTGACGAAGTATTTAATTATGCCAATCTCAGCACAGATAAACGTAACGCCATTCAGCGTTGTCTGG
TTAGTGATTTGAATCCGGCTGCGGTGGAAAAAGCGGTAAAAAAATTACAGCCGAATACGAATTTTATCCCGCTTGCCACC
TCCGCCCTTGCCCGCGCCAGAGCGGATTGGCTCTATGGCATTAATATGACGCGCGCTTACACAATTCGCGGTCGCCAAGC
AGGTTACAACGGTGTACTTTCGGTAGGGCGAGTTCAAACGCCCGTGTTGGGGCTTATTGTGCGCCGTGATTTGGAAATCG
AAAATTTTCAGCCGAAAGATTTCTTCGAGGTATTAGCCCATATTCAAACGGAAGACGAAACTCCGCAAAAATTCACCGCA
CTTTGGCAACCAAGCAAAGCCTGCGAAGACTATCAGGATGATGACGGTCGAGTACTTTCCCTCGGCTTAGCCGAAAACGT
TGTAAAACGGATTACCGGGCAACCTGCCGAAGTCACCGAATATACGGACAAACGCGAAAAAGAAACCGCACCGTTGCCCT
ATTCGCTTTCCGCCTTGCAAATTGATGCGGCGAAGCGTTTTGCCATGTCGGCGCAAGATGTGCTCGATACCTGTCAGCGT
TTATATGAAACCCACAAATTAATTACCTACCCGCGTTCCGACTGCCGCTATTTACCGAATGAGCATTTTGCCGAGCGAAT
GCCGGTATTGAATGCGATATCAACGCATTGTAAAGAATATCAACCTTTGCCTGAAGTACTGAATACAGAGCAAAAAAATC
GTTGTTGGAATGATAAAAAAGTAGAAGCCCACCATGCGATCATCCCTACGGCAAAAAATCGCCCGGTAAATCTAAATTCG
CAAGAACTGAATATCTATACGTTAATCGCACGTCAATATCTCATGCAGTTTTGTCCCGATGCGGAATACCGTAAAAGTAA
AATCAGCCTAAAAATTGCCGGCGGCAATTTCGTCGCTCAGGCGCGCAATTTACAGATTGCAGGTTGGAAAGAATTATTAG
GCAAAGAAGATGAAAACGAACAACTTGAGCCGTCGCTTCCGATAGTCAAAAAAGGACAGCAACTATTTTGTGAAAAAGGC
GAAGTCATCAGTAAAAAAACGCAACCGCCTAAACCTTTTACCGATGTGACATTGTTATCGGCAATGACGGGTATTGCGCG
TTTCGTACAAGATAAAGAACTTAAAAAAATCTTACGAGAAACCGACGGATTGGGCACGGAAGCAACCCGGGCGGGTATCA
TCGAATTATTATTCAAACGGGGATTTCTTTATAAAAAAGGACGCAACATTCATAGCTCCGAAGCCGGAAGAATTTTAATT
CAGGCATTGCCCGACATGGCAACCCAGCCGGATATGACGGCGCAATGGGAAGCACAACTTGACGGCATCAGCCGCAAACA
GGCGAGCTATCAACAATTTATGGCGACACTGACCGAACTTTTGCCCGAATTAGTGCAATTTGTAAATTTTTCCGCCTTAC
GAAAATTAAGCGCCGTAGCGAACAATCCTAAGCCGAAAAACTTTAAAAAGAAGGCCAAAATCGCGCAATCGACAGAAACA
AAAAAAGAAGTCTAA

Protein sequence :
MRLFVAEKPSLARAIADVLPKPHQRGDGFIKCGKNDCVTWCVGHLLEQAEPDAYNPMFKQWRLEHLPIVPKKWRLIPRKE
VAKQLKTVENLIHQADQLVNAGDPDREGQLLVDEVFNYANLSTDKRNAIQRCLVSDLNPAAVEKAVKKLQPNTNFIPLAT
SALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAHIQTEDETPQKFTA
LWQPSKACEDYQDDDGRVLSLGLAENVVKRITGQPAEVTEYTDKREKETAPLPYSLSALQIDAAKRFAMSAQDVLDTCQR
LYETHKLITYPRSDCRYLPNEHFAERMPVLNAISTHCKEYQPLPEVLNTEQKNRCWNDKKVEAHHAIIPTAKNRPVNLNS
QELNIYTLIARQYLMQFCPDAEYRKSKISLKIAGGNFVAQARNLQIAGWKELLGKEDENEQLEPSLPIVKKGQQLFCEKG
EVISKKTQPPKPFTDVTLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSSEAGRILI
QALPDMATQPDMTAQWEAQLDGISRKQASYQQFMATLTELLPELVQFVNFSALRKLSAVANNPKPKNFKKKAKIAQSTET
KKEV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 3e-109 43
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 1e-106 41
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 1e-106 41
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 9e-107 41
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 6e-102 41