Gene Information

Name : megL (BCZK4398)
Accession : YP_085976.1
Strain : Bacillus cereus E33L
Genome accession: NC_006274
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 4506676 - 4507854 bp
Length : 1179 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence : 
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACATCAGAGGAACATAAAGGAAGTTTAACACCGCC
TTTATTTCAAACGTCTACATTTACATTTGAGACTGCGCAGCAAGGAGAGGCGAGTTTTGCGGGAGTGGATTCGTCTTATA
TTTACTCAAGACTTGGAAATCCGACTGTGAAACTATTTGAAGAACGTATGGCAGTGTTAGAAGGTGGAGAAGAAGCTCTT
GCTTTCGGATCCGGAATGGCAGCTATTTCAGCGACTTTAATTGGTTTTCTAAAAGCTGGAGATCATATTATTTGTTCAAA
TGGATTATACGGATGCACGTACGGCTTTTTAGAAGTGTTAGAAGAAAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGGCTGATATTGAAAATAAAATTCGCCCAAATACGAAGCTTATTTTCGTTGAAACACCGATTAATCCAACGATG
AAATTAATTGATTTAAAACAAGTAATTCGGGTTGCGAAGCGAAATGGGTTACTTGTTATTGTTGATAATACGTTTTGTTC
ACCTTATTTACAAAGGCCGCTTGAACTTGGCTGTGACGCGGTTGTTCATAGTGCGACAAAATATATTGGTGGTCACGGTG
ATGTTGTAGCGGGTGTAACAATTTGTAAAACGAGAGCGTTAGCTGAAAAAATTCGCCCGATGCGAAAAGATATCGGCGGT
ATTATGGCACCGTTTGATGCATGGTTATTGTTACGCGGATTAAAGACACTAGCGGTAAGAATGGATCGCCATTGTGATAA
TGCAGAAAAAATTGTATCGTTCCTAAAAAATCATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGAGAGTTAGCATCTC
GCCAAATGAAACGGGGCGGTGGCGTTATATCTTTTTCAATTAAAGGTGGGAAAGAAGAGACGCAAGCGTTTATTAATGAT
CTCCACTTTATTACAATTGCAGTAAGTTTAGGAGATACAGAAACGTTAATTCAGCATCCGGCAACGATGACGCACGCTGC
GATTCCAGCTGAGTTAAGACAAGAAATGGGCATTTATGATAATTTAATACGTTTATCTGTCGGTTTAGAATCGTGGGAGG
ATATCGTTTCTGATTTAGAGCAAGCGTTAAAGAAAATATCTACTGTTAGTAATCAATAA

Protein sequence : 
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDSSYIYSRLGNPTVKLFEERMAVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-67 43
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-66 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_085976.1 methionine gamma-lyase BAC0207 Protein 5e-90 48