Gene Information

Name : thyA (BCZK2020)
Accession : YP_083612.1
Strain : Bacillus cereus E33L
Genome accession: NC_006274
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2142898 - 2143854 bp
Length : 957 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACATGCTGAAAATGAATACTTAAATTTATGCCGCCATGTAATGGAACATGGTACGAAGAAAGAAGATCGTACAGG
GACAGGAACTGTATCTGTATTTGGATATCAAATGCGTTTTGATTTAAGTAAAGGTTTTCCTTTATTAACGACAAAGAGAG
TACCGTTTCGCCTTGTAGCAAGTGAATTGCTATGGTTTATGAAAGGTGATACAAATATTCGCTATTTATTGCAGCATAAT
AATAACATTTGGAATGAATGGGCATTTAAGAGCTGGGTAGAAAGCGACGAGTATACTGGTCCTGACATGACTGATTTCGG
TCTTCGTTCACAACAAGATGAGGAATTTAAAGTGCAGTACGATAAGCAAATGGAATTATTTAAAAAGAACGTTTTAGAAG
ATGATGATTTCTCAAATAAATATGGTTATTTAGGAGACGTATACGGTAAGCAGTGGCGTGCTTGGAAAACGACAGCTGGT
GAGACACTTGATCAATTAAAGGATGTAATTGAAATGATTAAGAAGACGCCAGATTCGCGTCGCCTAATTGTTTCTGCTTG
GAATCCGGAAGATGTACCAAGTATGGCATTACCGCCTTGTCATACACTATTCCAATTTTATGTAGCAGATGGCAAACTTT
CTTGTCAGCTATATCAAAGAAGTGGTGACATATTCCTTGGAATTCCATTTAACATTGCAAGTTACTCACTACTGACACAT
TTAATTGCACATGAATGCGGACTTGAAGTGGGAGAATTTGTTCATACAATTGGAGATGCACACATTTATACAAACCATTT
TGAGCAAGTAGAAAAGCAATTGGCACGTGAACCACGTCCATTCCCGAAACTTACACTAAATCCAGATGTGAAATCTGTGT
TTGATTTTGAAATGGAAGATTTAACAATTGAAGGATATGATCCGCATCCAGCAATTAAAGCACCAGTTGCAGTGTAA

Protein sequence :
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHN
NNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQYDKQMELFKKNVLEDDDFSNKYGYLGDVYGKQWRAWKTTAG
ETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTH
LIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-105 65