Gene Information

Name : thyA (STH3117)
Accession : YP_076943.1
Strain : Symbiobacterium thermophilum IAM 14863
Genome accession: NC_006177
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3316818 - 3317669 bp
Length : 852 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
TTGAACATCGAGATCCAGTACCTGGAACTCTGCCGGGAGATCCTGGCGGAGAACGAGCAGGAGATCGCCGAGGGCCGCTG
GACGCCCAACCGGACCGGCATGGGGACGGTGGGCGTCTTCGGCCGCATGCTGAAGCACGACTTCAAGGAAGGGTTTCCCG
CCCTGACCACCAAGAAGCTGTTCTTCAACTCCGTGAAGGCCGAGTTGCTCTGGTTCCTCGCGGGCCGGACCGACCTGGAG
TTCCTGCACGAGCGGGGATGCCACATCTGGGACAAGGACGCGGCCCGCAACGGCGGGAAGCTCGGGCCGATCTACGGCAA
GCAGTGGCGGGCGTGGGAGGGCGCGGACGGCAGGACCTACGACCAGATCGCCTGGGTCATCCAGCAGATCCGGGAGATCG
CCGCCGACCCGGAGCGGCCCCATCCCAACTCCAGGCGGCTGGTCGTCAGCCCCTGGAACGTCGCCGACCTGGAGGAGATG
GCCCTGCCGCCCTGCCACGGGCCGTTCCAGTTCCACGTGAAGGACGGCAGGCTGCACCTGGCCGTGTGGCAGCGCAGCGC
CGACCTGTTCCTGGGAGTGCCCTTCAACATCGCCAGCTACTCGCTGCTGCTGCACATGGTGGCGCAGGTGACCGGGCTGG
CGGTGGGCACGTACACGCATTACCTGAACGACGTGCACATCTACCGCAACCTCCTGGACCAGGTACGGCTGCAGCTCACG
CGGGAGCCGTACCCGCTGCCCAGGCTCTGGCTGAACCCCGAGGTCAGGGAGATCGACCAGTTCACGATGGACGACATCCA
GCTGGTGGACTACAAGCACCACCCGCCGATCCGCGGGGAGCTGTCGACATGA

Protein sequence :
MNIEIQYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSVKAELLWFLAGRTDLE
FLHERGCHIWDKDAARNGGKLGPIYGKQWRAWEGADGRTYDQIAWVIQQIREIAADPERPHPNSRRLVVSPWNVADLEEM
ALPPCHGPFQFHVKDGRLHLAVWQRSADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLT
REPYPLPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELST

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-50 45