Gene Information

Name : nanA (YPTB2742)
Accession : YP_071251.1
Strain : Yersinia pseudotuberculosis IP 32953
Genome accession: NC_006155
Putative virulence/resistance : Virulence
Product : N-acetylneuraminate lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0329
EC number : 4.1.3.3
Position : 3241854 - 3242747 bp
Length : 894 bp
Strand : +
Note : similar to Yersinia pestis YPO3024 nanA, npl; probable N-acetylneuraminate lyase (100% evalue=1.E-170); Vibrio cholerae VC1776 N-acetylneuraminate lyase, (75% evalue=1.E-126)

DNA sequence : 
ATGAAAAAGTTAACCGGCCTGATCGCAGCTCCGCACACTCCCTTTGATGAACAGGGCGAGGTCAATTATCCGGTCATTGA
CCAAATTGCCGAGCATCTGATCAATGATGGCGTGAAAGGCGTTTATGTCTGTGGTACCACTGGCGAAGGCATTCATTGCT
CAGTTGATGAGCGCAAGAAAATTGCTGAACGCTGGGTAAACGCCGCTCAAGGCAAACTGAGCATTACCTTACACACCGGT
GCTCTCAGTATTAAAGATGCGGTTGATCTCTCTCGTCATGCGGAAACACTGGATATCTTCGCAACCTCAGCCATCGGCCC
CTGTTTCTTTAAACCGGGTAATCTGGATGACCTAATCGCTTATTGTCAGGCAATAGCCGCGGCAGCACCGTCGAAGGGCT
TCTATTACTACCACTCCGGTATGTCCGGTGTAAATTTGGACATGGAACAGTTTCTGATCAAAGCGGAATCCAAGATCCCT
AACTTGTCAGGAATTAAATTCAATAACGCTGATTTGTATGAGTTTCAACGCTGTTTACGTGTGAGTGGCGGTAAATTTGA
TATTCCGTTTGGCGTTGATGAACATCTGCCAGGTGGATTAGCTGTAGGGGCTATTGGCGCTGTTGGCAGCACTTATAACT
ATGCCGCTCCGCTGTTCCATAAAATTATCGCTGACTTTAATGCGGGTGATCAGGTTGCGGTACAGCGTGGAATGGATCAC
GTTATCGCCCTGATCCGTGTGCTGGTCGAATTCGGTGGTGTTGCCGCCGGTAAGGCCGCGATGCAATTACATGGTATTGA
TGCCGGTAACCCACGTCTGCCACTGCGTGCCTTGACCAAAGAACAGAAGCAAACCGTGGTTAACAGAATGCGTGACGCTA
TTACGTTGCAGTAA

Protein sequence : 
MKKLTGLIAAPHTPFDEQGEVNYPVIDQIAEHLINDGVKGVYVCGTTGEGIHCSVDERKKIAERWVNAAQGKLSITLHTG
ALSIKDAVDLSRHAETLDIFATSAIGPCFFKPGNLDDLIAYCQAIAAAAPSKGFYYYHSGMSGVNLDMEQFLIKAESKIP
NLSGIKFNNADLYEFQRCLRVSGGKFDIPFGVDEHLPGGLAVGAIGAVGSTYNYAAPLFHKIIADFNAGDQVAVQRGMDH
VIALIRVLVEFGGVAAGKAAMQLHGIDAGNPRLPLRALTKEQKQTVVNRMRDAITLQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC1776 NP_231411.1 N-acetylneuraminate lyase Not tested VPI-2 Protein 3e-102 76
VC0395_A1374 YP_001217317.1 dihydrodipicolinate synthetase family protein Not tested VPI-2 Protein 3e-102 76
VPI2_0024c ACA01841.1 dihydrodipicolinate synthase/N-acetylneuraminate lyase Not tested VPI-2 Protein 9e-102 76

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanA YP_071251.1 N-acetylneuraminate lyase VFG1109 Protein 1e-102 76