Gene Information

Name : guaA (BGB17)
Accession : YP_063260.1
Strain :
Genome accession: NC_006128
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 15721 - 17307 bp
Length : 1587 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAATACGCTTTAATAAGAAAACTTTTATTTGTTTTAAGGACTTATATGATGAATGTTCGTGCAATACTTGTATTAGA
TTTTGGATCCCAATATAGCCAACTAATTGCAAGAAGGATTAGAGAAATTGGAGTTTATACAAAAGTAATACCTTACTATA
CCCCTTTAAAAGAAATTAAAAATATGAACATCGCAGGAATAATACTAAGTGGAGGCCCTGCCTCTGTTTACGCAAAAGAT
GCCCCTACCTTGAACATGGAAATTTTTAATTTAAAAATACCTGTTTTAGGCATATGTTATGGAATGCAATTAATTGTTAA
ATTATTTGGAGGCCTAGTATCTAAAGACTACAAACAAGAATATGGAAGCTCTGAAATCTTTCTAAAAAATGAAAAATCTC
TTTTATTCTCAGAGCTTCCAAACAAATTCCAAATTATTATGAGTCATGGGGATAGTATTGAAAAAATTCCCAATAATTTC
AAACAGTTGGCTTTTACAAAAAACTGTATTGCTTCTATATCAAATGAAGATCAAAAGATTTATGGTCTACAATTTCACCC
AGAAGTAACTCATTCTGAATTTGGCGATCAAATACTTAAAAATTTTGTTTTTAAAATTTGTCAATCTCAAACTAATTGGT
CATTAGAGAGCAATGTAGAAACCATTGTGGAAAAAATTAAACTTAAAGTAGGTAGTAAAAAGGTTATTTTAGGACTTTCT
GGTGGTACAGACTCTTTGGTTTGCGCATTACTTATAAAAAAGGCAATAAAAGAAAATTTAATCTGCGTTTTTGTAAATAC
TGGATTGTTGCGTAAAAATGAAGATAAAAAAATACTAGAATTAAAGCATCAATATGATTTAAATATAAAATACATCGATG
CTTCTGAAAAATTCTTAAACTATTTAAAAAATATAAGTGATCCTGAGGAAAAAAGAAAAATAATAGGAAAAGAATTTGTA
AACGTTTTTGAAAAAATTACTCTAGAAGATCAAAATATAGAATATTTAGCACAAGGAACAATTTATTCCGACGTAATTGA
ATCTAAATCAAAAAATAACGCTTCTTCAAAAATTAAATCTCATCACAACGTAGGGGGACTTCCAGATAAGATGCGTTTAA
AACTTTTAGAACCTTTGAATGAATTTTTTAAGGATGAAATAATTCAAATCGGAATAAATTTAGGCATTAAAAAAGAAGCT
CTTTATAGACACCCATTCCCAGGCCCAGGACTAGCCATAAGAATAATTGGAGAAGTAACGCAAGAGAAGATCAATATCTT
GCAAGAAGCAGAAAATATTCTCACAGAGGAGCTTTTTACAAATGACTTATATTATGAAATAAGACAAGCATTTGTTGTAT
TGCTGCCTGTTAAATCTGTAGGCGTAATGGGAGATCAAAGGACATATGAATATACAGCTGTCATTAGATGTGTCAATACT
CAAGACTTCATGACTGCAGAATGGACTGAACTTCCTTATAATTTTTTAAGAAAAGTTTCTTCAAGAATAATTAATGAAGT
TAGAGGTATAAATAGAGTTTGTTATGATATATCTTCTAAGCCTCCATCAACCATAGAATGGGAATAA

Protein sequence :
MKYALIRKLLFVLRTYMMNVRAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNIAGIILSGGPASVYAKD
APTLNMEIFNLKIPVLGICYGMQLIVKLFGGLVSKDYKQEYGSSEIFLKNEKSLLFSELPNKFQIIMSHGDSIEKIPNNF
KQLAFTKNCIASISNEDQKIYGLQFHPEVTHSEFGDQILKNFVFKICQSQTNWSLESNVETIVEKIKLKVGSKKVILGLS
GGTDSLVCALLIKKAIKENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASEKFLNYLKNISDPEEKRKIIGKEFV
NVFEKITLEDQNIEYLAQGTIYSDVIESKSKNNASSKIKSHHNVGGLPDKMRLKLLEPLNEFFKDEIIQIGINLGIKKEA
LYRHPFPGPGLAIRIIGEVTQEKINILQEAENILTEELFTNDLYYEIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNT
QDFMTAEWTELPYNFLRKVSSRIINEVRGINRVCYDISSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-120 50
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-120 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-120 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-106 44