Gene Information

Name : thyA (Lxx09930)
Accession : YP_061970.1
Strain : Leifsonia xyli CTCB07
Genome accession: NC_006087
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1015441 - 1016250 bp
Length : 810 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGACCACGCCGATCCCGACCCCGTACGAAGACCTGCTGCGCGACGTCCTCGCGAACGGCAGCCACAAATCCGACCGCAC
CGGGACGGGCACGCGCAGCGTCTTCGGACGCCAGCTCCGGTTCGACCTCGCGGACGGCTTCCCGCTGATCACGACCAAGC
GGGTCCACTTCAAGTCGATCGCGTACGAACTGCTCTGGTTCCTCCGCGGCGACAGCAATGTCGGCTGGCTGCGCGAGAAT
GGCGTGAGCATCTGGGACGAGTGGGCCGACGAGCGGGGCGAACTCGGCCCTGTCTACGGGGTTCAGTGGCGCTCCTGGCC
GTCCCCGGACGGCACGCACATCGACCAAATCCAGCAGGTCGTCGACACGCTCCGCCGCGACCCGGACTCGCGCCGCATCA
TCGTCTCCGCCTGGAACGTCGCGGACATCCCGGATATGGCGCTCGCGCCCTGCCACGCCTTCTTCCAGTTCTATGTCGCC
GACGGCAAGCTCTCCTGCCAGCTGTACCAGCGCAGCGCCGACATGTTCCTCGGCGTTCCGTTCAACATTGCGAGCTACGC
GCTCCTCACGCTCATGGTCGCCCAGCAGGTGGGACTCGAACCGGGCGAGTTCGTCTGGACGGGCGGGGACGTCCACATCT
ACGACAACCACATCGAGCAGGTGAACGAGCAGCTGAGCCGTAACCCGTTCCCAGCTCCTGCGCTTCGCTTCGCGCGCAGA
CCGGAAAGCGTCTTCGACTACCGCTACGAGGACTTCGTGCTCGAGGGCTACCGGCACCACCCGGCCATCCGCGCCGCCGT
CGCGGTATGA

Protein sequence :
MTTPIPTPYEDLLRDVLANGSHKSDRTGTGTRSVFGRQLRFDLADGFPLITTKRVHFKSIAYELLWFLRGDSNVGWLREN
GVSIWDEWADERGELGPVYGVQWRSWPSPDGTHIDQIQQVVDTLRRDPDSRRIIVSAWNVADIPDMALAPCHAFFQFYVA
DGKLSCQLYQRSADMFLGVPFNIASYALLTLMVAQQVGLEPGEFVWTGGDVHIYDNHIEQVNEQLSRNPFPAPALRFARR
PESVFDYRYEDFVLEGYRHHPAIRAAVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 6e-89 68
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-57 43