Gene Information

Name : M6_Spy1165 (M6_Spy1165)
Accession : YP_060483.1
Strain : Streptococcus pyogenes MGAS10394
Genome accession: NC_006086
Putative virulence/resistance : Resistance
Product : macrolide ABC transporter ATPase
Function : -
COG functional category : R : General function prediction only
COG ID : COG0488
EC number : -
Position : 1165958 - 1167421 bp
Length : 1464 bp
Strand : -
Note : -

DNA sequence :
ATGGAATTAATATTAAAAGCAAAAGACATTAGTGTGGAATTCAAAGGACACGATGTTTTAGATATAAATGAATTAGAAGT
ATATGATTATGACCGTATTGGTTTAGTAGGAGCAAATGGTGCAGGAAAAAGCACTTTATTCAAGGTACTTTTAGGAGAAT
TAATTCCCCCAGGATGTAAAATGAATCATCTGGGTGAACTTGCCTATATTCCCCAGTTGGACGAAGTAACTCTGCAGGAG
GAAAAAGATTTTGCGCTTGTAGGCAAGCTAGGTGTTGAGCAATTAAATATACAGACCATGAGCGGTGGTGAAGAAACAAG
GCTTAAAATAGCACAGGCCTTATCGGCACAGGTTCATGGTATTTTAGCGGATGAACCTACGAGCCATTTAGACCGTGAAG
GAATTGATTTTCTAATAGGACAGCTAAAATATTTTACAGGTGCACTGTTAGTTATTAGCCATGACCGCTATTTTCTTGAT
GAAATAGTAGATAAAATATGGGAACTGAAAGATGGCAAAATCACTGAGTATTGGGGAAACTATTCTGATTATCTTCGTCA
GAAAGAGGAAGAACGTAAGAGACAAGCTGCAGAATACGAACAATTTATTGCGGAACGTGCTCGATTGGAAAGGGCTGCGG
AGGAAAAGCGAAAACAGGCTCGTAAAATAGAACAGAAGGCAAAAGGTTCTTCAAAGAAAAAAAGTACTGAAGGCGGAGGG
CGTTTAGCTCATCAAAAATCAATAGGAAGTAAGGAAAAAAAGATGCATAATGCCGCTAAATCCCTAGAGAACAGGATTGC
GGCATTAGGAAAAGTAGAAGCTCCGGAAGGCATTCGCAGAATTCGTTTCAGGCAAAGTAAAGCATTGGAGCTCCATAATC
CATACCCTATAGTCGGTGCGGAAATTAATAAAGTATTTGGGGATAAGGCACTGTTTGAAAATGCATCTTTTCAAATTCCG
CTAGGAGCAAAAGTGGCATTAACGGGTGGTAATGGAACCGGAAAAACAACTTTAATCCAAATGATCTTAAACCATGAAGA
AGGAATTTCTATTTCACCTAAGGCAAAAATAGGTTACTTTGCACAGAATGGTTACAAGTACAACAGTAATCAGAATGTTA
TGGAGTTTATGCAGAAGGATTGTGATTACAATATATCAGAAATTCGTTCTGTGCTAGCATCTATGGGGTTCAAACAGAAC
GATATTGGAAAAAGCTTATCTGTTTTAAGCGGTGGAGAAATTATAAAATTGTTGCTTGCTAAAATGCTCATGGGTAGATA
TAACATCCTAATAATGGATGAACCCAGTAACTTCCTTGACATACCAAGTTTAGAGGCTTTGGAAATACTAATGAAGGAGT
ACACCGGAACTATCGTGTTTATCACCCACGATAAACGATTACTCGAAAATGTAGCTGATGTAGTTTATGAAATTAGAGAT
AAGAAAATTAAGCTGAAACATTAA

Protein sequence :
MELILKAKDISVEFKGHDVLDINELEVYDYDRIGLVGANGAGKSTLFKVLLGELIPPGCKMNHLGELAYIPQLDEVTLQE
EKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKRQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEGGG
RLAHQKSIGSKEKKMHNAAKSLENRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIP
LGAKVALTGGNGTGKTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQN
DIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
KKIKLKH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
msr(E) YP_005176244.1 macrolide efflux protein Not tested ICEPmu1 Protein 4e-137 62

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
M6_Spy1165 YP_060483.1 macrolide ABC transporter ATPase NC_012469.1.7685970. Protein 0.0 98