Gene Information

Name : thyA (Mfl419)
Accession : YP_053662.1
Strain : Mesoplasma florum L1
Genome accession: NC_006055
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 491075 - 491941 bp
Length : 867 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAATATTTAGAATTAGTTAATGAAATTTTAAAAGATGGAGAAAAAAGAGAAGATCGTACAAACACAGGAACAAT
ATCTAAGTTTGGTGTACAAAAAAGATATGATTTACGTGAAGGTTTTCCATTACTAACAACTAAAAAAGTTTTTTATAAAG
CAATCTTTCATGAGATGTTATGGTTTATAAAAGGTGATACCAATATTAAATACTTGGTTGAGAATAATGTAAAAATTTGA
AATGAATGACCATATGAAAATTTTAAAAAATCATCTGAGTTCAATAATGAGACTTTACAAGAGTTTGTTGAAAGATTAAA
GAATGATAATGAGTTCTGTAATAAATGAGGAGATTTAGGACCTGTTTATGGAAAACAATGAAGAGACTTTGGTGGAATTG
ATCAATTTGCAAAACTAATTAATGATATTAAGAAAAATCCATTTTCAAGAAGACATATTGTTTCAGCATGAAATCCAGCT
GAAGTTGATAACATGTTGTTACCACCATGTCATTCTTTTTGACAAGTTTATGTTTCAAAAGACGGTTGATTAGATTTACA
ACTATACCAAAGAAGTGGTGATGTGTTTTTAGGAGTGCCATTTAATATAGCATCGTATGCGTTACTAATGGAATTAATCG
CAAAAGAATGTAACTTAAAAGCAAGATACTTTGTTCATACAATTGGGGATGCTCATATTTATTTAAACCATCTAGAACAA
ATTAATGAGCAATTAAAAAGAAAACCATTGCCACTATGCAAAATTAAGATTAATTCTGAAAAATCAATTTTTGATATTGC
ATTTGAGGACATTGAAATTGAAGGTTATGAAAGTCATGCTAAAATAACAGGAGAAGTTGCAGTTTAG

Protein sequence :
MKQYLELVNEILKDGEKREDRTNTGTISKFGVQKRYDLREGFPLLTTKKVFYKAIFHEMLWFIKGDTNIKYLVENNVKIW
NEWPYENFKKSSEFNNETLQEFVERLKNDNEFCNKWGDLGPVYGKQWRDFGGIDQFAKLINDIKKNPFSRRHIVSAWNPA
EVDNMLLPPCHSFWQVYVSKDGWLDLQLYQRSGDVFLGVPFNIASYALLMELIAKECNLKARYFVHTIGDAHIYLNHLEQ
INEQLKRKPLPLCKIKINSEKSIFDIAFEDIEIEGYESHAKITGEVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-66 54
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 4e-48 46