Gene Information

Name : guaA (BQ01710)
Accession : YP_031880.1
Strain : Bartonella quintana Toulouse
Genome accession: NC_005955
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 224344 - 225900 bp
Length : 1557 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGCATATCACATCCAGACACTGTTCTTATCATTGATTTTGGTTCACAAGTTACGCAACTTATCGCACGGCGGGTGCG
AGCAATGGGTGTTTATTGTGAAATTGTTCCTTTTCAATTAGCTTTAGAAGGTGTCAAGCGGCTAAGACCTCAAGCTGTTA
TTTTATCAGGCAGTCCTTATTCAGTGATTGATGACGGTTCACCGCGTGCGCCGATGGAAATTTTTGAAATTGGTGTTCCA
GTTCTTGGTATTTGTTATGGTGAACAAGTCATGTGTGTTCAGCTTGGTGGAAAAGTTGAATCAGGACATCGGCGTGAATT
TGGACGGGCTTTTTTGGAGGTGCAAGAAAAGAGTGCACTTTTTGATGGTGTATGGGAAAAAGGTTCCTGTTATCAAGTAT
GGATGAGTCACGGTGATCATGTGGCAGCTTTACCAGAAGGCTTTCGTGTAATAGGAACATCAAAAGGCGCTCCCTATGCT
GCCATTGCTGATGAAAAAAGGTGCCTTTATGCAGTGCAGTTTCATCCTGAAGTTGTTCATACACCCGATGGTACAAAACT
TTTGCAAAATTTTGTTCATAAAATTTCTGGTCTTAAAGGCAATTGGTCAATGGCTTCTTATCGTGATCAGGCAATTGCTA
CGATACGGAAGAAAGTTGGAAAAAGTCGTGTCATCTGTGGTCTTTCAGGTGGTGTGGATTCATCAGTTGTGGCTGTACTT
CTCCATGAAGCAATAGGAGATCAACTGACATGTATTTTGGTAGACCATGGGTTAATGCGCAAAAATGAGGCTGAAGAAGT
TCTTAAATTATTCCGAGATCATTATAATATCGAGCTTATTCACGTTAATGCTGCTAATATTTTTCTCAATGCTTTAGAAG
GTGAGACAGATCCAGAGAAAAAGCGCAAAACGATTGGCCGCCTTTTTATTGAAGTTTTTGAAGAAGAAACCAAAAAAATA
GAAGGTGTAGAATTTTTAGCACAGGGCACGCTTTATCCAGATGTCATTGAAAGTGTATCAGCTATTGGTGAATCGGTAAC
AATTAAAAGCCATCATAATGTAGGGGGATTGCCGGAGCGGATGAACATGAAACTTGTGGAGCCGTTGCGTGAGCTCTTTA
AGGATGAAGTTCGTTCTTTGGGGCGAGAGTTAGGATTGCCGGAGCAGTTTCTTGGCCGTCATCCTTTTCCAGGGCCCGGT
CTTGCAATTCGTTGTCCAGGTGCAGTGACACGTGAAAAATTAGAAATTATACGTGAAGCAGACGCCATTTACCTTGATGA
AATCTGTAAAGCTGGTCTTTATGATGAAATTTGGCAGGCATTTGTTGTTCTTCTTCCTGTGCAGACTGTCGGTGTTATGG
GTGATGGACGCACTTATGAATTTGTTTGTGCTCTTCGCGCGGTAACATCTGTAGATGGAATGACCGCTGATTTCTATCCC
TATGATATGGAATTTTTAAGTAAAACAGCAGCACGTATTATTAACGAAGTGAGGGGAATTAATCGGGTTGTTTATGATAT
AACGTCAAAGCCTCCTGGTACTATTGAATGGGAATGA

Protein sequence :
MSISHPDTVLIIDFGSQVTQLIARRVRAMGVYCEIVPFQLALEGVKRLRPQAVILSGSPYSVIDDGSPRAPMEIFEIGVP
VLGICYGEQVMCVQLGGKVESGHRREFGRAFLEVQEKSALFDGVWEKGSCYQVWMSHGDHVAALPEGFRVIGTSKGAPYA
AIADEKRCLYAVQFHPEVVHTPDGTKLLQNFVHKISGLKGNWSMASYRDQAIATIRKKVGKSRVICGLSGGVDSSVVAVL
LHEAIGDQLTCILVDHGLMRKNEAEEVLKLFRDHYNIELIHVNAANIFLNALEGETDPEKKRKTIGRLFIEVFEEETKKI
EGVEFLAQGTLYPDVIESVSAIGESVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRSLGRELGLPEQFLGRHPFPGPG
LAIRCPGAVTREKLEIIREADAIYLDEICKAGLYDEIWQAFVVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADFYP
YDMEFLSKTAARIINEVRGINRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-137 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-137 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-137 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-116 51