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Name : ddl (TTC1223) Accession : YP_005192.1 Strain : Thermus thermophilus HB27 Genome accession: NC_005835 Putative virulence/resistance : Resistance Product : D-alanyl-alanine synthetase A Function : - COG functional category : M : Cell wall/membrane/envelope biogenesis COG ID : COG1181 EC number : 6.3.2.4 Position : 1186711 - 1187670 bp Length : 960 bp Strand : - Note : D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli DNA sequence : ATGAGGGTTCTTCTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTCTCCGCGGAAGGGGTTCTGCGCCA CATGCCCTTCCCCACGGACCTCGCCGTGATCGCCCGGGACGGGCGCTGGCTTCTGGGGGAAAAGGCCTTGGCCGCCTTGG AGGCCAAGGCGGCGCCCGAGGGGGAGCATCCCTTCCCCCCGCCCCTCCCCTGGGAGCGGTACGATGTGGTCTTTCCCTTG CTCCACGGCCGCTTCGGCGAGGACGGGACGGTCCAGGGCTTTCTGGAGCTTTTGGGCAAGCCCTACGTGGGGGCGGGGGT GGCGGCGAGCGCCCTCTGCATGGACAAGGACCTGAGCAAGCGGGTCCTCGCCCAGGCGGGGGTGCCCGTGGTCCCCTGGG TGGCGGTGCGGAAGGGCGAGCCCTCCATGGTGCCCTTTGACCCCCCCTTCTTCGTCAAGCCGGCCAACACCGGCTCCAGC GTGGGGATAAGCCGGGTGGAACGCTTTCAGGACCTTGAGGCCGCCCTGGCCTTGGCCTTCCGCTACGACGAGAAAGCGGT GGTGGAGAAGGCCCTCTCCCCGGTGCGGGAGCTGGAGGTGGGGGTCTTGGGCAACGTCTTCGGCGAGGCGAGCCCCGTGG GCGAGGTGCGCTACGAGGCGCCCTTCTACGACTACGAAACCAAGTACACCCCGGGCCGGGCCGAGCTCCTCATCCCCGCG CCCTTGGACCCCGGCACCCAGGAGACCGTCCAGGAGCTCGCCCTCAAGGCCTACAAGGTGCTCGGGGTGCGGGGGATGGC CCGGGTGGACTTCTTCCTCGCGGAGGGGGAGGTTTACCTGAACGAGCTCAACACCATCCCCGGCTTCACCCCCACGAGCA TGTACCCCCGCCTCTTTGAGGCGGGGGGGGTGGCCTACCCGGAGCTTCTCAGGCGCCTGGTGGAGCTCGCCCTCACCTAA Protein sequence : MRVLLIAGGVSPEHEVSLLSAEGVLRHMPFPTDLAVIARDGRWLLGEKALAALEAKAAPEGEHPFPPPLPWERYDVVFPL LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPSMVPFDPPFFVKPANTGSS VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGEVYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| vanB | YP_008394259.1 | Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase | Not tested | Not named | Protein | 9e-39 | 41 |
| vanB | NP_815951.1 | D-alanine--D-lactate ligase | Not tested | Not named | Protein | 2e-38 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AF277571.gene.p01 | Protein | 1e-40 | 42 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | NC_014475.1.orf3.gen | Protein | 2e-39 | 42 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | NC_005054.2598280.p0 | Protein | 2e-39 | 42 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AY489045.gene.p01 | Protein | 1e-39 | 42 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AF130997.1.orf4.gene | Protein | 6e-41 | 42 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AY145441.gene.p01 | Protein | 2e-38 | 41 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AF310956.2.orf5.gene | Protein | 7e-38 | 41 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | U00456.gene.p01 | Protein | 1e-38 | 41 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | U35369.1.gene6.p01 | Protein | 1e-38 | 41 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | AE016830.1.gene2250. | Protein | 1e-38 | 41 |
| ddl | YP_005192.1 | D-alanyl-alanine synthetase A | L29638.gene.p01 | Protein | 2e-41 | 41 |
