Gene Information

Name : intB (YP_0646)
Accession : NP_992037.1
Strain : Yersinia pestis 91001
Genome accession: NC_005810
Putative virulence/resistance : Unknown
Product : integrase
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0582
EC number : -
Position : 690406 - 691701 bp
Length : 1296 bp
Strand : +
Note : highly similar to Yersinia pestis CO92 intB and Yersinia pestis KIM intB. Contains Phage integrase (Interpro|IPR002104, (GO:0015074))

DNA sequence : 
TTGTACCCACGCAGAACCCTTGAAAGGATACTCAACATGGCTCTGAGTGATGTGAAGGTTCGTACAGCCAAGCCTGAAGC
AAAAGCCTATAAACTTACCGACGGCGAAGGCATGGTGTTACTGGTTCACCCTAACGGCTCGAAATACTGGCGGCTACGCT
ATCGCTTTGACGGTAAAGAAAAGATGTTGGCGTTGGGGAAGTACCCTGAAATATCACTGGCTGATGCCAGGGCACGGCGT
GACGAAGCTCGTAAGCAGTTAGCTAATGGTGTGGACCCAAGTGAGAGCAAGAAAGCCGTTAAGGTAGAGCAGGAGCAAGA
AGCGATAACTTTTGAAGTGGTAGCCAGAGAGTGGCATGCCAGTAATCGTCAATGGTCAGAAGCTCACAGTGCTCGAGTAC
TCAAAAGCTTAGAGGACAATCTCTTTCAAGCCATTGGCAAACGGAATATCGCAGACCTCGGAACCCGTGATCTTTTACCT
CCAATTAAAGCCGTAGAGATGGCTGGACGTCTTCAGGTGGCTTCCCGCCTGCAACAACGAACCACAGCAATAATGCGCTA
TGCAGTTCAAAGCGGTTTAATTGATTACAACCCCGCGCAGGAGATGGCGGGCGCTGTTGCTACCGGTAAAAGAAAGCACC
GCGCTGCACTCGAGTTAAACCGTGTTTCAGAGTTACTTCATCGCATCGACTACTACAGTGGCAGGCCACTCACTCGACTA
GCGGTAGAATTGACTTTATTGGTCTTTATCCGTTCCAGTGAATTACGCTTCGCCCGTTGGTCAGAAGTCGATTTTGAAAC
TGCAATGTGGACGATTCCGGGAGAACGTGAACCACTGGAAGGTGTTAAGCATTCACATCGAGGTTCAAAAATGCGCACTC
CCCATCTTATCCCCTTATCCCGTCAAGCTCTCGCCATTCTGGAAAAGATCAAAAGCATGAGTGGAAACCGTGAGCTGATC
TTTATCGGTGATCACGACCCACGTAAACCGATGAGTGAAAACACGGTAAACAAAGCCCTACGCGTGATGGGATATGACAC
GAAAGTTGAAGTCTGTGGCCACGGTTTCAGAACCATGGCTTGTAGTTCATTGATTGAGTCTGGATTGTGGTCGAGGGATG
CAGTAGAACGGCAGATGAGTCATCAGGAGCGCAACTCTGTGCGTGCGGCTTATATCCATAAAGCCGAGCACTTAGATGAG
CGCAGATTGATGATTCAGTGGTGGGCTGATTACTTGGATGCGAATCGGGAGAAGGGGGTTAGTCCGTTTGATTTTGCGAA
GTTGAATACGAGCTGA

Protein sequence : 
MYPRRTLERILNMALSDVKVRTAKPEAKAYKLTDGEGMVLLVHPNGSKYWRLRYRFDGKEKMLALGKYPEISLADARARR
DEARKQLANGVDPSESKKAVKVEQEQEAITFEVVAREWHASNRQWSEAHSARVLKSLEDNLFQAIGKRNIADLGTRDLLP
PIKAVEMAGRLQVASRLQQRTTAIMRYAVQSGLIDYNPAQEMAGAVATGKRKHRAALELNRVSELLHRIDYYSGRPLTRL
AVELTLLVFIRSSELRFARWSEVDFETAMWTIPGEREPLEGVKHSHRGSKMRTPHLIPLSRQALAILEKIKSMSGNRELI
FIGDHDPRKPMSENTVNKALRVMGYDTKVEVCGHGFRTMACSSLIESGLWSRDAVERQMSHQERNSVRAAYIHKAEHLDE
RRLMIQWWADYLDANREKGVSPFDFAKLNTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
intB CAD42017.1 bacteriophage P4 integrase Not tested PAI II 536 Protein 4e-149 79
S4822 NP_838459.1 P4-type integrase Not tested SHI-1 Protein 1e-144 70
SF2964 NP_708738.1 P4-type integrase Not tested SHI-1 Protein 1e-144 70
c5216 NP_757064.1 prophage P4 integrase Not tested PAI II CFT073 Protein 9e-145 70
int AAK00456.1 Int Not tested SHI-1 Protein 6e-135 70
ECO111_3718 YP_003236059.1 putative integrase Not tested LEE Protein 1e-142 69
APECO1_3534 YP_854214.1 P4-like integrase Not tested PAI I APEC-O1 Protein 2e-144 69
ORF_1 AAZ04412.1 phage integrase Not tested PAI I APEC-O1 Protein 1e-144 69
int AAL51003.1 CP4-like integrase Not tested LEE Protein 1e-142 69
ECO103_3550 YP_003223418.1 integrase Not tested LEE Protein 5e-143 69
intP4 CAE85151.1 CP4 integrase protein Not tested PAI V 536 Protein 5e-143 69
ECO26_5300 YP_003232178.1 integrase Not tested LEE Protein 5e-143 69
int AAK16198.1 Int Not tested PAI-I AL862 Protein 3e-143 69
c3556 NP_755431.1 prophage P4 integrase Not tested PAI I CFT073 Protein 1e-143 69
int ADD91747.1 P4 integrase Not tested PAI-I AL862 Protein 3e-143 69
int-phe AAL57571.1 CP4-like integrase Not tested LEE Protein 3e-143 69
int CAC81896.1 integrase Not tested LEE II Protein 2e-133 69
ECUMN_3322 YP_002414004.1 integrase Not tested Not named Protein 8e-142 69
int AAL51028.1 CP4-like integrase Not tested LEE Protein 3e-143 69
Z4313 NP_289539.1 pathogenicity island integrase Not tested OI-122 Protein 2e-142 69
int-phe AAL60261.1 Int-phe Not tested LEE Protein 3e-143 69
int AAT48697.1 CP4-like integrase Not tested PAI I 4787 Protein 2e-142 69
SESS1296_03598 AFO66301.1 bacteriophage integrase Not tested SESS LEE Protein 1e-125 62
SESS1635_03816 AFO66367.1 bacteriophage integrase Not tested SESS LEE Protein 1e-125 62
STY4821 NP_458899.1 integrase Not tested SPI-10 Protein 2e-114 58
APECO1_1051 YP_853069.1 phage integrase Not tested PAI IV APEC-O1 Protein 1e-81 57
int2 NP_993013.1 integrase Not tested HPI Protein 1e-107 56
int CAA08754.1 integrase Not tested HPI Protein 3e-108 56
int CAA21384.1 - Not tested HPI Protein 1e-107 56
int YP_002346908.1 integrase Not tested HPI Protein 1e-107 56
y2393 NP_669700.1 prophage integrase Not tested HPI Protein 1e-107 56
intB AAD37509.1 P4-like integrase Not tested PAI IV 536 Protein 2e-93 56
unnamed AAD17660.1 unknown Not tested HPI Protein 7e-105 55
int CAB59974.1 integrase Not tested HPI Protein 6e-109 55
int NP_458759.1 bacteriophage integrase Not tested SPI-7 Protein 2e-108 54
int NP_807963.1 bacteriophage integrase Not tested SPI-7 Protein 2e-108 54
unnamed ABR13507.1 phage integrase Not tested PAGI-6 Protein 2e-104 53
int AAC31482.1 CP4-like integrase Not tested LEE Protein 2e-78 43
int ACU09430.1 integrase Not tested LEE Protein 2e-78 43
intL NP_290239.1 integrase for prophage 933L and the LEE pathogenicity island Not tested LEE Protein 2e-78 43
ECs4534 NP_312561.1 integrase Not tested LEE Protein 2e-78 43
int AAD44730.1 Int Not tested SHI-2 Protein 4e-79 43
int CAC39282.1 integrase Not tested LPA Protein 7e-80 43
aec33 AAW51716.1 Int Not tested AGI-3 Protein 5e-80 43
int AAD54663.1 Sai integrase Not tested SHI-2 Protein 5e-78 43
S4835 NP_839238.1 integrase Not tested SHI-2 Protein 7e-78 43
SF3698 NP_709437.1 integrase Not tested SHI-2 Protein 7e-78 43
unnamed AFX83955.1 integrase Not tested SE-PAI Protein 3e-69 42
ESA_03025 YP_001439090.1 hypothetical protein Not tested Not named Protein 7e-69 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
intB NP_992037.1 integrase VFG1536 Protein 2e-149 79
intB NP_992037.1 integrase VFG0626 Protein 5e-145 70
intB NP_992037.1 integrase VFG1693 Protein 6e-144 69
intB NP_992037.1 integrase VFG0783 Protein 1e-78 43
intB NP_992037.1 integrase VFG0598 Protein 3e-78 43