Gene Information

Name : fliI1 (YP_0421)
Accession : NP_991815.1
Strain : Yersinia pestis 91001
Genome accession: NC_005810
Putative virulence/resistance : Virulence
Product : type III secretion system ATPase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 447214 - 448554 bp
Length : 1341 bp
Strand : +
Note : highly similar to Yersinia pestis CO92 YPO0267 and Yersinia pestis KIM fliI. Contains H+-transporting two-sector ATPase, alpha/beta subunit, central region (Interpro|IPR000194, (GO:0006818)). Contains Disease resistance protein (Interpro|IPR000767, (GO:00

DNA sequence :
TTGATGAAACTGCCTGATATCGCGCGGTTAACCCCCCGCCTGCAACAACAACTCACGCGACCGTCGGCACCACCGGAGGG
CTTGCGTTACCGTGGGCCGATTGTGGAGATTGGGCCGACCTTGTTACGAGCCAGCCTACCCAATGTGGCGCAGGGTGAAT
TATGCCGCATTGAACCGCAAGGGATGTTAGCTGAAGTGGTATCGATTGAGCAGGAAATGGCCTTGTTATCCCCCTTTGCC
TCTTCAGATGGCCTGCGTTGTGGGCAATGGGTGACGCCACTTGGACACATGCACCGGGTACAGGTGGGGGCTGATTTGGC
CGGGCGGATCTTGGATGGCCTAGGTGCTCCGATAGACGGCGGCCCCCCGCTGACGGGGCAGTGGCGTGAACTGGATTGCC
CCCCGCCTAGCCCATTAACCCGCCAGCCGGTAGAGCAAATGCTGACCACCGGAATCCGCGCGATTGATGGGATATTGAGC
TGTGGCGAGGGCCAGCGTATTGGTATTTTTGCCGCCGCTGGCGTTGGGAAAAGTACTTTATTGAGCATGTTATGTGCTGA
TAGTGCGGCCGATGTGATGGTGCTGGCACTGATTGGTGAGCGTGGGCGGGAGGTGCGCGAATTTCTTGAACAGGTGCTGA
CTCCAGAGGCGCGTGCGCGCACCGTGGTGGTGGTGGCGACCTCTGACCGGCCAGCATTGGAGCGGTTGAAGGGGCTGTCT
ACTGCCACCACGGTGGCGGAGTATTTTCGCGAACGTGGATTGAAGGTGTTGTTACTGGCGGATTCACTGACCCGCTATGC
CCGTGCCGCCCGTGAAATTGGTCTGGCGGCAGGTGAGCCACCGGCTGCTGGCAGTTTCCCCCCAAGTGTTTTTGCCAACT
TACCCCGTCTGTTGGAGCGAACGGGTAACAGTGATCGCGGCAGCATTACGGCTTTTTATACCGTGCTGGTGGAGGGAGAT
GACATGAATGAACCGGTGGCCGATGAAGTGCGTTCGCTGTTGGATGGGCACATCGTTTTATCACGACGGTTGGCCGGTGC
CGGGCATTATCCGGCGATTGATATTGCCGCCAGCGTCAGCCGTATCATGCCGCAAATCGTTAGTGCCGGGCAGTTGGCGA
TGGCACAAAAACTACGGCGAATGCTGGCCTGTTATCAGGAGATCGAGCTGTTGGTGCAGATTGGTGAATATCAGGCAGGA
GAAGACCTACAGGCTGATGAAGCCTTACAACGCTATCCGGCAATATGCGCCTTTTTACAACAAGACCACAGCCTAACGCG
TGACCCAGATACTGCTCATCTTGATACCACTCTGGAACACCTGGCGCAGGTTGTCGGTTGA

Protein sequence :
MMKLPDIARLTPRLQQQLTRPSAPPEGLRYRGPIVEIGPTLLRASLPNVAQGELCRIEPQGMLAEVVSIEQEMALLSPFA
SSDGLRCGQWVTPLGHMHRVQVGADLAGRILDGLGAPIDGGPPLTGQWRELDCPPPSPLTRQPVEQMLTTGIRAIDGILS
CGEGQRIGIFAAAGVGKSTLLSMLCADSAADVMVLALIGERGREVREFLEQVLTPEARARTVVVVATSDRPALERLKGLS
TATTVAEYFRERGLKVLLLADSLTRYARAAREIGLAAGEPPAAGSFPPSVFANLPRLLERTGNSDRGSITAFYTVLVEGD
DMNEPVADEVRSLLDGHIVLSRRLAGAGHYPAIDIAASVSRIMPQIVSAGQLAMAQKLRRMLACYQEIELLVQIGEYQAG
EDLQADEALQRYPAICAFLQQDHSLTRDPDTAHLDTTLEHLAQVVG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 0.0 100
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-111 59
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 5e-112 59
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 9e-112 59
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 5e-112 59
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-112 59
lscN AAO18044.1 LscN Virulence TTSS locus Protein 4e-99 56
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-95 52
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-95 52
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-98 52
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-98 52
unnamed AAL06369.1 EscN Virulence LEE Protein 1e-98 52
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-94 51
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 3e-94 51
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 8e-96 50
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-94 50
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-95 50
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 3e-95 50
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 8e-96 50
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 9e-76 50
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 2e-101 50
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-101 50
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-101 50
escN CAI43874.1 EscN protein Virulence LEE Protein 9e-102 50
escN AAK26715.1 EscN Virulence LEE Protein 6e-101 50
escN AAL57542.1 EscN Virulence LEE Protein 6e-101 50
escN AAC38383.1 EscN Virulence LEE Protein 4e-101 50
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 4e-101 50
ECs4568 NP_312595.1 EscN Virulence LEE Protein 6e-101 50
escN YP_003236088.1 translocator EscN Virulence LEE Protein 7e-101 50
escN AAC31513.1 L0034 Virulence LEE Protein 4e-101 50
escN NP_290268.1 hypothetical protein Virulence LEE Protein 6e-101 50
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 2e-75 49
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 2e-75 49
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 2e-76 49
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 3e-83 49
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 7e-78 48
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 3e-79 48
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 7e-80 48
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 2e-77 47
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 4e-76 47
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 3e-76 47
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 9e-79 47
invC AAS66861.1 InvC Not tested SSR-2 Protein 1e-70 47
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-71 45
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 4e-71 45
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-71 45
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-71 45
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 9e-69 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 9e-69 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI1 NP_991815.1 type III secretion system ATPase VFG0515 Protein 5e-112 59
fliI1 NP_991815.1 type III secretion system ATPase VFG0192 Protein 5e-99 57
fliI1 NP_991815.1 type III secretion system ATPase VFG0390 Protein 7e-98 56
fliI1 NP_991815.1 type III secretion system ATPase VFG2331 Protein 4e-76 53
fliI1 NP_991815.1 type III secretion system ATPase VFG0048 Protein 1e-96 52
fliI1 NP_991815.1 type III secretion system ATPase VFG0730 Protein 2e-101 50
fliI1 NP_991815.1 type III secretion system ATPase VFG0812 Protein 2e-101 50
fliI1 NP_991815.1 type III secretion system ATPase VFG2144 Protein 4e-84 50
fliI1 NP_991815.1 type III secretion system ATPase VFG1254 Protein 6e-84 50
fliI1 NP_991815.1 type III secretion system ATPase VFG2499 Protein 8e-77 50
fliI1 NP_991815.1 type III secretion system ATPase VFG1778 Protein 5e-70 47
fliI1 NP_991815.1 type III secretion system ATPase VFG2459 Protein 9e-75 45
fliI1 NP_991815.1 type III secretion system ATPase VFG0555 Protein 2e-71 45
fliI1 NP_991815.1 type III secretion system ATPase VFG1008 Protein 7e-69 44