Gene Information

Name : clpA3 (YP_2573)
Accession : NP_993890.1
Strain : Yersinia pestis 91001
Genome accession: NC_005810
Putative virulence/resistance : Virulence
Product : Clp ATPase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2848518 - 2851268 bp
Length : 2751 bp
Strand : -
Note : highly similar to Yersinia pestis KIM y1538. Contains Disease resistance protein (Interpro|IPR000767, (GO:0006952)). Contains Chaperonin clpA/B (Interpro|IPR001270). Contains ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687, (GO:0005524)). Contai

DNA sequence :
ATGGTGCATCAAGCATTATTTCATGAACAATTTAAACTACACATGAACGCCGTTAAAAAGACCAGGATAAAAAACGTGGC
TATTACAAGGAAACATCTCTTCGGCAAGCTGGACGCCACTCTTTTCAAAGGTATTGAAAGCGCAACAACGATTTGTAAAT
TACGCGGCAATCCTTACGTAGAGTTAGTTCACTGGTTGAATCAGCTTTGGCATCAGGAAGATAACGACCTTAAGCAGATT
ATTCGGTATTTTGCGGTGGATGTGGATGCCTTTGAGCGTGAACTGGCTCAGGCACTTGCGAAGTTACCTGTTGGGGCAAC
TAGCATTTCAGATTTTTCGTATCATATTGAGTTGGCCACGGAACGGGCTTGGATCTATGCCAGCCTGGAGTGTTTAGATA
CCCGTATCCGCAGCGGACATCTGCTGCTTGCGCTATTAACCACAATGGAACTGCGGAGAGCTTTCTTTGCGATTGCGCCA
AGCATGGAAAAAATTCCATTAGAGCATTTAAGCAAAGATTTGAACTTCATTACGCAGGCATCACCAGAAGCGAATGAAGC
CGCCAGTGATGGCAGCCCGTTGTACGATGGTGCTTTACCTGGCGAAGCCAGTAATGCCATTGGTGCAGCCAAAAGTGGTG
GCGCACTGGCTCAATACACCACAGACCTCACGGCATTAGCACGTGAAGGCAAGATAGATCCGGTATTGGGACGTAATCAC
GAAATCAACACAATGGTTGATATTCTCTTGCGCCGTCGGCAGAACAACCCATTACTTACCGGTGACGCAGGGGTGGGTAA
AACCGCCATTGTTGAAGGGCTAGCATTGGCTATTGCTGCTGGCTCAATGCCACCAGCATTAAGCCAGGTAAGCCTGTTGT
CATTAGATATTGTGGCGCTCTCAGCGGGTGCCAGCATGAAAGGTGAATTTGAAGCGCGCCTGAAGAGTGTCTTGGATGAA
GCGATAGCGGCAGAAAAGCCCGTTATTTTGTTTATCGATGAAGTACACACACTTATTGGCGCGGGTGGCAATGCCGGGAC
CGGCGATGCGGCGAACTTATTGAAACCTGCATTGGCGCGTGGCCAGTTACGTACCATTGGTGCGACAACGTGGAGCGAGT
TCAAGCGTCACATTGAGAAGGATCCGGCACTCACCCGTCGTTTCCAAGTACTTCAAGTTGATGAGCCCGATGAGAACACG
GCGATCTCCATGTTACGGGGCCTGATACCTGCGCTAGAAAAGCACCACGGCGTGTGGATTATGGACGAAGCTTTACAGGC
GGCAGTACGGTTGTCTCATCGTTATATCCCTGCGCGTCAGTTGCCGGATAAAGCGATAAGTCTGCTTGATACGGCTTGTG
CACGGATCGCTGTCGCGCAGTTTTCACAACCAATAGAGCTACAGCACTTAACCTTCCAGAGTGAGACGGCGCAAACTGAG
CTGGTTTCCTTAGAGAAAGCGCGGCACTTTGGTAAAGCGCAGGATGCGCGTACTGAGCAGTTGAAAACATCCATTGCTGA
ACATGGCGAGGCTGCGGATAAGCTTGATCAGCGTTGGCAGGCAGAACGCGAATTGGTATCAGCGATTACGACCATAAGAA
CCGCACTGTATGACTTGGTTTCTCAGCCAGAGCCTGATGAGGAAAAACGTCGGGCTTATCAAGCGCAATTAGTTCAGTTG
GAAGCGCAGCTTTCTCAGGTTCGCACTTCACTGCCGTTAGTGCAGACAGAAGTCAACGCTGAAGTGATTGCCAGTATCGT
TGCGGATTGGACCGGCATTCCGGTTGGGCAAATGCTCAAAGACGATATTCGGGCGGTAATGGAGTTGCCACAGCGCCTTG
AAGCACGTGTTATTGGTCAGCCCCATGCATTGATGCAACTGGGTGAAAATATTATGACCGCACGCGCTGGCCTGTCAGAC
CCAAGGAAACCATTGGGGGTCTTTATGTTAGTGGGGCCTTCAGGTGTGGGTAAAACAGAGACGGCCTTAGCGATCGCCGA
GAGCATGTATGGTGGTGAACAGAATATGATCACTATCAATATGAGCGAATATCAGGAATCGCATACCGTTTCCTCTTTAA
AAGGTTCTCCACCGGGATATGTTGGATACGGTGAAGGCGGTGTGTTAACGGAAGCTGTGCGCCGTAAGCCATATAGTGTT
GTGTTGTTAGATGAAATCGAAAAAGCGCACTCTGATGTACATGAGTTATTCTTCCAAGTGTTTGATAAAGGCCAAATGGA
AGATGGTGAAGGGCGTTTTATCGATTTTAAAAATACTATCTTGTTGTTAACCAGTAATGTGGGCAGCGAGTTACTGAGTA
ACTTATTAGCTGATCCAGATACTGCACCGGATCAGGATGGAATATTAAGTGCGTTGCAACCTGAATTGCTGAAAGTTTTC
CCCGCAGCATTTTTAGGGCGAGTTACGGTTATTCCTTATCTTCCGTTACAGCAAGATGCATTGCAGCATATTGTACGGTT
GCATTTAGATCGGATTGGCGCTCGTTTATACTCGCAGCATCAATTGACACTGAAATACAGTGATGAAGTGGTTGAAGATG
TTGTTAGCCGCTGTGCGGTCTCAGAGACCGGTGCGCGTATGCTGATCCGTTACATTGAACAAAATATTACGCCAAAAATA
GGTAAATATATTTTAGGTGATAGTGATGTGAAGCCTGAGCAAATTATTTTCGTTCATAAAAATGAAAATGGATTCGTGAT
CGCTTTACAGTGTAAAGATGACGAAAACTAA

Protein sequence :
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYVELVHWLNQLWHQEDNDLKQI
IRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELATERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAP
SMEKIPLEHLSKDLNFITQASPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVALSAGASMKGEFEARLKSVLDE
AIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALARGQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENT
AISMLRGLIPALEKHHGVWIMDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLVSQPEPDEEKRRAYQAQLVQL
EAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLKDDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSD
PRKPLGVFMLVGPSGVGKTETALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPDTAPDQDGILSALQPELLKVF
PAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQHQLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKI
GKYILGDSDVKPEQIIFVHKNENGFVIALQCKDDEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 0.0 58
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 9e-130 46
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 7e-130 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpA3 NP_993890.1 Clp ATPase VFG2076 Protein 0.0 55
clpA3 NP_993890.1 Clp ATPase VFG2084 Protein 3e-138 44