Gene Information

Name : clpA2 (YP_1362)
Accession : NP_992727.1
Strain : Yersinia pestis 91001
Genome accession: NC_005810
Putative virulence/resistance : Virulence
Product : ATPase subunit of ATP-dependent protease
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1492058 - 1494700 bp
Length : 2643 bp
Strand : +
Note : highly similar to Yersinia pestis CO92 YPO1471. Contains Chaperonin clpA/B (Interpro|IPR001270). Contains ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687, (GO:0005524)). Contains AAA ATPase (Interpro|IPR003593, (GO:0000166)). Contains AAA ATPase

DNA sequence :
ATGACAACGCATTCAGCACACTTATTACGTCGGTTAAATCCCTATTGCGCACAGGCACTGGCCGGTGCCGCCACCCTGTG
TCAGACCCGCGCCCATGCTGAGATCACTGTCGAACACTGGTTGTTAAAATTGCTGGAGCAGGGCGAAGGCGATATTACAG
TCATTGCCCGGCGTTATGAGTGGGACATGGACAGCCTGTGGCAGGGATTACTGTCCCATCTGGACACCTTGCCGCGCACG
GTACAGGGCAAACCTCAGTTGTCCGCCGCGTTACAGCAACTGATCAAAAACGCCTGGCTGGATGCCTCGTTGCAGGAAAA
TGCTGATGCGGTGCGCTCGGTTCATCTAATGGCAGCGCTGATTGCCACGCCGTCATTATTGGTCGCCGAGGCCGCCTGGC
CGTTGCTCAGCCTGAGCACCACTCAGCTACAGCGCCTGTTACCGCTGCTGGACAACCAGTCCGACGAACGCCCTGAGGTG
CAGCAGGCTGCGGCACTGGCCGACAGCCCGGTCAATCTGACCGATGAGGCCGCGACGGTTACCTCCGCCAGTGGTCAGCC
GCAACTGAATGACGCGCTGCAAGCGGCGCTGGATAAATTCACCCTCGACGTCACCGCCAAAGCCCGTGCCAACCAGATTG
ACCCGATTTTTGGCCGCGACAGCGAAATCCGCCAGATGATCGACATCCTGTCGCGCCGCCGTAAAAACAACCCGATTCTG
GTGGGTGAACCGGGTGTGGGGAAAACCGCGCTGGTTGAAGGGCTGGCACTGCGGATTGCCGACGGCAACGTACCGGACAG
CCTGAAAACCGTCAGTGTGCGCACACTGGATTTGGGTCTGTTACAGGCCGGGGCTGGGGTGAAAGGCGAATTCGAACAGC
GCCTGAAAAATGTTATCGAGGCGGTGCAACAATCCCCCAGCCCGGTGCTGCTGTTTATCGACGAAGCCCACACCATTATC
GGGGCCGGTAATCAGGCCGGTGGTGCCGATGCGGCCAACCTGCTGAAACCTGCACTGGCGCGTGGCGAACTGCGCACCAT
CGCCGCCACCACCTGGTCCGAATACAAACAGTATTTTGAACGCGATGCCGCACTGGAGCGCCGCTTCCAGATGGTCAAAG
TGGACGAGCCGGATGATGACACCGCCTGCCTGATGCTGCGTGGCCTGAAAGAACGTTACGCCACCCATCACGGCGTGCAT
ATTCTGGACGCCGCTATCACCGCAGCGGTTACCCTGTCGCGCCGCTTTCTGACCGGTCGCCAACTGCCGGACAAAGCGGT
GGATCTTCTCGACACCGCAGGTGCGCGCGTGCGCATGAGCATCGACACCTTGCCGACTGCGTTGATGGAGATTAACGCCG
AACTGGCCGCACTGGCGATGGAGCAACAGGCCATCGAACAGGACTTGCTCCTGCTGCCGAATGTCAGTTCAACGCGCTTA
CCTGAGATTGAGCAACGCCGCGCCGCGCTGGCGGTTGGGCAGCACACACTCGAACAGCAATATAAAGAAGAGAAGCGGTT
GACCACCCTGATTATTGAGGCGCGTCAGGACATCGCCAACGCAGCACATCTGGTCGCGTTGCAGGAGGAACTCGTTCAGA
TTCAGGGCAATGCGCCGCTGTTGTCGCTGGACGTTGATGTGCGCACTGTTGCGGCTGTGATCGCCGACTGGACCGGTGTG
CCGCTGGGCAGTTTACTCAAAGACGAACAAACCAACTTGCTGTCACTGGAAAATCGTCTGGGTGAGCGAGTGATTGGGCA
GGATGCGGCATTAGGTGCGCTGGCGCAACGGCTGCGGGCCGCCAAAACCGGCCTGACATCAGAGAATGGCCCGCTGGGGG
TGTTCCTGCTGGTCGGGCCGAGTGGGATCGGCAAAACCGAAACCGCGTTGGCACTGGCCGACAGCCTGTTCGGCGGGGAA
AAATCGCTGATCACCATCAACTTATCGGAGTATCAGGAAGCGCACACCGTCTCCCAGTTGAAAGGGTCGCCCCCGGGTTA
TGTCGGTTACGGACAGGGCGGCGTATTAACCGAAGCGGTACGTAAACGGCCTTACAGCGTGGTGCTGCTGGATGAAGTGG
AAAAAGCCCATCGTGATGTGCTGAACCTGTTCTATCAGGTGTTTGACCGGGGGTTCATGCGCGACGGTGAAGGGCGCGAA
ATTGATTTCCGCAACACGGTCATTGTGATGACCGCCAATCTGGGCAGTGATCATCTGATGCAGTTGCTGGATGAGCAACC
GGACGCGCCGGACAGCACCCTGCATGAACTGCTGCGGCCGATCCTACGCGACCACTTCCAGCCCGCGCTGCTGGCCCGCT
TCCAGACCTTGATTTACCGCCCGCTTCAGGTGGATGCGCTCAAACGCATTGTGGCGATAAAACTGAATCAGGTGGCGCAA
CGCCTGCACTGTCACTACGGCCTGAGCTGCCAGATTGAAGACAGCCTGACCGACACACTGGTCGCCGCCTGCCTGCTGCC
GGACACCGGCGCACGCAACATCGACAGCCTGCTCAATCAGCAGATTTTACCGGTATTGAGCCAGCAGCTGTTAAGCCGCA
TGAGCGAGCAACAGCGCACCACCTCGCTGACGCTGGGCTGGCATGAAGAAGATGGCATCACGCTGACATTTGAGGGCGAA
TAA

Protein sequence :
MTTHSAHLLRRLNPYCAQALAGAATLCQTRAHAEITVEHWLLKLLEQGEGDITVIARRYEWDMDSLWQGLLSHLDTLPRT
VQGKPQLSAALQQLIKNAWLDASLQENADAVRSVHLMAALIATPSLLVAEAAWPLLSLSTTQLQRLLPLLDNQSDERPEV
QQAAALADSPVNLTDEAATVTSASGQPQLNDALQAALDKFTLDVTAKARANQIDPIFGRDSEIRQMIDILSRRRKNNPIL
VGEPGVGKTALVEGLALRIADGNVPDSLKTVSVRTLDLGLLQAGAGVKGEFEQRLKNVIEAVQQSPSPVLLFIDEAHTII
GAGNQAGGADAANLLKPALARGELRTIAATTWSEYKQYFERDAALERRFQMVKVDEPDDDTACLMLRGLKERYATHHGVH
ILDAAITAAVTLSRRFLTGRQLPDKAVDLLDTAGARVRMSIDTLPTALMEINAELAALAMEQQAIEQDLLLLPNVSSTRL
PEIEQRRAALAVGQHTLEQQYKEEKRLTTLIIEARQDIANAAHLVALQEELVQIQGNAPLLSLDVDVRTVAAVIADWTGV
PLGSLLKDEQTNLLSLENRLGERVIGQDAALGALAQRLRAAKTGLTSENGPLGVFLLVGPSGIGKTETALALADSLFGGE
KSLITINLSEYQEAHTVSQLKGSPPGYVGYGQGGVLTEAVRKRPYSVVLLDEVEKAHRDVLNLFYQVFDRGFMRDGEGRE
IDFRNTVIVMTANLGSDHLMQLLDEQPDAPDSTLHELLRPILRDHFQPALLARFQTLIYRPLQVDALKRIVAIKLNQVAQ
RLHCHYGLSCQIEDSLTDTLVAACLLPDTGARNIDSLLNQQILPVLSQQLLSRMSEQQRTTSLTLGWHEEDGITLTFEGE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 1e-130 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpA2 NP_992727.1 ATPase subunit of ATP-dependent protease VFG2076 Protein 7e-147 44
clpA2 NP_992727.1 ATPase subunit of ATP-dependent protease VFG2084 Protein 4e-130 43