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Name : ureC (plu2173) Accession : NP_929433.1 Strain : Photorhabdus luminescens TTO1 Genome accession: NC_005126 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 2558849 - 2560564 bp Length : 1716 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC DNA sequence : ATGCCAACCATTTCCCGGCAGGAATATGTAGGTCTTTTTGGCCCGACGACTGGCGATAAGATCCGCTTGGGTGATACCAA TCTATTTATTGAAATTGAAAAAGATCTGCGCGGTTACGGTGATGAATCGGTCTATGGCGGGGGCAAATCGCTGCGTGATG GTATGGGTGCGGATAACCGAATGACCAGCGAAAACATCTTGGATTTGGTGATTACCAGCGTCACTATTTTGGATGCCCGG CAAGGTGTTATTAAAGCGGATGTCGGCATAAAAGGGGGACGCATTGTCGGGATAGGTAAAAGTGGTAATCCTAACATGAT GAATGGTGTTACCCCCGGTATGGTAGTTGGTGTTAGTACTGATGCGATATCCGGTGAACATCTCATCCTCACGGCTGCTG GCATTGATACCCATATTCATTTTATTTCTCCTCAACAGGTTGAACATGCTTTATCCAATGGTGTGACGACTTTCTTTGGC GGTGGTGTTGGTCCCACTGATGGCACTAACGGCACTACTGTTACCGCTGGTCCGTGGCATATCCACCGCATGCTGCGTGC TTTTGAGAGTTTACCGGTTAACGTAGGTATTTTGGGAAAAGGCCATGCTGCGGTGGCTATGCCGCTGGTTGAGCAGATCA AAGCGGGTGTTGCCGGGTTGAAAGTGCATGAGGACTGGGGCGCAACTAACTCCGCATTGCGTAATGCCTTACGCGTAGCG GATGAAATGGATATCCAAGTCGCGGTGCACACCGATAGCTTGAATGAAGGTGGTTATGTTGAGGATACCATTGATGCTTT TGAAGGTCGCACCATTCATACTTTCCACACCGAAGGTGCCGGTGGCGGGCATGCACCGGATATCATTAAAGTTGCCAGCC AGATGAATGTGTTGCCTAGTTCGACTAATCCTACCCTGCCTTACGGTATCAATAGCCAGGCAGAATTGTTTGATATGATT ATGGTTTGCCATAACCTTAATCCCAAAGTGCCGGCTGATGTTGCATTTTCGGAAAGCCGTGTACGTCCAGAGACCATTGC GGCGGAGAATGTTTTGCACGATATGGGCGTACTGTCGATGTTTTCCAGTGATTCTCAGGCTATGGGGCGGGTGGGAGAAA ACTGGTTGCGTGTGATGCAAACTGCTCATGCCATGAAAGCGGCGCGTGGCAAGTTGCCGGAGGATGCAGCACATAACGAT AACTTCCGTGTATTACGTTACGTCGCCAAAATTACGATTAACCCGGCTATTGCTCAGGGAATAAGCCATGTGCTCGGTTC AGTTGAAGTGGGAAAAATGGCGGATCTTGTGCTGTGGGAGCCACGTTTTTTTGGCGTAAAACCTAAGTTGGTCATCAAAG GCGGGATGATTAATTGGGCGGTGATGGGGGACCCAAATGCTTCACTGCCGACACCACAACCGACATTTTATCGTCCGATG TTTGGCGCATTGGGCAAAACTCTTCAGGAAACCTGTGTCACTTTTGTATCCCAAGCAGCAATGGAACTGGGGGTAAAAGA GAGCCTTGGTTTGGAGCGCCAAGTTATGGCAGTGCACAACTGCCGGGCTATCTCTAAGAAAGATATGGTGCGTAATGCTG AAACGCCCACGATTGAAGTGGATGCAGAAACCTTTGCCGTCAGGGTGAATGGTGAATATGCCACAGTAAAACCGGTCAGG ACAGTCGCGCTCAATCAGCGCTATTTCTTTAGTTAA Protein sequence : MPTISRQEYVGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGDESVYGGGKSLRDGMGADNRMTSENILDLVITSVTILDAR QGVIKADVGIKGGRIVGIGKSGNPNMMNGVTPGMVVGVSTDAISGEHLILTAAGIDTHIHFISPQQVEHALSNGVTTFFG GGVGPTDGTNGTTVTAGPWHIHRMLRAFESLPVNVGILGKGHAAVAMPLVEQIKAGVAGLKVHEDWGATNSALRNALRVA DEMDIQVAVHTDSLNEGGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIKVASQMNVLPSSTNPTLPYGINSQAELFDMI MVCHNLNPKVPADVAFSESRVRPETIAAENVLHDMGVLSMFSSDSQAMGRVGENWLRVMQTAHAMKAARGKLPEDAAHND NFRVLRYVAKITINPAIAQGISHVLGSVEVGKMADLVLWEPRFFGVKPKLVIKGGMINWAVMGDPNASLPTPQPTFYRPM FGALGKTLQETCVTFVSQAAMELGVKESLGLERQVMAVHNCRAISKKDMVRNAETPTIEVDAETFAVRVNGEYATVKPVR TVALNQRYFFS |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 7e-146 | 59 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 7e-146 | 59 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-138 | 57 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 5e-138 | 57 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-138 | 57 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-138 | 57 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | NP_929433.1 | urease subunit alpha | VFG0270 | Protein | 6e-143 | 59 |
