Gene Information

Name : cvrA (WS1742)
Accession : NP_907866.1
Strain : Wolinella succinogenes DSM 1740
Genome accession: NC_005090
Putative virulence/resistance : Unknown
Product : potassium/proton antiporter
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG3263
EC number : -
Position : 1640876 - 1642342 bp
Length : 1467 bp
Strand : +
Note : the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli

DNA sequence :
ATGGACAATCTTGAACTCTATCTCCTCATTAGCGCCCTCTTAATGCTTCTTAGCGTGGTTTCTAGCAAGCTTTCAGACAA
GTTTGGAATCCCTGCGCTTTTTATCTTTTTAGGGCTTGGGATGCTAGCGGGATCCGATGGGATTCTTGGAATCTACTTTG
ACAACGCCAAACTCGCCCAAAGCGTTGGCACCCTCGCGCTCATCTTCATCCTTTTTGGCGGAGGGCTTGACACCTCATGG
AAAGCGATCAAGCCCGTGCTAGGCGCAGGACTCGCGCTAGCCACTTTTGGGGTGATTTTCACCGCACTCTTTGTGGCGCT
CAGCGTGCGCTATTTGCTTGATTTCACATGGCAAGAATCGCTCCTTCTAGGCGCCATCATCTCTTCAACCGATGCCGCGG
CTGTTTTTGCGATATTGCGCGCCCAAGGAATCTCACTCAAAAAACGCCTCGCCCCTCTACTAGAGCTTGAATCAGGCAGC
AACGACCCCATGGCGATCTTCCTCACAGTGGCGATTTTGCAGATGATTCTCCTCCCTGAGAGCTCCTCACTAGGGGAGTG
GATCGGGAAATTTTTCCTGCAGTTTTTAGTCGGGGGAATCATGGGCTATCTTTTTGGGATTCTCCTCCCTCCTATCTTCA
ATCGCATTCATCTGGGGCACTATGGACTCTATCCTGTCTTTAGCATCGCATGGGTCTTGCTCCTTTTTAGTGCAAGCTCT
TTTTTGGGAGGGAATGGATTCTTAGCCGTCTATATCGCAGGCATCGCCTCTAATGCCCGCGAATTTGTCCACAAAAAGAA
TCTCATCGGATTCCATGATGGGCTCGCATGGATCATGCAGATCGCCGTTTTTCTCACGCTCGGCCTCTTGGTCTTCCCTT
CTGATCTCCCCGCCATCGCCCCTGCAGCCATTGGTATCTCTTTGTGGCTTATCTTTGTAGCGCGTCCTTTGGGGGTTTTT
CTCACGCTCACTTTCAGCTCTTTAAGCCTCCAAGAGAAGAGTTTCATCTCTTGGGTGGGTCTTAGGGGCGCAGTTCCGAT
TATCCTAGCGACCTATCCGTTTTTAGCAGGACTGGAAAGCTCTTCGCTCATCTTTAACACCATCTTTTTTATCGTGCTCA
CTTCCATACTCATCCAAGGCACCACCCTCCCAAGGGTCGCCAAATGGCTCAAGGTCGAAGAATCCAAAGAGTCCAAAGTG
CCCGAACCAAGCATCATCGCCTCGCCTCTTTTGCATCACACGCTCAAACAGTTCTATATCACTAAAAACTCTAGCGTCAT
TGGCAAAAGTATTGCCGAGCTGGAGCTTCCTAGTGAATTCTTGATTCTTCTCATCAAGCGAGAAAAAGAGCAGATCAAGC
CCACAGGCTCAACCCTCTTTGAGGAGGGCGATATGCTTCTCATCCAGTGTGAAGATCCTGCACTCTTTCGCCAGATCGTT
CGCTCTTTCGCGCCTTTGGAATCTTAG

Protein sequence :
MDNLELYLLISALLMLLSVVSSKLSDKFGIPALFIFLGLGMLAGSDGILGIYFDNAKLAQSVGTLALIFILFGGGLDTSW
KAIKPVLGAGLALATFGVIFTALFVALSVRYLLDFTWQESLLLGAIISSTDAAAVFAILRAQGISLKKRLAPLLELESGS
NDPMAIFLTVAILQMILLPESSSLGEWIGKFFLQFLVGGIMGYLFGILLPPIFNRIHLGHYGLYPVFSIAWVLLLFSASS
FLGGNGFLAVYIAGIASNAREFVHKKNLIGFHDGLAWIMQIAVFLTLGLLVFPSDLPAIAPAAIGISLWLIFVARPLGVF
LTLTFSSLSLQEKSFISWVGLRGAVPIILATYPFLAGLESSSLIFNTIFFIVLTSILIQGTTLPRVAKWLKVEESKESKV
PEPSIIASPLLHHTLKQFYITKNSSVIGKSIAELELPSEFLILLIKREKEQIKPTGSTLFEEGDMLLIQCEDPALFRQIV
RSFAPLES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AAB61290.1 unknown Not tested PAI I CFT073 Protein 1e-42 44
f536 AAC61706.1 F536 Not tested PAI I CFT073 Protein 1e-42 44