Gene Information

Name : guaA (WS1603)
Accession : NP_907739.1
Strain : Wolinella succinogenes DSM 1740
Genome accession: NC_005090
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1515484 - 1517049 bp
Length : 1566 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGTATTCAACTACACGATAAGGTTTCGCTACTGATTTTGGACTTTGGGAGCCAATACACTCAGCTCATCGCAAGGCG
ACTAAGGGAGTATGGAATCTACTGCGAAATCGTCCCCTACCACGAGAAGCTAGAGGCGATTAAAGCACGCGAACCCAAGG
GAATCATCCTCAGCGGGGGACCAGCGAGCGTCTATGAAGAGGATGCTTTCTTGATTGATAAGGCGGTTTTTGAGCTTGGA
ATTCCTGTTCTTGGAATCTGCTATGGAATGCAGCTCATGACCCACTACTTTGGCGGTGTGGTGGCCAAGGCGGAGCATCA
TGAATATGGCAAGGCTGAGGTGATTTTTGATGCCCTTGAGGGGAGTGAGTCGAAGCTTTTTGAAGGGTGCCATAGCGGCA
AAGTGGTCTGGATGAGCCATGGCGACAAGGTGGAGAAATTGCCTGAAGGATTCACAAGAATCGCCCACTCCACGAACTCT
CCCTTTGCGGCGATTGCCCACCAAGAGAAGCCTTTTTATGCGGTGCAGTTTCACCCCGAGGTCGTCCACTCTGAAGAGGG
AGCGCTCTATCTTAAAAATTTCGCTCTAGGAATCTGTGGCTGCGAAAATGATTGGAATATGCATAACTTCGCCGAGGAGC
AGATCAAAAAGATTCAAGAGCGCGTCAAGTCGGGCAAAGTGCTCTGCGCCGTCTCGGGTGGGGTTGATTCAAGCGTAGTG
GCTGCGCTTTTATATCGCGCGATTGGGGAGAAGCTGATTCCTGTTTTTGTCGATCATGGGCTTTTGAGGGCAGGTGAGCG
CGAGGCGGTCGAGAAGATGTTCAAAGAGAATCTCCATGTTCCTCTGATCACGGTGGATGCAAGCGAGATTTTCCTTGGCA
AGCTCAAAGGGGTGAGCGATCCAGAGACGAAGCGTAAAATCATCGGCGAGACCTTCATTGAGGTGTTTGATGTGGAGGCG
AAAAAGCATGATGGCATCCAATATCTTGCTCAAGGCACGCTCTATCCTGATGTGATCGAATCGGTCTCCGTCAAGGGCCC
CAGCAAGACGATTAAGTCCCACCACAATGTTGGCGGACTGCCTGATTGGATGACCTTTGAGCTGATTGAGCCCCTAAGAG
AGCTCTTCAAGGATGAGGTGAGGGCGCTTGGAGCGGAGCTTGGGATGCCAAGAGAGATGCTCATGCGCCATCCTTTCCCC
GGACCGGGGTTAGCTATCCGTATCATGGGCGAGGTCAACTTTGAAGATTTGGAGCTTTTGAGAAAAGCAGATGTGATCAT
GCTTGATGAGCTCAAAAAGAGTGGCTTTTATGACAAAACTTGGCAGGCGTTCACCGTGCTTCTGAATGTGCGAAGCGTAG
GCGTGATGGGCGATAACCGCACCTATGACAACACGGTCTGCGTTCGCGTGGTCGAGGCGATTGATGGGATGACTGCGACT
TTTGCGCATCTGCCCCATGAGCTTTTAGAGAGAATGTCCACACGAATCATCAACGAAGTGGATGGAATCAACCGCGTGGT
CTATGATATCAGCTCCAAGCCGCCTGCCACGATTGAGTGGGAGTGA

Protein sequence :
MSIQLHDKVSLLILDFGSQYTQLIARRLREYGIYCEIVPYHEKLEAIKAREPKGIILSGGPASVYEEDAFLIDKAVFELG
IPVLGICYGMQLMTHYFGGVVAKAEHHEYGKAEVIFDALEGSESKLFEGCHSGKVVWMSHGDKVEKLPEGFTRIAHSTNS
PFAAIAHQEKPFYAVQFHPEVVHSEEGALYLKNFALGICGCENDWNMHNFAEEQIKKIQERVKSGKVLCAVSGGVDSSVV
AALLYRAIGEKLIPVFVDHGLLRAGEREAVEKMFKENLHVPLITVDASEIFLGKLKGVSDPETKRKIIGETFIEVFDVEA
KKHDGIQYLAQGTLYPDVIESVSVKGPSKTIKSHHNVGGLPDWMTFELIEPLRELFKDEVRALGAELGMPREMLMRHPFP
GPGLAIRIMGEVNFEDLELLRKADVIMLDELKKSGFYDKTWQAFTVLLNVRSVGVMGDNRTYDNTVCVRVVEAIDGMTAT
FAHLPHELLERMSTRIINEVDGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-136 56
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-136 56
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-136 56
guaA NP_938969.1 GMP synthase Not tested Not named Protein 6e-119 52