Gene Information

Name : invC (CV_2628)
Accession : NP_902298.1
Strain : Chromobacterium violaceum ATCC 12472
Genome accession: NC_005085
Putative virulence/resistance : Virulence
Product : ATP synthase SpaL
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 2834493 - 2835782 bp
Length : 1290 bp
Strand : -
Note : Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase

DNA sequence :
ATGAAGCCGCCGCGGCTGCTGCGCAGGCTGGCCAACCCCCAGCGCCTGTCCGGCCCCATCCTGGAGGCGGTGCTGCCCGG
GGTGGCGGTAGGCGAGCTGTGCGAGATCCGCCGCAACTGGCAGGAGCGCGAGGTGGTGGCGCGGGCGCAGGTGGTCGGCT
TCCAGCATGAGCGGGCGGTGCTGAGCCTGATCGGCAACGCCAGGGGCTTGTCGCGAGAGGCGGTGCTGCAGCCGACCGGC
CGGGCTTTGTCCGCCTGGGTGGGCGAGGAGGCGCTGGGCGCGGTGCTGGACCCGACCGGCCGCGTCGTCGAACGCTTTTC
TCCGGCCGCGGCCGGCGGCGGCGAGGCGCGCGACATCGACAGCGATCCGCCGCCTTATTCCCGCCGGGTGGGCGTGCGCG
AACCGCTGGCCACCGGCGTACGGGCGATAGACGGCCTGCTGACCTGCGGCGTCGGCCAGCGAGTGGGCATCTTCGCCTCG
GCCGGCTGCGGCAAGACCATGCTGATGCACATGCTGATCGAACAGGCGGACGCCGATGTGTTCGTGATCGGCCTGATCGG
CGAACGCGGACGCGAAGTCACGGAATTCGCCGAGGCGCTGCGCGGCTCGGACAAGCGCGACCGCTGCGTGCTGGTATTCG
CCACCTCGGATTTCCCGTCGGTGGACCGCTGCAACGCGGCGCTGCTGGCCACCACGGTGGCCGAGTATTTCCGCGACCAG
GGCAAGAAGGTGGTGCTGTTCGTCGATTCGATGACCCGCTACGCCCGCGCGCTGCGCGACGTGGCGCTGGCCGCCGGCGA
GCCGCCGGCCCGGCGCGGCTATCCGGCCTCGGTGTTCGACAGCCTGCCGCGCCTGCTGGAGCGGCCGGGCGCCACCGGCG
CAGGCAGCATCACCGCTTTTTACACGGTGCTGCTGGAGAGCGACGACGAGCCGGACCCGATGGCGGACGAGATCCGCTCG
ATCCTGGACGGCCACATCTATCTGAGCCGCAAGCTGGCCGGCCAGGGCCATTACCCGGCGATAGACGTGCTCAAGAGCGC
GAGCCGCGTGGCCGGCCAAGTGACGGACACCGGCCAGCAGCAGGCGGCCGCCGCCGTGCGCGGCCTGCTGGCGCGGCTGG
AGGAGCTGCAGGTGTTCATCGACCTGGGCGAATACCGGCCAGGGGAGAACGCGGACAACGACAGGGCGATGAGCCTGCGC
GATCCGCTGCGGCGGTGGCTGCGCCAGCGCATGGACGAGCGAGCCGCTTACCGGGACACGCTGGAGAGCATGGATGGCTT
CCGCGCTTAA

Protein sequence :
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAVLSLIGNARGLSREAVLQPTG
RALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDIDSDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFAS
AGCGKTMLMHMLIEQADADVFVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAFYTVLLESDDEPDPMADEIRS
ILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQQAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLR
DPLRRWLRQRMDERAAYRDTLESMDGFRA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-162 77
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-162 77
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 4e-162 77
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 4e-162 77
invC AAS66861.1 InvC Not tested SSR-2 Protein 7e-141 68
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 6e-133 64
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-110 57
escN CAI43874.1 EscN protein Virulence LEE Protein 2e-70 50
escN YP_003223475.1 translocator EscN Virulence LEE Protein 2e-70 50
lscN AAO18044.1 LscN Virulence TTSS locus Protein 4e-87 49
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 7e-74 49
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 2e-79 48
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 2e-79 48
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 48
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 4e-80 48
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 48
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-78 48
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 8e-79 48
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 2e-70 48
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-70 48
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-70 48
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 1e-70 48
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-70 48
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-79 47
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-79 47
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 2e-72 47
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 2e-65 46
escN NP_290268.1 hypothetical protein Virulence LEE Protein 1e-70 46
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 1e-70 46
ECs4568 NP_312595.1 EscN Virulence LEE Protein 1e-70 46
escN AAC31513.1 L0034 Virulence LEE Protein 1e-70 46
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 3e-65 46
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 6e-71 46
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 1e-70 46
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 6e-75 46
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 1e-70 46
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 2e-61 45
escN AAC38383.1 EscN Virulence LEE Protein 1e-70 45
escN CAC81862.1 EscN protein Virulence LEE II Protein 8e-71 45
escN AAK26715.1 EscN Virulence LEE Protein 2e-70 45
escN AAL57542.1 EscN Virulence LEE Protein 2e-70 45
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 1e-70 45
escN YP_003236088.1 translocator EscN Virulence LEE Protein 2e-70 45
unnamed AAL06369.1 EscN Virulence LEE Protein 5e-70 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-65 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-65 45
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 7e-63 44
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 7e-63 44
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 8e-72 43
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 8e-72 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
invC NP_902298.1 ATP synthase SpaL VFG0555 Protein 2e-162 77
invC NP_902298.1 ATP synthase SpaL VFG2459 Protein 4e-118 61
invC NP_902298.1 ATP synthase SpaL VFG1008 Protein 5e-122 59
invC NP_902298.1 ATP synthase SpaL VFG1778 Protein 2e-107 59
invC NP_902298.1 ATP synthase SpaL VFG0192 Protein 8e-89 51
invC NP_902298.1 ATP synthase SpaL VFG0390 Protein 5e-87 48
invC NP_902298.1 ATP synthase SpaL VFG0048 Protein 2e-83 48
invC NP_902298.1 ATP synthase SpaL VFG0515 Protein 1e-70 48
invC NP_902298.1 ATP synthase SpaL VFG2144 Protein 6e-75 47
invC NP_902298.1 ATP synthase SpaL VFG0812 Protein 6e-71 46
invC NP_902298.1 ATP synthase SpaL VFG0730 Protein 7e-71 45
invC NP_902298.1 ATP synthase SpaL VFG2499 Protein 1e-64 44
invC NP_902298.1 ATP synthase SpaL VFG1254 Protein 2e-65 43
invC NP_902298.1 ATP synthase SpaL VFG2331 Protein 4e-63 41