|
Name : ureC (PMM0963) Accession : NP_893080.1 Strain : Prochlorococcus marinus CCMP1986 Genome accession: NC_005072 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 921384 - 923093 bp Length : 1710 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGTCCTATAAAATTAATCGAAAAACTTATGCTCAAACATATGGACCTACAAAGGGAGATAGAGTAAGACTTGCAGATAC AGAATTAATAATTGAAGTAGAAAAGGATTTTACAACTTATGGAGATGAAGTTAAATTTGGAGGGGGTAAGGTTATCAGAG ATGGGATGGGCCAGTCTCAAGTAACCAGAGAGGATGGAGCTGTTGATACAGTAATAACAAATGCCTTAATAGTCGATTGG TGGGGAATAGTAAAAGCTGATGTCGGATTGAAAGATGGAAAAATTTATGAAATTGGTAAAGCTGGAAATCCAGATATACA AGATAATATAAATATTATTATTGGCTCTTCTACTGAAGTAATAGCTGGTGAAGGACATATTCTTACTGCAGGATCTATTG ATACACATATACATTTTATTTGTCCTCAACAAATAGAAACTGCATTAGCTTCTGGCGTGACAACTATGTTAGGAGGTGGA ACAGGGCCAGCTACCGGAACAAATGCTACCACCTGCACTCCAGGTGCTTTTCATATATCTCGTATGATTCAATCTGCCGA AGCATTTCCTGTTAATTTAGGTTTTTTTGGGAAGGGAAATTCATCTAATGAGACAAATCTTTTTGAACAAGTAAATGCTG GGGCCTGCGGTTTAAAATTACATGAAGACTGGGGTACAACCCCATCAACGATAAATTCATGTCTTAATGTTGCAGATACT CTAGACGTTCAAGTATGTATTCATACTGATACTTTGAATGAAGCAGGGTTTGTTGAAGACACTATAGCTGCCATTGCAGG TAGAACTATTCATACTTTTCATACCGAAGGAGCAGGGGGTGGCCATGCTCCAGATATTATTAAAATTTGTGGAGAAAATA ATGTCTTACCAAGTAGTACTAATCCCACGAGGCCTTACACCAAAAATACTCTTGAAGAACATCTTGACATGTTAATGGTT TGTCATCATTTAGATTCAAAAATTCCAGAAGATATTGCATTTGCAGAGTCAAGAATTAGGAGGGAGACAATAGCTGCGGA GGATATTTTGCATGATATTGGAGCTTTTTCAATTATTGCAAGTGATTCACAAGCTATGGGACGAGTTGGAGAAGTAATAA CAAGAACTTTTCAAACCGCGCATAAAATGAAAGTGCAAAGAGGTCCTTTACCTGAAGATTCTGATAGAAATGATAACTAT AGAGTTAAAAGATATATCTCTAAAGTTACTATTAATCCAGCTATTGCTCATGGAATTAATAGGTTTGTTGGTTCTATAGA AAAGGGTAAAATAGCAGATTTGGTTTTGTGGAAACCTTCATTTTTTGGTGTTAAGCCAGAACTAGTTGTCAAAGGAGGTT CTATAGTTTGGTCTCAGATGGGTGATGCAAATGCTTCAATTCCAACGCCAGGACCTGTTCATGGTAGACCTATGTTTGCG AATTATGGACAATCACTTTTAAAAAGTTCGTTTACTTTTTTGAGTAAAAATGCAATCGAGCTTGATATTCCTAACAAACT TTCTTTACAAAAAAATTGTTTGGCTGTAGAAAACACAAGATCAATTAATAAATTAGATCTAAAATTGAATAATAAATTAC CAAATATCACAGTTGATCCACAAACTTATGAAGTATTCGCTGATGGAGTATTACTTTCTTGTGAACCTCTTGAAGAAGTA CCGATGGCTCAAAAATATTTTTTACTTTAA Protein sequence : MSYKINRKTYAQTYGPTKGDRVRLADTELIIEVEKDFTTYGDEVKFGGGKVIRDGMGQSQVTREDGAVDTVITNALIVDW WGIVKADVGLKDGKIYEIGKAGNPDIQDNINIIIGSSTEVIAGEGHILTAGSIDTHIHFICPQQIETALASGVTTMLGGG TGPATGTNATTCTPGAFHISRMIQSAEAFPVNLGFFGKGNSSNETNLFEQVNAGACGLKLHEDWGTTPSTINSCLNVADT LDVQVCIHTDTLNEAGFVEDTIAAIAGRTIHTFHTEGAGGGHAPDIIKICGENNVLPSSTNPTRPYTKNTLEEHLDMLMV CHHLDSKIPEDIAFAESRIRRETIAAEDILHDIGAFSIIASDSQAMGRVGEVITRTFQTAHKMKVQRGPLPEDSDRNDNY RVKRYISKVTINPAIAHGINRFVGSIEKGKIADLVLWKPSFFGVKPELVVKGGSIVWSQMGDANASIPTPGPVHGRPMFA NYGQSLLKSSFTFLSKNAIELDIPNKLSLQKNCLAVENTRSINKLDLKLNNKLPNITVDPQTYEVFADGVLLSCEPLEEV PMAQKYFLL |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 5e-157 | 66 |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 5e-157 | 66 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-145 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-147 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-147 | 62 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-147 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | NP_893080.1 | urease subunit alpha | VFG0270 | Protein | 1e-141 | 63 |
